{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:50:21Z","timestamp":1786373421986,"version":"build-2736575974"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"name":"Mid-America Transplant\/Jane A. Beckman Endowed Chair in Transplantation"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1K23HL151816-01A1"],"award-info":[{"award-number":["1K23HL151816-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    Living kidney donation and living liver donation significantly increases organ supply to make lifesaving transplants possible, offering survival benefits to the recipients and cost savings to society. Of all living donors, 40% are women of childbearing age. However, limited data exist regarding the effect of donation on future pregnancies and of pregnancy-related complications on postdonation outcomes. In February 2023, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference on reproductive health, contraception, and pregnancy after transplantation and living donation. Experts in the field presented the available data. Smaller breakout sessions were created to discuss findings, identify knowledge gaps, and develop recommendations. We present the conference findings related to living donation. The evidence reviewed shows that gestational hypertension and gestational diabetes mellitus before kidney donation have been associated with an increased risk of developing postdonation hypertension and diabetes mellitus, respectively, without increasing the risk of developing an eGFR &lt;45 ml\/min after donation. The risk of preeclampsia in living kidney donors increases to 4%\u201310%, and low-dose aspirin may help reduce that risk. Little is known about the financial burden for living donors who become pregnant, their risk of\n                    <jats:italic toggle=\"yes\">postpartum<\/jats:italic>\n                    depression, or the optimal time between donation and conception. The data on living liver donors are even scarcer. The creation of a registry of donor candidates may help answer many of these questions and, in turn, educate prospective donors so that they can make an informed choice.\n                  <\/jats:p>","DOI":"10.2215\/cjn.0000000593","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T08:00:43Z","timestamp":1729065643000},"page":"1659-1670","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Living Donation and Pregnancy-Related Complications"],"prefix":"10.2215","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1479-3571","authenticated-orcid":false,"given":"Ana P.","family":"Rossi","sequence":"first","affiliation":[{"name":"Piedmont Transplant Institute, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-4156","authenticated-orcid":false,"given":"Goni","family":"Katz-Greenberg","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-9661","authenticated-orcid":false,"given":"Lisa","family":"Coscia","sequence":"additional","affiliation":[{"name":"Transplant Pregnancy Registry International, Gift of Life, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-3118","authenticated-orcid":false,"given":"Carla W.","family":"Brady","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-8573","authenticated-orcid":false,"given":"Christina","family":"Doligalski","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-4433","authenticated-orcid":false,"given":"Roxanna A.","family":"Irani","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-639X","authenticated-orcid":false,"given":"Arthur","family":"Matas","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-9404","authenticated-orcid":false,"given":"Silvi","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4849","authenticated-orcid":false,"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Transplant Center, Saint Louis University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the AST WHCOP Reproductive Health, Contraception and Pregnancy after Transplantation and Living Donation Controversies Conference 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disorders","volume":"142","author":"Bitar","year":"2023","journal-title":"Obstet Gynecol."},{"issue":"8","key":"B5-20260520","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1056\/NEJMoa0706790","article-title":"Preeclampsia and the risk of end-stage renal disease","volume":"359","author":"Vikse","year":"2008","journal-title":"New Engl J Med."},{"issue":"10","key":"B6-20260520","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1097\/TP.0000000000004146","article-title":"Pre-kidney donation pregnancy complications and long-term outcomes","volume":"106","author":"Helgeson","year":"2022","journal-title":"Transplantation."},{"issue":"9","key":"B7-20260520","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med."},{"key":"B8-20260520","doi-asserted-by":"crossref","first-page":"j3078","DOI":"10.1136\/bmj.j3078","article-title":"Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study","volume":"358","author":"Behrens","year":"2017","journal-title":"BMJ."},{"issue":"10","key":"B9-20260520","doi-asserted-by":"crossref","first-page":"e008318","DOI":"10.1161\/JAHA.117.008318","article-title":"Pregnancy-related risk factors are associated with a significant burden of treated hypertension within 10 Years of delivery: findings from a population-based Norwegian cohort","volume":"7","author":"Egeland","year":"2018","journal-title":"J Am Heart Assoc."},{"issue":"10","key":"B10-20260520","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.2337\/diacare.25.10.1862","article-title":"Gestational diabetes and the incidence of type 2 diabetes: a systematic review","volume":"25","author":"Kim","year":"2002","journal-title":"Diabetes 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2004-2012","volume":"100","author":"Clayton","year":"2016","journal-title":"Transplantation."},{"issue":"4","key":"B65-20260520","doi-asserted-by":"crossref","first-page":"e14908","DOI":"10.1111\/ctr.14908","article-title":"Factors enabling transplant program participation in the scientific registry of transplant recipients (SRTR) living donor collective: a national survey","volume":"37","author":"Lentine","year":"2023","journal-title":"Clin Transplant."},{"issue":"12","key":"B66-20260520","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1111\/j.1600-6143.2011.03816.x","article-title":"Living kidney donor follow-up: state-of-the-art and future directions, conference summary and recommendations","volume":"11","author":"Leichtman","year":"2011","journal-title":"Am J Transplant."},{"issue":"7","key":"B67-20260520","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ajt.2023.03.012","article-title":"Stakeholders' perspectives on transplant metrics: the 2022 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