{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:16Z","timestamp":1791618976630,"version":"4.3.4"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10\u201359 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      using multivariable-adjusted Cox proportional hazards models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline sleep duration and PSQI global score for the 1601 patients were mean\u00b1SD 7.0\u00b11.3 hours and median 4 (interquartile range, 3\u20137), respectively. Poor sleep quality (PSQI global score \u22656) was common (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =588 [37%]). During a median of 4.0 (2.6\u20134.3) years of the follow-up period, 282 (18%) patients progressed to ESKD. After adjusting for age, sex, eGFR, urinary albumin excretion, smoking status, body mass index, history of diabetes and cardiovascular disease, systolic BP, blockade of the renin-angiotensin system, use of hypnotics, and Beck depression inventory score, both shorter (\u22645 hour) and longer (&gt;8 hour) sleep duration were associated with ESKD (adjusted hazard ratios [95% confidence intervals] for \u22645.0, 5.1\u20136.0, 6.1\u20137.0, 7.1\u20138.0, and \u22658.0 hours were 2.05 [1.31 to3.21], 0.98 [0.67 to 1.44], 1.00 [reference], 1.22 [0.89 to 1.66], and 1.48 [1.01 to 2.16]), suggesting a U-shaped relationship between sleep duration and ESKD. PSQI global score \u22656 was also associated with incidence of ESKD (adjusted hazard ratios [95% confidence intervals] for PSQI global score \u22645 and \u22656 were 1.00 [reference] and 1.33 [1.03 to 1.71]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Shorter (\u22645 hour) and longer (&gt;8 hour) sleep duration and poor sleep quality (PSQI global score \u22656) were associated with ESKD in patients with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.01340118","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T11:07:21Z","timestamp":1542280041000},"page":"1825-1832","source":"Crossref","is-referenced-by-count":85,"title":["Sleep Quality and Sleep Duration with CKD are Associated with Progression to ESKD"],"prefix":"10.2215","volume":"13","author":[{"given":"Ryohei","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Health Care Division, Health and Counseling Center, Osaka University, Toyonaka, Osaka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Shinzawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Yamakoshi","sequence":"additional","affiliation":[{"name":"Statcom Company Limited, Bunkyo-Ku, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyu","family":"Imai","sequence":"additional","affiliation":[{"name":"Nakayamadera Imai Clinic, Takarazuka, Hyogo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Chuo University Bunkyo-ku, Tokyo, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hishida","sequence":"additional","affiliation":[{"name":"Yaizu City Hospital, Yaizu, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CKD-JAC Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.1016\/S2214-109X(16)30049-3","article-title":"Chronic kidney disease from screening, detection, and awareness, to prevention.","volume":"4","author":"Sherwood","year":"2016","journal-title":"Lancet Glob Health"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ki.2010.550","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. 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