{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:40:09Z","timestamp":1786372809333,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n Background and objectives<\/jats:title>\n Marijuana use has become more widely accepted in the United States and has been legalized in many areas. Although it is biologically plausible that marijuana could affect kidney function, epidemiologic data are lacking.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n We conducted a cohort study among young adults with preserved eGFR (\n i.e.<\/jats:italic>\n , eGFR\u226560 ml\/min per 1.73 m\n 2<\/jats:sup>\n ) using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. At scheduled examinations occurring every 5 years and starting at study year 10 (calendar years, 1995\u20131996), cystatin C was collected over a 10-year period, and urine albumin-to-creatinine ratio was collected over a 15-year period. We investigated the cross-sectional association between current and cumulative marijuana use (in marijuana-years; one marijuana-year equals 365 days of marijuana use) and eGFR by cystatin C (eGFR\n cys<\/jats:sub>\n ) at year 10. In longitudinal analyses, we investigated the association between cumulative marijuana use and eGFR\n cys<\/jats:sub>\n change and rapid (\u22653%\/year) eGFR\n cys<\/jats:sub>\n decline over two 5-year intervals and prevalent albuminuria (urine albumin-to-creatinine ratio \u226530 mg\/g) over a 15-year period.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Past or current marijuana use was reported by 83% (3131 of 3765) of the cohort, and the mean eGFR\n cys<\/jats:sub>\n was 111 ml\/min per 1.73 m\n 2<\/jats:sup>\n at year 10. Over the following 10 years, 504 had rapid eGFR\n cys<\/jats:sub>\n decline, and over the following 15 years, 426 had prevalent albuminuria. Compared with no use, daily current use and \u22655 marijuana-years of cumulative use were associated with lower eGFR\n cys<\/jats:sub>\n at year 10: \u22124.5% (95% confidence interval, \u22128.1 to \u22120.7%;\n P<\/jats:italic>\n =0.02) and \u22123.0% (95% confidence interval, \u22125.6 to \u22120.4%;\n P<\/jats:italic>\n =0.03), respectively. Marijuana use was not significantly associated with eGFR\n cys<\/jats:sub>\n change, rapid eGFR\n cys<\/jats:sub>\n decline, or prevalent albuminuria.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although we identified a modest cross-sectional association between higher marijuana exposure and lower eGFR\n cys<\/jats:sub>\n among young adults with preserved eGFR, our findings were largely null and did not demonstrate a longitudinal association between marijuana use and eGFR\n cys<\/jats:sub>\n change, rapid eGFR\n cys<\/jats:sub>\n decline, or prevalent albuminuria.\n <\/jats:p>\n <\/jats:sec>\n \n Podcast<\/jats:title>\n This article contains a podcast at https:\/\/www.asn-online.org\/media\/podcast\/CJASN\/2017_08_24_CJASNPodcast_17_10.mp3<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.01530217","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T20:20:10Z","timestamp":1503606010000},"page":"1578-1587","source":"Crossref","is-referenced-by-count":23,"title":["Marijuana Use and Estimated Glomerular Filtration Rate in Young Adults"],"prefix":"10.2215","volume":"12","author":[{"given":"Julie H.","family":"Ishida","sequence":"first","affiliation":[{"name":"Medicine and"},{"name":"Division of Nephrology, San Francisco Veterans Affairs Medical Center, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Auer","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care, University of Bern, Bern, Switzerland;"},{"name":"Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Pletcher","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared P.","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente, Oakland, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten L.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California;"},{"name":"Division of Nephrology, San Francisco Veterans Affairs Medical Center, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bibbins-Domingo","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Epidemiology and Biostatistics, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Peralta","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Division of Nephrology, San Francisco Veterans Affairs Medical Center, San Francisco, California;"},{"name":"Kidney Health Research Collaborative, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Medicine and"},{"name":"Kidney Health Research Collaborative, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/jamapsychiatry.2015.1858","article-title":"Prevalence of marijuana use disorders in the united states between 2001-2002 and 2012-2013.","volume":"72","author":"Hasin","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1037\/a0027622","article-title":"Prevalence of cannabis use disorder diagnoses among veterans in 2002, 2008, and 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