{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:52Z","timestamp":1787755852894,"version":"build-2784847793"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","funder":[{"name":"National Institute of Health","award":["2025-E1101-00, 2025-E1101-01"],"award-info":[{"award-number":["2025-E1101-00, 2025-E1101-01"]}]},{"name":"Ministry of Health and Welfare","award":["RS-2024-00403047"],"award-info":[{"award-number":["RS-2024-00403047"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Clonal hematopoiesis of indeterminate potential was more prevalent in patients with CKD than the general population.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Clonal hematopoiesis of indeterminate potential was associated with a higher risk of kidney failure in patients with CKD across both the Korean and European ancestry populations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Variant allele fraction of clonal hematopoiesis of indeterminate potential\u2011associated mutations was higher in patients with CKD than those without CKD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with inflammation. Although CKD shares these pathophysiological features, the prognostic role of CHIP on CKD progression remains unclear, particularly in underrepresented East Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Deep targeted sequencing of CHIP-driving mutations was used to identify the presence of CHIP, defined as variant allele fraction (VAF) \u22652.0%. CHIP prevalence was compared between 175 Korean participants with CKD in the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) cohort and 700 matched general population controls in the Gene-Environmental Interaction and Phenotype (GENIE) cohort. The association between CHIP and kidney failure (KF) risk was evaluated using multivariable Cox regression analysis both in the KNOW-CKD cohort and 232 matched UK Biobank participants with CKD. Furthermore, VAF was compared between CHIP-positive participants in the KNOW-CKD and GENIE cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of CHIP was significantly higher in the KNOW-CKD cohort than in the GENIE cohort (17% versus 11%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). Over a median follow-up of 10.0 years, 66 participants (38%) developed KF in the KNOW-CKD cohort. After multivariable adjustment, CHIP was associated with higher risk of KF (adjusted hazard ratio, 1.90; 95% confidence interval, 1.03 to 3.51). Furthermore, in the UK Biobank, KF occurred in 43 participants (20%) over a median follow-up of 12.9 years and the association of CHIP with higher risk of KF was consistently observed (adjusted hazard ratio, 2.16; 95% confidence interval, 1.15 to 4.03). Furthermore, among CHIP-positive participants, the median VAF of CHIP-associated mutations was significantly higher in participants within the KNOW-CKD cohort compared with healthy controls in the GENIE cohort (7.3% versus 4.4%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CHIP is more prevalent in patients with CKD and serves as an independent risk factor of KF. This association is consistently observed across both an underrepresented East Asian cohort and a European cohort, establishing CHIP as a globally relevant risk factor of CKD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.0000001092","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:02:33Z","timestamp":1781193753000},"page":"1340-1351","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clonal Hematopoiesis of Indeterminate Potential and Kidney Failure in CKD"],"prefix":"10.2215","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-198X","authenticated-orcid":false,"given":"Minsang","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-4589","authenticated-orcid":false,"given":"Hong Yul","family":"An","sequence":"additional","affiliation":[{"name":"NOBO Medicine, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9859-8814","authenticated-orcid":false,"given":"Gangpyo","family":"Ryu","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-7091","authenticated-orcid":false,"given":"Jayoun","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-8374","authenticated-orcid":false,"given":"Yaeni","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-9004","authenticated-orcid":false,"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4101-9993","authenticated-orcid":false,"given":"Yeong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-0477","authenticated-orcid":false,"given":"Siddhartha","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-931X","authenticated-orcid":false,"given":"Youngil","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"NOBO Medicine, Inc., Seoul, Republic of Korea"},{"name":"Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Department of Internal Medicine, Seoul National University College of Medicine, 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