{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:24:10Z","timestamp":1790288650862,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    Paraproteins are monoclonal Igs or their components (light or heavy chains) that are produced by a clonal population of mature B cells, most commonly plasma cells. These paraproteins or monoclonal proteins are secreted into the blood and subsequently filtered by the glomerulus before entering into urine, where they can cause various types of kidney disease, including both glomerular and tubulointerstitial injuries. Furthermore, a monoclonal protein that causes a specific glomerular or tubulointerstitial lesion in a human can reproducibly cause the same pathology when injected into an animal, supporting unique paraprotein characteristics. This Moving Points in Nephrology will provide an update for the\n                    <jats:italic toggle=\"yes\">Clinical Journal of the American Society of Nephrology<\/jats:italic>\n                    readership on some of the clinically relevant kidney lesions associated with monoclonal paraprotein production and the pathophysiology underlying these kidney lesions.\n                  <\/jats:p>","DOI":"10.2215\/cjn.02960316","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T13:20:26Z","timestamp":1481116826000},"page":"2256-2259","source":"Crossref","is-referenced-by-count":11,"title":["Paraprotein\u2013Related Kidney Disease: Attack of the Killer M Proteins"],"prefix":"10.2215","volume":"11","author":[{"given":"Mark A.","family":"Perazella","sequence":"first","affiliation":[{"name":"Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Division of Nephrology, Veterans Affairs Connecticut, West Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, Section of Critical Care Nephrology, University of Texas Health Science Center at Houston Medical School, Houston, Texas; and"},{"name":"Section of Nephrology, University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the American Society of Nephrology Onco-Nephology Forum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.ackd.2013.09.002","article-title":"Cancer and the kidney: The growth of onco-nephrology","volume":"21","author":"Perazella","year":"2014","journal-title":"Adv Chronic Kidney Dis"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1200\/JCO.2014.56.5622","article-title":"Onco-nephrology: An invitation to a new field","volume":"32","author":"Finkel","year":"2014","journal-title":"J Clin Oncol"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2215\/CJN.03240312","article-title":"Onco-nephrology: What the nephrologist needs to know about cancer and the kidney","volume":"7","author":"Berns","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/j.ackd.2013.08.002","article-title":"Acute kidney injury in the cancer patient","volume":"21","author":"Campbell","year":"2014","journal-title":"Adv Chronic Kidney Dis"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrneph.2011.168","article-title":"The pathogenesis and diagnosis of acute kidney injury in multiple myeloma","volume":"8","author":"Hutchison","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/pgmj.2006.054627","article-title":"Management of paraproteinaemia","volume":"83","author":"Cook","year":"2007","journal-title":"Postgrad Med J"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1681\/ASN.2012040388","article-title":"Mechanisms of light chain injury along the tubular nephron","volume":"23","author":"Sanders","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00041552-199303000-00011","article-title":"Renal involvement in plasma cell dyscrasias","volume":"2","author":"Sanders","year":"1993","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.2215\/CJN.02980316","article-title":"Glomerular diseases associated with paraproteinemias","volume":"11","author":"Motwani","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.2215\/CJN.01640216","article-title":"Evaluation and treatment of myeloma cast nephropathy","volume":"11","author":"Finkel","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.2215\/CJN.02920316","article-title":"diagnosing and treating monoclonal gammopathy of renal significance","volume":"11","author":"Rosner","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.2215\/CJN.02560316","article-title":"on behalf of the American Society of Nephrology Onco-Nephrology Forum: Paraprotein\u2013related kidney disease: Kidney injury from paraproteins\u2014What determines the site of injury?","volume":"11","author":"Doshi","year":"2016","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201612000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:36:27Z","timestamp":1786368987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201612000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.02960316","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}