{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:43:22Z","timestamp":1786373002776,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"abstract":"Summary<\/jats:title>\n \n Background and objectives<\/jats:title>\n Awareness of chronic kidney disease (CKD) among providers and patients is low. Whether clinical cues prompt recognition of CKD is unknown. We examined whether markers of kidney disease that should trigger CKD recognition among providers are associated with higher individual CKD awareness.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n CKD awareness was assessed in 1852 adults with an estimated GFR <60 ml\/min per 1.73 m\n 2<\/jats:sup>\n using 1999 to 2008 National Health and Nutrition Examination Survey data. CKD awareness was a \u201cyes\u201d answer to \u201cHave you ever been told you have weak or failing kidneys?\u201d Participants were grouped by distribution of the following abnormal markers of CKD: hyperkalemia, acidosis, hyperphosphatemia, elevated blood urea nitrogen, anemia, albuminuria, and uncontrolled hypertension. Odds of CKD awareness associated with each abnormal marker and groupings of markers were estimated by multivariable logistic regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among individuals with kidney disease, only those with albuminuria had greater odds of CKD awareness (adjusted odds ratio, 4.0,\n P<\/jats:italic>\n < 0.01) than those without. Odds of CKD awareness increased with each additional manifested clinical marker of CKD (adjusted odds ratio, 1.3,\n P<\/jats:italic>\n = 0.05). Nonetheless, 90% of individuals with two to four markers of CKD and 84% of individuals with \u22655 markers of CKD were unaware of their disease.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Although individuals who manifest many markers of kidney dysfunction are more likely to be aware of their CKD, their CKD awareness remains low. A better understanding of mechanisms of awareness is required to facilitate earlier detection of CKD and implement therapy to minimize associated complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.00730111","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T21:42:28Z","timestamp":1311370948000},"page":"1838-1844","source":"Crossref","is-referenced-by-count":130,"title":["Chronic Kidney Disease Awareness Among Individuals with Clinical Markers of Kidney Dysfunction"],"prefix":"10.2215","volume":"6","author":[{"given":"Delphine S.","family":"Tuot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Plantinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilka R\u00edos","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hedgeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Saran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Powe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20230811","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1001\/archinte.168.20.2268","article-title":"Patient awareness of chronic kidney disease: Trends and predictors","volume":"168","author":"Plantinga","year":"2008","journal-title":"Arch Intern Med"},{"key":"R2-8-20230811","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention","volume":"42","author":"Sarnak","year":"2003","journal-title":"Hypertension"},{"key":"R3-8-20230811","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1097\/01.ASN.0000070156.78824.C7","article-title":"National kidney disease education program","volume":"14","author":"Hostetter","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R4-8-20230811","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s11606-009-1086-6","article-title":"Perceived susceptibility to chronic kidney disease among high-risk patients seen in primary care practices","volume":"24","author":"Boulware","year":"2009","journal-title":"J Gen Intern Med"},{"key":"R5-8-20230811","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1053\/j.ajkd.2007.12.020","article-title":"Attitudes and behaviors of African Americans regarding early detection of kidney disease","volume":"51","author":"Waterman","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"R6-8-20230811","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/j.ajkd.2008.08.035","article-title":"Prevalence and awareness of CKD among African Americans: The Jackson Heart Study","volume":"53","author":"Flessner","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"R7-8-20230811","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1053\/j.ajkd.2009.01.004","article-title":"Diabetes mellitus and CKD awareness: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES)","volume":"53","author":"Whaley-Connell","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"R8-8-20230811","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000148645","article-title":"Chronic kidney disease is often unrecognized among patients with coronary heart disease: The REGARDS Cohort Study","volume":"29","author":"McClellan","year":"2009","journal-title":"Am J Nephrol"},{"key":"R9-8-20230811","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/S0895-4356(01)00450-4","article-title":"Patient- and provider-reported adherence: Toward a clinically useful approach to measuring antiretroviral adherence","volume":"54","author":"Wagner","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"R10-8-20230811","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.ajkd.2006.04.073","article-title":"Identification and referral of patients with progressive CKD: A national study","volume":"48","author":"Boulware","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"R12-8-20230811","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.ajkd.2007.08.020","article-title":"Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988\u20131994, 1999\u20132004","volume":"50","author":"Selvin","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"R14-8-20230811","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1681\/ASN.V1341034","article-title":"Use of the albumin\/creatinine ratio to detect microalbuminuria: implications of sex and race","volume":"13","author":"Mattix","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R17-8-20230811","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"key":"R18-8-20230811","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"R19-8-20230811","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1681\/ASN.2008121270","article-title":"Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes","volume":"20","author":"Ninomiya","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R20-8-20230811","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1001\/archinte.167.22.2490","article-title":"Association of kidney function and albuminuria with cardiovascular mortality in older vs younger individuals: The HUNT II Study","volume":"167","author":"Hallan","year":"2007","journal-title":"Arch Intern Med"},{"key":"R21-8-20230811","doi-asserted-by":"crossref","first-page":"c19","DOI":"10.1159\/000314545","article-title":"Chronic Kidney Disease in Older People: Physiology, Pathology or Both?","volume":"116","author":"Abdelhafiz","year":"2010","journal-title":"Nephron Clin Pract"},{"key":"R22-8-20230811","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1681\/ASN.2007040422","article-title":"Age affects outcomes in chronic kidney disease","volume":"18","author":"O'Hare","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R23-8-20230811","first-page":"147","article-title":"The self-management experience of people with mild to moderate chronic kidney disease","volume":"35","author":"Costantini","year":"2008","journal-title":"Nephrol Nurs J"},{"key":"R24-8-20230811","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.mcna.2004.11.005","article-title":"Executing change in the management of chronic kidney disease: Perspectives on guidelines and practice","volume":"89","author":"Levin","year":"2005","journal-title":"Med Clin North Am"},{"key":"R25-8-20230811","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1053\/j.ajkd.2008.06.022","article-title":"Awareness and knowledge of clinical practice guidelines for CKD among internal medicine residents: A national online survey","volume":"52","author":"Agrawal","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"R26-8-20230811","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1053\/j.ajkd.2008.05.038","article-title":"The National Kidney Disease Education Program: Improving understanding, detection, and management of CKD","volume":"53","author":"Narva","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"R27-8-20230811","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"R28-8-20230811","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2215\/CJN.07891109","article-title":"Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes","volume":"5","author":"Plantinga","year":"2010","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201108000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:41:03Z","timestamp":1786369263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201108000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.00730111","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}