{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:11Z","timestamp":1788306731990,"version":"build-2803163510"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","funder":[{"name":"Capital Health Development Research Project of China","award":["2018-2-4073"],"award-info":[{"award-number":["2018-2-4073"]}]},{"name":"Beijing Science and Technology Plan Project of China","award":["D181100000118003"],"award-info":[{"award-number":["D181100000118003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670649"],"award-info":[{"award-number":["81670649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925006"],"award-info":[{"award-number":["81925006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019-I2M-5-046"],"award-info":[{"award-number":["2019-I2M-5-046"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Poly-IgA immune complex formation and glomerular deposition play a key role in IgA nephropathy. Our study sought to develop a new methodology for one-step serologic detection of poly-IgA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>A novel ELISA method using recombinant CD89 as a \u201ccapturing\u201d probe was established for detecting poly-IgA immune complex in plasma. We applied semiquantitative measurements of these poly-IgA indices in patients recruited at Peking University First Hospital who had IgA nephropathy or other kidney disease types, as compared with healthy controls. The longitudinal trend of the poly-IgA index and the association with pathologic parameters and treatment responses were evaluated. Finally, we analyzed the molecular composition of poly-IgA complexes in patients by mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Recombinant CD89\u2013mounted ELISA plates specifically captured plasma poly-IgA. The levels of poly-IgA immune complex (26.7 [interquartile range (IQR) 17.1\u201342.6] U\/ml) in IgA nephropathy were significantly higher than those in healthy controls (15.5 [IQR 10.7\u201320.0] U\/ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) or in controls with non-IgA nephropathy disease (14.8 [IQR 10.5\u201321.9] U\/ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Higher levels of poly-IgA immune complex were associated with lower eGFR and worse kidney outcome. Accuracy parameters and concordant statistics showed good discrimination between IgA nephropathy and healthy controls based on poly-IgA index levels (area under the curve [AUC], 0.78; 95% confidence interval [95% CI], 0.72 to 0.83;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), significantly outperforming galactose-deficient IgA1 levels (AUC, 0.70;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.05). Corticosteroid and immunosuppressant treatments lowered poly-IgA indices. After a recombinant CD89\u2013directed workflow in conjunction with mass spectrometry, we also analyzed the molecular composition of IgA immune complex in patients with IgA nephropathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher level of recombinant CD89\u2013bound poly-IgA immune complex was associated with the severity of the disease and with treatment response to steroids and immunosuppressants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.01300121","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T15:45:51Z","timestamp":1633362351000},"page":"1652-1664","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Poly-IgA Complexes and Disease Severity in IgA Nephropathy"],"prefix":"10.2215","volume":"16","author":[{"given":"Xue","family":"Zhang","sequence":"first","affiliation":[{"name":"Renal Division, Peking University First Hospital, Beijing, China"},{"name":"Peking University Institute of Nephrology, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China"},{"name":"Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Lv","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Beijing, China"},{"name":"Peking University Institute of Nephrology, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China"},{"name":"Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-652X","authenticated-orcid":false,"given":"Pan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0872-2986","authenticated-orcid":false,"given":"Xinfang","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manliu","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Beijing, China"},{"name":"Peking University Institute of Nephrology, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China"},{"name":"Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Proteomics Laboratory, Medical and Health Analytical Center, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Beijing, China"},{"name":"Peking University Institute of Nephrology, Beijing, China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"},{"name":"Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China"},{"name":"Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, 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