{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:21:42Z","timestamp":1790878902057,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Neuromuscular complications are almost universal in CKD by the time that a patient commences dialysis. Recent studies have indicated that chronic hyperkalemia may contribute to the development of neuropathy in CKD. This study was undertaken to determine whether dietary restriction of potassium intake may be a neuroprotective factor in CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      A 24-month prospective, single-blind, randomized, controlled trial was undertaken in 47 consecutively recruited patients with stages 3 and 4 CKD. The intervention arm (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =23) was prescribed a diet focusing on potassium restriction to meet a monthly serum potassium level of \u22644.5 mEq\/L, with oral sodium polystyrene sulfonate provided if dietary advice failed to achieve the target. The control arm (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =24) received dietary advice regarding general nutrition. The primary outcome was the change in the total neuropathy score evaluated by a blinded observer. Secondary outcomes included electrolyte levels, gait speed, neurophysiologic parameters, and health-related quality of life scores. Five patients withdrew before initiation of treatment, and final analysis consisted of\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =21 in each group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a greater increase in total neuropathy score from baseline to final assessment in the control arm compared with the intervention arm (6.1\u00b16.2\u20138.6\u00b17.9 controls; 7.8\u00b17.4\u20138.2\u00b17.5 intervention; change 2.8\u00b13.3\u20130.4\u00b12.2, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). The intervention significantly reduced mean serum potassium compared with controls (4.6\u00b10.1\u20134.8\u00b10.1 mEq\/L mean recorded every 6 months over the trial duration;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.03). There were no adverse changes in other nutritional parameters. Improved gait speed was also noted in the intervention arm compared with the control arm, with a mean increase of 0.15\u00b10.17 m\/s in the intervention group versus 0.02\u00b10.16 m\/s in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results provide important preliminary evidence that dietary potassium restriction confers neuroprotection in CKD and should be confirmed in a larger multicenter trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.00670117","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T20:25:50Z","timestamp":1505161550000},"page":"1569-1577","source":"Crossref","is-referenced-by-count":68,"title":["Randomized, Controlled Trial of the Effect of Dietary Potassium Restriction on Nerve Function in CKD"],"prefix":"10.2215","volume":"12","author":[{"given":"Ria","family":"Arnold","sequence":"first","affiliation":[{"name":"School of Medical Sciences and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Pianta","sequence":"additional","affiliation":[{"name":"Northern Clinical School, University of Melbourne, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Pussell","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, UNSW Sydney, Sydney, Australia;"},{"name":"Departments of Nephrology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Kirby","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics, Prince of Wales Hospital, Sydney, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council Clinical Trials Centre and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sullivan","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council Clinical Trials Centre and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Holyday","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council Clinical Trials Centre and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cormack","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, UNSW Sydney, Sydney, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun V.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Nutrition and Dietetics, Prince of Wales Hospital, Sydney, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1523-1755.2003.00704.x","article-title":"Muscle atrophy in patients receiving hemodialysis: Effects on muscle strength, muscle quality, and physical function.","volume":"63","author":"Johansen","year":"2003","journal-title":"Kidney Int"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1053\/ajkd.2003.50055","article-title":"Decreased survival among sedentary patients undergoing dialysis: Results 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