{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:43:47Z","timestamp":1786373027314,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"abstract":"Summary<\/jats:title>\n \n Background and objectives<\/jats:title>\n Renal transplant recipients with pre-existing diabetes (PD) have reduced graft survival and increased risk of mortality and ischemic heart disease compared with nondiabetic transplant recipients. To assess the effect of belatacept in this high-risk group, we evaluated outcomes of the subpopulation with PD from previously published BENEFIT and BENEFIT-EXT trials.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n A\n post hoc<\/jats:italic>\n analysis evaluated pooled data from BENEFIT (living donors or standard criteria donors) and BENEFIT-EXT (extended criteria donors). Patients were randomized to receive cyclosporine or a more intensive (MI) or less intensive (LI) belatacept regimen.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 1209 intent-to-treat patients, 336 had PD. At 12 months, the belatacept LI arm demonstrated a numerically higher rate of patients surviving with a functioning graft (90.4% MI [103 of 114], 92.8% LI [90 of 97], and 80.8% cyclosporine [101 of 125]), and fewer serious adverse events than cyclosporine or MI patients. Three cases of posttransplant lymphoproliferative disorder were reported in LI patients, one involving the central nervous system. Higher rates (% [95% confidence interval]: 22.8% MI [15.1 to 30.5]; 20.6% LI [12.6 to 28.7]; 14.4% cyclosporine (8.2 to 20.6]) and grades of acute rejection were observed with belatacept. Measured GFR (ml\/min per 1.73 m\n 2<\/jats:sup>\n , 59.8 MI; 62.5 LI; 45.4 cyclosporine), and cardiovascular risk profile were better for belatacept\n versus<\/jats:italic>\n cyclosporine.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In\n post hoc<\/jats:italic>\n analysis of patients with PD, patient\/graft survival and renal function at 12 months were numerically higher with belatacept\n versus<\/jats:italic>\n cyclosporine, but not statistically significant. Further study is necessary to confirm the benefits belatacept may provide in these patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.00270111","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T06:32:59Z","timestamp":1316154779000},"page":"2696-2704","source":"Crossref","is-referenced-by-count":28,"title":["Belatacept-versus Cyclosporine-Based Immunosuppression in Renal Transplant Recipients with Pre-existing Diabetes"],"prefix":"10.2215","volume":"6","author":[{"given":"Lionel","family":"Rostaing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans 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