{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:50Z","timestamp":1786373090112,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Clinical heart failure (HF) is associated with CKD and faster rates of kidney function decline. Whether subclinical abnormalities of cardiac structure are associated with faster kidney function decline is not known. The association between cardiac concentricity and kidney function decline was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      This is a longitudinal study of 3866 individuals from the Multi-Ethnic Study of Atherosclerosis (2000\u20132007) who were free of clinical cardiovascular disease, with an estimated GFR (eGFR) \u226560 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      at baseline and 5 years of follow-up. Concentricity, a measurement of abnormal cardiac size, was assessed by magnetic resonance imaging and evaluated as a continuous measurement and in quartiles. GFR was estimated by creatinine (eGFRcr) and cystatin C (eGFRcys). The association of concentricity with annual eGFR decline, incident CKD, and rapid kidney function decline (&gt;5% per year) was investigated using linear mixed models as well as Poisson and logistic regression, respectively. Analyses adjusted for demographics, BP, diabetes, and inflammatory markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median decline was \u22120.8 (interquartile range, \u22123.1, \u22120.5) by eGFRcr. Compared with the lowest quartile of concentricity, persons in the highest quartile had an additional 21% (9%\u201332%) decline in mean eGFRcr in fully adjusted models. Concentricity was also associated with incident CKD and with rapid kidney function decline after adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Subclinical abnormalities in cardiac structure are associated with longitudinal kidney function decline independent of diabetes and hypertension. Future studies should examine mechanisms to explain these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.01230212","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T20:17:29Z","timestamp":1336767449000},"page":"1137-1144","source":"Crossref","is-referenced-by-count":26,"title":["Subclinical Cardiac Abnormalities and Kidney Function Decline"],"prefix":"10.2215","volume":"7","author":[{"given":"Meyeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashish","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Peralta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20230811","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0735-1097(03)00163-3","article-title":"Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals.","volume":"41","author":"Fried","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R2-13-20230811","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med"},{"key":"R3-13-20230811","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.atherosclerosis.2008.08.016","article-title":"Clinical and subclinical cardiovascular disease and kidney function decline in the elderly.","volume":"204","author":"Shlipak","year":"2009","journal-title":"Atherosclerosis"},{"key":"R4-13-20230811","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","article-title":"Cardiorenal syndrome.","volume":"52","author":"Ronco","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R5-13-20230811","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0272-6386(99)70118-6","article-title":"Left ventricular mass index increase in early renal disease:Impact of decline in hemoglobin.","volume":"34","author":"Levin","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"R6-13-20230811","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/j.ajkd.2008.06.012","article-title":"Left ventricular hypertrophy in mild and moderate reduction in kidney function determined using cardiac magnetic resonance imaging and cystatin C: The multi-ethnic study of atherosclerosis (MESA).","volume":"52","author":"Moran","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"R7-13-20230811","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.jacc.2003.11.064","article-title":"Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years: The Cardiovascular Health Study.","volume":"43","author":"Drazner","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"R8-13-20230811","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0735-1097(00)00582-9","article-title":"Predictors of congestive heart failure in the elderly: The Cardiovascular Health Study.","volume":"35","author":"Gottdiener","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"R9-13-20230811","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","article-title":"The progression from hypertension to congestive heart failure.","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA"},{"key":"R10-13-20230811","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.2215\/CJN.04660511","article-title":"Echocardiographic parameters are independently associated with rate of renal function decline and progression to dialysis in patients with chronic kidney disease.","volume":"6","author":"Chen","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R11-13-20230811","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0735-1097(94)00473-4","article-title":"Prognosis of left ventricular geometric patterns in the Framingham Heart Study.","volume":"25","author":"Krumholz","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"R12-13-20230811","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.jacc.2008.09.014","article-title":"The relationship of left ventricular mass and geometry to incident cardiovascular events: The MESA (Multi-Ethnic Study of Atherosclerosis) study.","volume":"52","author":"Bluemke","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R13-13-20230811","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archinte.167.11.1130","article-title":"Cardiovascular disease and subsequent kidney disease.","volume":"167","author":"Elsayed","year":"2007","journal-title":"Arch Intern Med"},{"key":"R14-13-20230811","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis: Objectives and design.","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"key":"R15-13-20230811","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00019501-200509000-00002","article-title":"Cardiovascular magnetic resonance in the quantitative assessment of left ventricular mass, volumes and contractile function.","volume":"16","author":"Lyne","year":"2005","journal-title":"Coron Artery Dis"},{"key":"R16-13-20230811","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.2214\/AJR.04.1868","article-title":"Cardiovascular function in multi-ethnic study of atherosclerosis: Normal values by age, sex, and ethnicity.","volume":"186","author":"Natori","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"R17-13-20230811","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"R18-13-20230811","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/diacare.26.2007.S5","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus.","volume":"26","author":"Genuth","year":"2003","journal-title":"Diabetes Care"},{"key":"R19-13-20230811","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"R20-13-20230811","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/j.ajkd.2007.11.018","article-title":"Estimating GFR using serum cystatin C alone and in combination with serum creatinine: A pooled analysis of 3,418 individuals with CKD.","volume":"51","author":"Stevens","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"R21-13-20230811","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1681\/ASN.2009050546","article-title":"Rapid decline of kidney function increases cardiovascular risk in the elderly.","volume":"20","author":"Shlipak","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R22-13-20230811","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data.","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"R23-13-20230811","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/aje\/kwn392","article-title":"The differential association of kidney dysfunction with small and large arterial elasticity: The multiethnic study of atherosclerosis.","volume":"169","author":"Peralta","year":"2009","journal-title":"Am J Epidemiol"},{"key":"R24-13-20230811","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1254\/jphs.08R02CR","article-title":"Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury.","volume":"108","author":"Kiyomoto","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"R25-13-20230811","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/aje\/kwp319","article-title":"Structural and functional vascular alterations and incident hypertension in normotensive adults: The Multi-Ethnic Study of Atherosclerosis.","volume":"171","author":"Peralta","year":"2010","journal-title":"Am J Epidemiol"},{"key":"R26-13-20230811","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1161\/01.CIR.89.4.1717","article-title":"Left ventricular mass and subsequent blood pressure changes among middle-aged men in rural and urban Japanese populations.","volume":"89","author":"Iso","year":"1994","journal-title":"Circulation"},{"key":"R27-13-20230811","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/aje\/kwq509","article-title":"Association of left ventricular hypertrophy with incident hypertension: The multi-ethnic study of atherosclerosis.","volume":"173","author":"Shimbo","year":"2011","journal-title":"Am J Epidemiol"},{"key":"R28-13-20230811","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1046\/j.1523-1755.2003.00273.x","article-title":"Role of excess volume in the pathophysiology of hypertension in chronic kidney disease.","volume":"64","author":"Vasavada","year":"2003","journal-title":"Kidney Int"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201207000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:42:12Z","timestamp":1786369332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201207000-00013"}},"subtitle":["The Multi-Ethnic Study of Atherosclerosis"],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.01230212","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}