{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:26:51Z","timestamp":1790915211386,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n Background and objectives<\/jats:title>\n Fibrosis is a major cause of kidney allograft injury. Currently, the only means of assessing allograft fibrosis is by biopsy, an invasive procedure that samples <1% of the kidney. We examined whether magnetic resonance elastography, an imaging-based measure of organ stiffness, could noninvasively estimate allograft fibrosis and predict progression of allograft dysfunction.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n Kidney allograft recipients >1 year post-transplant undergoing an allograft biopsy first underwent free-breathing, flow-compensated magnetic resonance elastography on a 3.0-T magnetic resonance imaging scanner. Each patient had serial eGFR measurements after the elastography scan for a follow-up period of up to 1 year. The mean stiffness value of the kidney allograft was compared with both the histopathologic Banff fibrosis score and the rate of eGFR change during the follow-up period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixteen patients who underwent magnetic resonance elastography and biopsy were studied (mean age: 54\u00b19 years old). Whole-kidney mean stiffness ranged between 3.5 and 7.3 kPa. Whole-kidney stiffness correlated with biopsy-derived Banff fibrosis score (Spearman rho =0.67;\n P<\/jats:italic>\n <0.01). Stiffness was heterogeneously distributed within each kidney, providing a possible explanation for the lack of a stronger stiffness-fibrosis correlation. We also found negative correlations between whole-kidney stiffness and both baseline eGFR (Spearman rho =\u22120.65;\n P<\/jats:italic>\n <0.01) and eGFR change over time (Spearman rho =\u22120.70;\n P<\/jats:italic>\n <0.01). Irrespective of the baseline eGFR, increased kidney stiffness was associated with a greater eGFR decline (regression\n r<\/jats:italic>\n 2<\/jats:sup>\n =0.48;\n P<\/jats:italic>\n =0.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Given the limitations of allograft biopsy, our pilot study suggests the potential for magnetic resonance elastography as a novel noninvasive measure of whole-allograft fibrosis burden that may predict future changes in kidney function. Future studies exploring the utility and accuracy of magnetic resonance elastography are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.01830217","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T20:25:21Z","timestamp":1504124721000},"page":"1671-1679","source":"Crossref","is-referenced-by-count":66,"title":["Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts"],"prefix":"10.2215","volume":"12","author":[{"given":"Anish","family":"Kirpalani","sequence":"first","affiliation":[{"name":"Medical Imaging and"},{"name":"Li Ka Shing Knowledge Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyesha","family":"Hashim","sequence":"additional","affiliation":[{"name":"Medical Imaging and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"General","family":"Leung","sequence":"additional","affiliation":[{"name":"Medical Imaging and"},{"name":"Li Ka Shing Knowledge Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Imaging and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Krizova","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Jothy","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Deeb","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, St. Michael\u2019s Hospital and University of Toronto, Toronto, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan N.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Medical Imaging 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