{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:45:31Z","timestamp":1786373131649,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Abnormally elevated GFR, or hyperfiltration, is a proposed mechanism for kidney injury in diabetes, prediabetes, and obesity. This study investigated whether lack of physical exercise is associated with hyperfiltration and whether exercise modifies the positive association between fasting glucose and measured GFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>The Renal Iohexol Clearance Survey in Troms\u00f8 6 measured GFR as single-sample plasma iohexol clearance in 1506 members of the general population (age 50\u201362 years) without diabetes, cardiovascular disease, or kidney disease. Leisure-time physical exercise was assessed by a self-administered questionnaire. Hyperfiltration was defined as GFR above the 90th percentile after adjustment for sex, age, weight, height, and use of renin-angiotensin system inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High-intensity exercise was associated with lower adjusted odds of hyperfiltration in men (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.28\u20130.80) but not in women (OR, 1.02; 95% CI, 0.60\u20131.72). In both sexes, high-intensity exercise modified the association between fasting glucose and GFR. A fasting glucose level 1 mmol\/L higher was associated with a GFR that was 7.3 (95% CI, 4.0\u201310.6) and 6.2 (95% CI, 3.4\u20139.0) ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      higher in men and women who never exercised or exercised with low intensity. There was no association between fasting glucose and GFR in men and women who exercised with high intensity (interaction,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High-intensity exercise was associated with lower odds of hyperfiltration in men and modified the association between glucose and GFR of both sexes in a population without diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.02980312","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T23:51:30Z","timestamp":1345765890000},"page":"1801-1810","source":"Crossref","is-referenced-by-count":42,"title":["Physical Exercise, Fasting Glucose, and Renal Hyperfiltration in the General Population"],"prefix":"10.2215","volume":"7","author":[{"given":"Toralf","family":"Melsom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla Dorte","family":"Mathisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Ann Winther","family":"Eilertsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole C.","family":"Ingebretsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond","family":"Jenssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit D.","family":"Solbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Toft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn O.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20230811","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10157-009-0156-8","article-title":"Report of the Asian Forum of Chronic Kidney Disease Initiative (AFCKDI) 2007. \u201cCurrent status and perspective of CKD in Asia\u201d: Diversity and specificity among Asian countries.","volume":"13","author":"Tsukamoto","year":"2009","journal-title":"Clin Exp Nephrol"},{"key":"R2-10-20230811","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/01.EDE.0000071413.55296.c4","article-title":"Lifestyle factors, obesity and the risk of chronic kidney disease.","volume":"14","author":"Stengel","year":"2003","journal-title":"Epidemiology"},{"key":"R3-10-20230811","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.atherosclerosis.2008.02.027","article-title":"Cardiovascular risk-factors predict progression of urinary albumin-excretion in a general, non-diabetic population: A gender-specific follow-up study.","volume":"201","author":"Solbu","year":"2008","journal-title":"Atherosclerosis"},{"key":"R4-10-20230811","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1001\/archinternmed.2009.438","article-title":"Physical activity and rapid decline in kidney function among older adults.","volume":"169","author":"Robinson-Cohen","year":"2009","journal-title":"Arch Intern Med"},{"key":"R5-10-20230811","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.ajkd.2005.11.027","article-title":"Obesity, smoking, and physical inactivity as risk factors for CKD: Are men more vulnerable?","volume":"47","author":"Hallan","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"R6-10-20230811","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/ki.1996.265","article-title":"The hyperfiltration theory: A paradigm shift in nephrology.","volume":"49","author":"Brenner","year":"1996","journal-title":"Kidney Int"},{"key":"R7-10-20230811","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00125-009-1268-0","article-title":"Is hyperfiltration associated with the future risk of developing diabetic nephropathy? 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