{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:42:01Z","timestamp":1786372921576,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.2215\/cjn.02110310","type":"journal-article","created":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T23:51:02Z","timestamp":1282866662000},"page":"2305-2314","source":"Crossref","is-referenced-by-count":121,"title":["Cinacalcet Effectively Reduces Parathyroid Hormone Secretion and Gland Volume Regardless of Pretreatment Gland Size in Patients with Secondary Hyperparathyroidism"],"prefix":"10.2215","volume":"5","author":[{"given":"Hirotaka","family":"Komaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongsoo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-24-20230601","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1681\/ASN.V1161141","article-title":"Cell biology of parathyroid gland hyperplasia in chronic renal failure","volume":"11","author":"Drueke","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"R2-24-20230601","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.ki.5002287","article-title":"Development and progression of secondary hyperparathyroidism in chronic kidney disease: Lessons from molecular genetics","volume":"74","author":"Goodman","year":"2008","journal-title":"Kidney Int"},{"key":"R3-24-20230601","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/(SICI)1098-2388(199703\/04)13:2<78::AID-SSU3>3.0.CO;2-Z","article-title":"Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism","volume":"13","author":"Tominaga","year":"1997","journal-title":"Semin Surg Oncol"},{"key":"R4-24-20230601","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/sj.ki.5001594","article-title":"Basic and clinical aspects of parathyroid hyperplasia in chronic kidney disease","volume":"70","author":"Fukagawa","year":"2006","journal-title":"Kidney Int"},{"key":"R5-24-20230601","doi-asserted-by":"crossref","first-page":"840","DOI":"10.7326\/0003-4819-147-12-200712180-00004","article-title":"Meta-analysis: Vitamin D compounds in chronic kidney disease","volume":"147","author":"Palmer","year":"2007","journal-title":"Ann Intern Med"},{"key":"R6-24-20230601","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1172\/JCI116720","article-title":"Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients","volume":"92","author":"Fukuda","year":"1993","journal-title":"J Clin Invest"},{"key":"R7-24-20230601","first-page":"1598","article-title":"Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism","volume":"81","author":"Kifor","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-24-20230601","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ki.1997.41","article-title":"Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism","volume":"51","author":"Gogusev","year":"1997","journal-title":"Kidney Int"},{"key":"R9-24-20230601","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1111\/j.1523-1755.2000.00370.x","article-title":"Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism","volume":"58","author":"Yano","year":"2000","journal-title":"Kidney Int"},{"key":"R10-24-20230601","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/j.1523-1755.2002.kid585.x","article-title":"Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism","volume":"62","author":"Tokumoto","year":"2002","journal-title":"Kidney Int"},{"key":"R11-24-20230601","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000188261","article-title":"Serial evaluation of parathyroid size by ultrasonography is another useful marker for the long-term prognosis of calcitriol pulse therapy in chronic dialysis patient","volume":"68","author":"Fukagawa","year":"1994","journal-title":"Nephron"},{"key":"R12-24-20230601","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1093\/ndt\/gfg451","article-title":"Relationship between parathyroid gland size and responsiveness to maxacalcitol therapy in patients with secondary hyperparathyroidism","volume":"18","author":"Okuno","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"R13-24-20230601","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1744-9987.2006.00364.x","article-title":"Is the volume of the parathyroid gland a predictor of Maxacalcitol response in advanced secondary hyperparathyroidism?","volume":"10","author":"Tominaga","year":"2006","journal-title":"Ther Apher Dial"},{"key":"R14-24-20230601","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJM199008093230617","article-title":"Regression of parathyroid hyperplasia by calcitriol-pulse therapy in patients on long-term dialysis","volume":"323","author":"Fukagawa","year":"1990","journal-title":"N Engl J Med"},{"key":"R15-24-20230601","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/ki.1994.223","article-title":"Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD","volume":"45","author":"Quarles","year":"1994","journal-title":"Kidney Int"},{"key":"R16-24-20230601","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1681\/ASN.V1341017","article-title":"The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism","volume":"13","author":"Goodman","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R17-24-20230601","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.ASN.0000050224.03126.AD","article-title":"The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease","volume":"14","author":"Quarles","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R18-24-20230601","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJMoa031633","article-title":"Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis","volume":"350","author":"Block","year":"2004","journal-title":"N Engl J