{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:54:17Z","timestamp":1790207657137,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mrs. Chantal Caron"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Small donor and\/or kidney sizes relative to recipient size are associated with a higher risk of kidney allograft failure. Donor and recipient ages are associated with graft survival and may modulate the relationship between size mismatch and the latter. The aim of this study was to determine whether the association between donor-recipient size mismatch and graft survival differs by donor and recipient age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurement<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of first adult deceased donor kidney transplantations performed between 2000 and 2018 recorded in the Scientific Registry of Transplant Recipients. We used multivariable Cox proportional hazards models to assess the association between donor-recipient body surface area ratio and death-censored graft survival, defined as return to dialysis or retransplantation. We considered interactions between donor-recipient body surface area ratio and each of recipient and donor age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 136,321 kidney transplant recipients included in this study, 23,614 (17%) experienced death-censored graft loss over a median follow-up of 4.3 years (interquartile range, 1.9\u20137.8 years). The three-way donor-recipient body surface area ratio by donor age by recipient age interaction was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04). The magnitude of the association between severe size mismatch (donor-recipient body surface area ratio &lt;0.80 versus \u22651.00) and death-censored graft survival was stronger with older donor age and recipient age. In all recipient age categories except the youngest (18\u201330 years), 5- and 10-year graft survival rates were similar or better with a size-mismatched donor aged &lt;40 years than a nonsize-mismatched donor aged 40 years or older.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association of donor-recipient size mismatch on long-term graft survival is modulated by recipient and donor age. Size-mismatched kidneys yield excellent graft survival when the donor is young. Donor age was more strongly associated with graft survival than size mismatch.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.02310220","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T15:30:16Z","timestamp":1598369416000},"page":"1455-1463","source":"Crossref","is-referenced-by-count":27,"title":["Donor Age, Donor-Recipient Size Mismatch, and Kidney Graft Survival"],"prefix":"10.2215","volume":"15","author":[{"given":"Fanny","family":"Lepeytre","sequence":"first","affiliation":[{"name":"Immunopathology Division, Research Centre, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Delmas-Frenette","sequence":"additional","affiliation":[{"name":"Immunopathology Division, Research Centre, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation (CORE), McGill University Health Centre, Montr\u00e9al, Queb\u00e9c, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Larivi\u00e8re-Beaudoin","sequence":"additional","affiliation":[{"name":"Immunopathology Division, Research Centre, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-004X","authenticated-orcid":false,"given":"Ruth","family":"Sapir-Pichhadze","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation (CORE), McGill University Health Centre, Montr\u00e9al, Queb\u00e9c, Canada"},{"name":"Division of Nephrology and the Multi Organ Transplant Program, Royal Victoria Hospital, McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany J.","family":"Foster","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation (CORE), McGill University Health Centre, Montr\u00e9al, Queb\u00e9c, Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"Cardinal","sequence":"additional","affiliation":[{"name":"Immunopathology Division, Research Centre, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ki.1996.307","article-title":"A study of the quality of life and cost-utility of renal transplantation","volume":"50","author":"Laupacis","year":"1996","journal-title":"Kidney Int"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1681\/ASN.2013070784","article-title":"New national allocation policy for deceased donor kidneys in the United States and possible effect on patient 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Predicting survival after deceased donor kidney transplant by donor-recipient combination","volume":"19","author":"Bae","year":"2019","journal-title":"Am J Transplant"},{"key":"B34-20230813","first-page":"379","article-title":"Spurious correlation and the fallacy of the ratio standard revisited","volume":"56","author":"Kronmal","year":"1992","journal-title":"J R Stat Soc Ser A Stat Soc"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.02310220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:39:59Z","timestamp":1786369199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.02310220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.02310220","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]}}}