{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:27:56Z","timestamp":1791077276976,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.2215\/cjn.02730409","type":"journal-article","created":{"date-parts":[[2009,10,9]],"date-time":"2009-10-09T21:24:42Z","timestamp":1255123482000},"page":"1920-1924","source":"Crossref","is-referenced-by-count":171,"title":["Alternative Pathway of Complement in Children with Diarrhea-Associated Hemolytic Uremic Syndrome"],"prefix":"10.2215","volume":"4","author":[{"given":"Joshua M.","family":"Thurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Marians","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woodruff","family":"Emlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Akana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Michael","family":"Holers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Kline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Christen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Trachtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20230601","first-page":"1073","article-title":"Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome","volume":"365","author":"Tarr","year":"2005","journal-title":"Lancet"},{"key":"R2-10-20230601","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1097\/01.ASN.0000027873.85792.52","article-title":"Molecular basis for high renal cell sensitivity to the cytotoxic effects of Shigatoxin-1: Upregulation of globotriaosylceramide expression","volume":"13","author":"Hughes","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R3-10-20230601","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1203\/00006450-200212000-00019","article-title":"Circulating granulocyte colony-stimulating factor, C-X-C, and C-C chemokines with Escherichia coli O157:H7 associated with hemolytic uremic syndrome","volume":"52","author":"Proulx","year":"2002","journal-title":"Pediatr Res"},{"key":"R4-10-20230601","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/sj.ki.5001581","article-title":"A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders","volume":"70","author":"Besbas","year":"2006","journal-title":"Kidney Int"},{"key":"R5-10-20230601","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000187063","article-title":"Hypocomplementemia and leukocytosis in diarrhea-associated hemolytic uremic syndrome","volume":"62","author":"Robson","year":"1992","journal-title":"Nephron"},{"key":"R6-10-20230601","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/jama.290.10.1337","article-title":"Effect of a Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: A randomized controlled trial","volume":"290","author":"Trachtman","year":"2003","journal-title":"JAMA"},{"key":"R7-10-20230601","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s004670050187","article-title":"Management of patients with hemolytic uremic syndrome demonstrating severe azotemia but not oliguria","volume":"10","author":"Schulman","year":"1996","journal-title":"Pediatr Nephrol"},{"key":"R8-10-20230601","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1681\/ASN.V133699","article-title":"Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome","volume":"13","author":"Ray","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R9-10-20230601","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00467-006-0146-y","article-title":"Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: A novel marker of renal injury","volume":"21","author":"Trachtman","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"R10-10-20230601","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1006\/cyto.1999.0624","article-title":"Inflammatory and immunological parameters in children with haemolytic uremic syndrome(HUS) and gastroenteritis: Pathophysiological and diagnostic clues","volume":"12","author":"Westerholt","year":"2000","journal-title":"Cytokine"},{"key":"R11-10-20230601","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-065X.2008.00641.x","article-title":"The spectrum of complement alternative pathway-mediated diseases","volume":"223","author":"Holers","year":"2008","journal-title":"Immunol Rev"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-200912000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:41:36Z","timestamp":1786369296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-200912000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.02730409","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}