{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:35:34Z","timestamp":1790660134004,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Kidneys from elderly deceased donors are often discarded after procurement if the expected outcomes from single kidney transplantation are considered unacceptable. An alternative is to consider them for dual kidney transplantation. We aimed to examine the utilization of kidneys from donors aged \u226560 years in the United Kingdom and compare clinical outcomes of dual versus single kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>Data from the United Kingdom Transplant Registry from 2005 to 2017 were analyzed. We examined utilization rates of kidneys retrieved from deceased donors aged \u226560 years, and 5-year patient and death-censored graft survival of recipients of dual and single kidney transplants. Secondary outcomes included eGFR. Multivariable analyses and propensity score analysis were used to correct for differences between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 7841 kidneys were procured from deceased donors aged \u226560 years, of which 1338 (17%) were discarded; 356 dual and 5032 single kidneys were transplanted. Donors of dual transplants were older (median, 73 versus 66 years;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and had higher United States Kidney Donor Risk Indices (2.48 versus 1.98;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Recipients of dual transplants were also older (64 versus 61 years;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and had less favorable human leukocyte antigen matching (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). After adjusting for confounders, dual and single transplants had similar 5-year graft survival (hazard ratio, 0.81; 95% CI, 0.59 to 1.12). No difference in patient survival was demonstrated. Similar findings were observed in a matched cohort with a propensity score analysis method. Median 12-month eGFR was significantly higher in the dual kidney transplant group (40 versus 36 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recipients of kidneys from donors aged \u226560 years have similar 5-year graft survival and better graft function at 12 months with dual compared with single deceased donor kidney transplants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.02060220","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T22:15:10Z","timestamp":1595283310000},"page":"1320-1329","source":"Crossref","is-referenced-by-count":22,"title":["Utilization and Outcomes of Single and Dual Kidney Transplants from Older Deceased Donors in the United Kingdom"],"prefix":"10.2215","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-4478","authenticated-orcid":false,"given":"Maria","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Nephrology and Transplantation, Guy\u2019s and St Thomas\u2019 National Health Service Foundation Trust, London, United Kingdom"},{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"},{"name":"Faculty of Life Sciences and Medicine, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-1474","authenticated-orcid":false,"given":"George H.B.","family":"Greenhall","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation, Guy\u2019s and St Thomas\u2019 National Health Service Foundation Trust, London, United Kingdom"},{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"},{"name":"Faculty of Life Sciences and Medicine, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic M.","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Addenbrooke\u2019s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Mumford","sequence":"additional","affiliation":[{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Johnson","sequence":"additional","affiliation":[{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Nephrology, St James\u2019s University Hospital, The Leeds Teaching Hospitals National Health Service Trust, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Forsythe","sequence":"additional","affiliation":[{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Department of Surgery, Addenbrooke\u2019s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Callaghan","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation, Guy\u2019s and St Thomas\u2019 National Health Service Foundation Trust, London, United Kingdom"},{"name":"National Health Service Blood and Transplant, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"issue":"Suppl 1","key":"B1-20230813","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/01.TP.0000438215.16737.68","article-title":"Organ donation and transplantation in the UK-the last decade: A report from the UK national transplant registry","volume":"97","author":"Johnson","year":"2014","journal-title":"Transplantation"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1681\/ASN.V10122591","article-title":"Early experience with dual kidney transplantation in adults using expanded donor criteria. 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