{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:41:03Z","timestamp":1786372863773,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"crossref","award":["312266"],"award-info":[{"award-number":["312266"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007671","name":"Fondation du CHUM","doi-asserted-by":"crossref","award":["Chhay Heang Ly family donation"],"award-info":[{"award-number":["Chhay Heang Ly family donation"]}],"id":[{"id":"10.13039\/100007671","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Point-of-care ultrasound could provide important information to guide fluid administration in AKI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This study demonstrates the feasibility assessing fluid tolerance through lung and venous ultrasound and implementing it in a trial.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Point-of-care ultrasound influenced management in half of patients and lead to higher rate of early diuretic use without negatively affecting kidney function.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Indiscriminate fluid administration in AKI can be harmful, and point-of-care ultrasound (POCUS) could be used to assess for fluid tolerance. The objective of pilot study was to determine the feasibility of a randomized trial comparing a fluid management strategy, including POCUS, with usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a single-center, open-label, pilot randomized controlled trial that recruited noncritically ill patients with AKI for whom fluid administration had begun or was considered. The intervention consisted in the transmission to the nephrology team of a POCUS report on fluid tolerance (assessment of pulmonary B-lines and systemic venous congestion with the venous excess ultrasound score). The control was usual care without POCUS. The primary outcome was feasibility, defined as protocol adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients underwent randomization, 40 were randomized in the POCUS group and 40 in the usual care group, but one withdrew consent before initiating trial procedures. Protocol adherence was achieved in all patients. In the intervention arm, 50% of initial ultrasound reports led to a change in clinical conduct, and the provided information was perceived as useful by clinicians (median 4.5\/5 [interquartile range, 4.0\u20135.0]). The intervention led to a higher use of diuretics during the first day after randomization (40% versus 15%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), but did not result in difference in cumulative fluid balance or diuretic use at 5 days, progression to higher stages of AKI, or composite outcome of death and escalation of care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot trial demonstrate the feasibility of a randomized trial investigating the clinical effect of providing a POCUS fluid tolerance evaluation in AKI. Its effect on clinical management and perceived usefulness support the rationale for future, larger-scale studies.<\/jats:p>\n                    <jats:p>Clinical Trial registry name and registration number: NCT06411080.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.0000001059","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:06:02Z","timestamp":1776787562000},"page":"1126-1134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Pilot Randomized Controlled Trial of Ultrasound Evaluation of Fluid Tolerance for Acute Kidney Injury"],"prefix":"10.2215","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4758-9600","authenticated-orcid":false,"given":"Michel","family":"Gouin","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Denault","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Montreal Heart Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-8703","authenticated-orcid":false,"given":"William","family":"Beaubien-Souligny","sequence":"additional","affiliation":[{"name":"Service of Nephrology, Department of Medicine, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, Quebec, Canada"},{"name":"Centre de recherche du CHUM (CR CHUM), Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"9","key":"B1-20260723","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.2215\/CJN.00710113","article-title":"World incidence of AKI: a 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