{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:45:12Z","timestamp":1786373112447,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"Summary<\/jats:title>\n \n Background and objectives<\/jats:title>\n Mineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001\u2013June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The 11,776 patients were aged 47\u00b114 years and 39% were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80\u2013120 U\/L, recipients with pretransplant serum alkaline phosphatase of 120\u2013160 and \u2265160 U\/L had 49% and 64% higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150\u2013300 pg\/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH \u2265800 pg\/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U\/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.01910212","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T01:42:12Z","timestamp":1346982132000},"page":"1859-1871","source":"Crossref","is-referenced-by-count":36,"title":["Association of Pre\u2013Kidney Transplant Markers of Mineral and Bone Disorder with Post-Transplant Outcomes"],"prefix":"10.2215","volume":"7","author":[{"given":"Miklos Z.","family":"Molnar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba P.","family":"Kovesdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Mucsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro B.","family":"Salusky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Kalantar-Zadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20230811","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis.","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R2-17-20230811","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1523-1755.2005.00185.x","article-title":"Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns Study.","volume":"67","author":"Young","year":"2005","journal-title":"Kidney Int"},{"key":"R3-17-20230811","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1681\/ASN.2004040275","article-title":"Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: The USRDS waves 1, 3, and 4 study.","volume":"16","author":"Slinin","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R4-17-20230811","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/ndt\/gfr747","article-title":"Mineral and bone disorders and survival in hemodialysis patients with and without polycystic kidney disease.","volume":"27","author":"Lukowsky","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R5-17-20230811","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2215\/CJN.06091108","article-title":"Association of serum alkaline phosphatase with coronary artery calcification in maintenance hemodialysis patients.","volume":"4","author":"Shantouf","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"R6-17-20230811","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.atherosclerosis.2009.11.013","article-title":"Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients.","volume":"210","author":"Shoji","year":"2010","journal-title":"Atherosclerosis"},{"key":"R7-17-20230811","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ncpcardio0725","article-title":"Interaction of vascular and bone disease in patients with normal renal function and patients undergoing dialysis.","volume":"4","author":"Raggi","year":"2007","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"R8-17-20230811","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1681\/ASN.2008010014","article-title":"Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients.","volume":"19","author":"Regidor","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"R9-17-20230811","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1523-1755.1999.00575.x","article-title":"Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure.","volume":"56","author":"Rostand","year":"1999","journal-title":"Kidney Int"},{"key":"R10-17-20230811","doi-asserted-by":"crossref","first-page":"V2","DOI":"10.1093\/ndt\/gfh1049","article-title":"The clinical consequences of secondary hyperparathyroidism: Focus on clinical outcomes.","volume":"19","author":"H\u00f6rl","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"R11-17-20230811","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1097\/00007890-200206270-00013","article-title":"The changing causes of graft loss and death after kidney transplantation.","volume":"73","author":"Howard","year":"2002","journal-title":"Transplantation"},{"key":"R12-17-20230811","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.2215\/CJN.06190611","article-title":"Association of pretransplant serum phosphorus with posttransplant outcomes.","volume":"6","author":"Sampaio","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R13-17-20230811","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/01.tp.0000228923.75739.88","article-title":"High pretransplant parathyroid hormone levels increase the risk for graft failure after renal transplantation.","volume":"82","author":"Roodnat","year":"2006","journal-title":"Transplantation"},{"key":"R15-17-20230811","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/TP.0b013e31819cd122","article-title":"Elevated serum phosphate predicts mortality in renal transplant recipients.","volume":"87","author":"Connolly","year":"2009","journal-title":"Transplantation"},{"key":"R16-17-20230811","first-page":"54","article-title":"Pre-transplant calcium-phosphate-parathormone homeostasis as a risk factor for early graft dysfunction.","volume":"19","author":"Ahmadi","year":"2008","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"R17-17-20230811","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/01.TP.0000116417.03114.87","article-title":"Calcium levels as a risk factor for delayed graft function.","volume":"77","author":"Boom","year":"2004","journal-title":"Transplantation"},{"key":"R18-17-20230811","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.transproceed.2006.01.032","article-title":"Pretransplant calcium levels have no predictive value for delayed graft function, long-term graft function, cardiovascular events, or graft and patient survival in renal transplantation.","volume":"38","author":"Kr\u00fcger","year":"2006","journal-title":"Transplant Proc"},{"key":"R19-17-20230811","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ki.2011.114","article-title":"Higher recipient body mass index is associated with post-transplant delayed kidney graft function.","volume":"80","author":"Molnar","year":"2011","journal-title":"Kidney Int"},{"key":"R21-17-20230811","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2215\/CJN.09131010","article-title":"Associations of pretransplant weight and muscle mass with mortality in renal transplant recipients.","volume":"6","author":"Streja","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R22-17-20230811","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.2337\/dc11-0906","article-title":"Association of pretransplant glycemic control with posttransplant outcomes in diabetic kidney transplant recipients.","volume":"34","author":"Molnar","year":"2011","journal-title":"Diabetes Care"},{"key":"R23-17-20230811","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2215\/CJN.07110711","article-title":"Dialysis modality and outcomes in kidney transplant recipients.","volume":"7","author":"Molnar","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"R24-17-20230811","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/clinchem\/33.8.1364","article-title":"Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.","volume":"33","author":"Nussbaum","year":"1987","journal-title":"Clin Chem"},{"key":"R25-17-20230811","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1093\/ndt\/gfn158","article-title":"Marked variation in the definition and diagnosis of delayed graft function: A systematic review.","volume":"23","author":"Yarlagadda","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"R26-17-20230811","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3945\/ajcn.2008.26665","article-title":"Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?","volume":"88","author":"Shinaberger","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"R27-17-20230811","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ki.2008.35","article-title":"Vitamin D receptor activation and survival in chronic kidney disease.","volume":"73","author":"Kovesdy","year":"2008","journal-title":"Kidney Int"},{"key":"R28-17-20230811","first-page":"295","article-title":"The environment and disease: Association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc R Soc Med"},{"key":"R29-17-20230811","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1525-139X.2007.00360.x","article-title":"What is so bad about reverse epidemiology anyway?","volume":"20","author":"Kalantar-Zadeh","year":"2007","journal-title":"Semin Dial"},{"key":"R30-17-20230811","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1096\/fj.01-0433rev","article-title":"Vitamin D: Its role and uses in immunology.","volume":"15","author":"Deluca","year":"2001","journal-title":"FASEB J"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201211000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:42:30Z","timestamp":1786369350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201211000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.01910212","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}