{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:28:16Z","timestamp":1792578496993,"version":"4.5.0"},"reference-count":166,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Sleep disorders such as insomnia, restless legs syndrome (RLS), and sleep apnea (SA) are common in patients with CKD. These conditions tend to become more prevalent and more severe as kidney function deteriorates and when a patient reaches ESKD. The prevalence of insomnia in the general population ranges from 4% to 29% compared with (\n                    <jats:italic toggle=\"yes\">1<\/jats:italic>\n                    ) 30%\u201367%, (\n                    <jats:italic toggle=\"yes\">2<\/jats:italic>\n                    ) 39%\u201354%, (\n                    <jats:italic toggle=\"yes\">3<\/jats:italic>\n                    ) 41%\u201379%, and (\n                    <jats:italic toggle=\"yes\">4<\/jats:italic>\n                    ) 9%\u201349% in patients with CKD, on hemodialysis, on peritoneal dialysis (PD), or in kidney transplant recipients (KTRs), respectively. RLS occurs in approximately 1%\u201315% of the general population compared with (\n                    <jats:italic toggle=\"yes\">1<\/jats:italic>\n                    ) 5%\u201318%, (\n                    <jats:italic toggle=\"yes\">2<\/jats:italic>\n                    ) 24%\u201333%, (\n                    <jats:italic toggle=\"yes\">3<\/jats:italic>\n                    ) 23%\u201364%, and (\n                    <jats:italic toggle=\"yes\">4<\/jats:italic>\n                    ) 6%\u20138% in patients with CKD, on hemodialysis, on PD, or in KTRs, respectively. Obstructive SA has been reported in (\n                    <jats:italic toggle=\"yes\">1<\/jats:italic>\n                    ) 40%\u201369%, (\n                    <jats:italic toggle=\"yes\">2<\/jats:italic>\n                    ) 25%\u201347%, (\n                    <jats:italic toggle=\"yes\">3<\/jats:italic>\n                    ) 9%\u201352%, and (\n                    <jats:italic toggle=\"yes\">4<\/jats:italic>\n                    ) 25%\u201330% in patients with CKD, on hemodialysis, on PD, or in KTRs, respectively. Fatigue is a complex symptom that has been reported in patients with CKD, ESKD, and in KTRs and can be associated with sleep disorders. Fatigue and sleep disorders have been associated with negative outcomes such as progression of CKD, increased risk of morbidity, mortality, and lower health-related quality of life. In this review, we highlight nonpharmacologic and pharmacologic options for treatment of these sleep disorders. Specifically, the diagnosis and evaluation, epidemiology, risk factors and associations, outcomes (such as CKD progression, morbidity, and mortality), treatment, and post-transplant outcomes for sleep disorders (insomnia, RLS, and SA) and fatigue will be discussed.\n                  <\/jats:p>","DOI":"10.2215\/cjn.0000000728","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:06:47Z","timestamp":1744200407000},"page":"1446-1460","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients"],"prefix":"10.2215","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-4138","authenticated-orcid":false,"given":"Nicolas","family":"Vendeville","sequence":"first","affiliation":[{"name":"Division of Nephrology, Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4781-4699","authenticated-orcid":false,"given":"Istvan","family":"Mucsi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-330X","authenticated-orcid":false,"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, 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