{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:05:14Z","timestamp":1791230714544,"version":"4.1.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Background and objectives<\/jats:title>\n The incidence of atrial fibrillation is high in ESRD, but limited data are available on the incidence of atrial fibrillation across a broad range of kidney function. Thus, we examined the association of eGFR and urine albumin-to-creatinine ratio with risk of incident atrial fibrillation.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n We meta-analyzed three prospective cohorts: the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study. Cox regression models were performed examining the association of eGFR and urine albumin-to-creatinine ratio with incident atrial fibrillation adjusting for demographics and comorbidity. In additional analyses, we adjusted for measures of subclinical cardiovascular disease (by electrocardiogram and cardiac imaging) and interim heart failure and myocardial infarction events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the meta-analyzed study population of 16,769 participants without prevalent atrial fibrillation, across categories of decreasing eGFR (eGFR>90 [reference], 60\u201389, 45\u201359, 30\u201344, and <30 ml\/min per 1.73 m\n 2<\/jats:sup>\n ), there was a stepwise increase in the adjusted risk of incident atrial fibrillation: hazard ratios (95% confidence intervals) were 1.00, 1.09 (0.97 to 1.24), 1.17 (1.00 to 1.38), 1.59 (1.28 to 1.98), and 2.03 (1.40 to 2.96), respectively. There was a stepwise increase in the adjusted risk of incident atrial fibrillation across categories of increasing urine albumin-to-creatinine ratio (urine albumin-to-creatinine ratio <15 [reference], 15\u201329, 30\u2013299, and \u2265300 mg\/g): hazard ratios (95% confidence intervals) were 1.00, 1.04 (0.83 to 1.30), 1.47 (1.20 to 1.79), and 1.76 (1.18 to 2.62), respectively. The associations were consistent after adjustment for subclinical cardiovascular disease measures and interim heart failure and myocardial infarction events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this meta-analysis of three cohorts, reduced eGFR and elevated urine albumin-to-creatinine ratio were significantly associated with greater risk of incident atrial fibrillation, highlighting the need for further studies to understand mechanisms linking kidney disease with atrial fibrillation.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.01860217","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T20:25:22Z","timestamp":1502396722000},"page":"1386-1398","source":"Crossref","is-referenced-by-count":120,"title":["eGFR and Albuminuria in Relation to Risk of Incident Atrial Fibrillation: A Meta-Analysis of the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study"],"prefix":"10.2215","volume":"12","author":[{"given":"Nisha","family":"Bansal","sequence":"first","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila R.","family":"Zelnick","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine and School of Public Health, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"},{"name":"Veterans Affairs Puget Sound Health Care System, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Deo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Kestenbaum","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehu","family":"Mathew","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassianne","family":"Robinson-Cohen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Sarnak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Kidney Health Research Collaborative, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nona","family":"Sotoodehnia","sequence":"additional","affiliation":[{"name":"Division of Cardiology,"},{"name":"Cardiovascular Health Research Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessie","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kidney Research Institute,"},{"name":"Veterans Affairs Puget Sound Health Care System, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, and"},{"name":"Department of Epidemiology, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ki.2009.477","article-title":"Atrial fibrillation in hemodialysis patients: Clinical features and associations with anticoagulant therapy.","volume":"77","author":"Wizemann","year":"2010","journal-title":"Kidney Int"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ki.2011.416","article-title":"The prevalence of and factors associated with chronic atrial fibrillation in medicare\/medicaid-eligible dialysis patients.","volume":"81","author":"Wetmore","year":"2012","journal-title":"Kidney Int"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1053\/j.ajkd.2005.07.044","article-title":"Prevalence of atrial fibrillation and associated factors in a population of long-term hemodialysis patients.","volume":"46","author":"Genovesi","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1681\/ASN.2010050459","article-title":"The increasing prevalence of atrial fibrillation among hemodialysis patients.","volume":"22","author":"Winkelmayer","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B5-20230813","first-page":"15","article-title":"Acute pulmonary embolism: Analysis of consecutive 353 patients hospitalised in a single centre. 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