Med"},{"key":"R19-24-20230601","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1681\/ASN.2004060512","article-title":"Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: A randomized double-blind, multicenter study","volume":"16","author":"Lindberg","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R20-24-20230601","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ndt\/gfm534","article-title":"Cinacalcet (KRN1493) effectively decreases the serum intact PTH level with favorable control of the serum phosphorus and calcium levels in Japanese dialysis patients","volume":"23","author":"Fukagawa","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"R21-24-20230601","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1744-9987.2008.00631.x","article-title":"Impact of cinacalcet hydrochloride on the achievement of the Japanese Society for Dialysis Therapy (JSDT) guideline targets: A post-hoc analysis of the KRN1493 study","volume":"12","author":"Komaba","year":"2008","journal-title":"Ther Apher Dial"},{"key":"R22-24-20230601","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1093\/ndt\/gfn026","article-title":"Combined therapy with cinacalcet and low doses of vitamin D sterols in patients with moderate to severe secondary hyperparathyroidism","volume":"23","author":"Block","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"R23-24-20230601","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.2215\/CJN.01040308","article-title":"Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: The ACHIEVE study results","volume":"3","author":"Fishbane","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R24-24-20230601","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2215\/CJN.03591006","article-title":"The OPTIMA study: Assessing a new cinacalcet (Sensipar\/Mimpara) treatment algorithm for secondary hyperparathyroidism","volume":"3","author":"Messa","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R25-24-20230601","first-page":"iii49","article-title":"Association between long-term efficacy of cinacalcet and parathyroid gland volume in haemodialysis patients with secondary hyperparathyroidism","volume":"1","author":"Tanaka","year":"2008","journal-title":"NDT Plus"},{"key":"R26-24-20230601","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/ndt\/gfn654","article-title":"Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism","volume":"24","author":"Meola","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"R27-24-20230601","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1681\/ASN.V115903","article-title":"Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats","volume":"11","author":"Chin","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"R28-24-20230601","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/ndt\/gfm177","article-title":"Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies","volume":"22","author":"Drueke","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"R29-24-20230601","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/ndt\/gfn717","article-title":"Regression of parathyroid hyperplasia by calcimimetics\u2014fact or illusion?","volume":"24","author":"Komaba","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"R31-24-20230601","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/bmj.4.5893.643","article-title":"Interpretation of serum calcium levels in patients with abnormal serum proteins","volume":"4","author":"Payne","year":"1973","journal-title":"BMJ"},{"key":"R32-24-20230601","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00774-006-0687-y","article-title":"Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels","volume":"24","author":"Kawata","year":"2006","journal-title":"J Bone Miner Metab"},{"key":"R33-24-20230601","doi-asserted-by":"crossref","first-page":"F1390","DOI":"10.1152\/ajprenal.00262.2006","article-title":"The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands","volume":"292","author":"Rodriguez","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"R34-24-20230601","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1097\/01.ASN.0000141016.20133.33","article-title":"Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency","volume":"15","author":"Mizobuchi","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R35-24-20230601","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1172\/JCI119851","article-title":"The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor","volume":"100","author":"Wada","year":"1997","journal-title":"J Clin Invest"},{"key":"R36-24-20230601","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1523-1755.2005.67103.x","article-title":"Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism","volume":"67","author":"Colloton","year":"2005","journal-title":"Kidney Int"},{"key":"R37-24-20230601","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2215\/CJN.04150907","article-title":"Does vitamin D receptor and calcium receptor activation therapy play a role in the histopathologic alterations of parathyroid glands in refractory uremic hyperparathyroidism?","volume":"3","author":"Lomonte","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R38-24-20230601","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1523-1755.2005.00596.x","article-title":"Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism","volume":"68","author":"Cunningham","year":"2005","journal-title":"Kidney Int"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201012000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:40:09Z","timestamp":1786369209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201012000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.02110310","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}