{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:42Z","timestamp":1786373082321,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK115562"],"award-info":[{"award-number":["R01-DK115562"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK106962"],"award-info":[{"award-number":["U01DK106962"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01-DK 093770"],"award-info":[{"award-number":["R01-DK 093770"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01-DK 113191"],"award-info":[{"award-number":["R01-DK 113191"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["U01DK079210"],"award-info":[{"award-number":["U01DK079210"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>In kidney transplantation, the relative contribution of donor versus other factors on clinical outcomes is unknown. We sought to quantify overall donor effects on transplant outcomes for kidney donations from deceased donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>For paired donations from deceased donors resulting in transplants to different recipients, the magnitude of donor effects can be quantified by examining the excess of concordant outcomes within kidney pairs beyond chance concordance. Using data from the Organ Procurement and Transplantation Network between the years 2013 and 2017, we examined concordance measures for delayed graft function, death-censored 1-year graft failure, and death-censored 3-year graft failure. The concordance measures were excess relative risk, excess absolute risk, and the fixation index (where zero is no concordance and one is perfect concordance). We further examined concordance in strata of kidneys with similar values of the Kidney Donor Profile Index, a common metric of organ quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>If the transplant of the kidney mate resulted in delayed graft function, risk for delayed graft function was 19% higher (95% confidence interval [95% CI], 18% to 20%), or 1.76-fold higher (95% CI, 1.73- to 1.80-fold), than baseline. If a kidney graft failed within 1 year, then the kidney mate\u2019s risk of failure was 6% higher (95% CI, 4% to 9%), or 2.85-fold higher (95% CI, 2.25- to 3.48-fold), than baseline. For 3-year graft failure, the excess absolute risk was 7% (95% CI, 4% to 10%) but excess relative risk was smaller, 1.91-fold (95% CI, 1.56- to 2.28-fold). Fixation indices were 0.25 for delayed graft function (95% CI, 0.24 to 0.27), 0.07 for 1-year graft failure (95% CI, 0.04 to 0.09), and 0.07 for 3-year graft failure (95% CI, 0.04 to 0.10). Results were similar in strata of kidneys with a similar Kidney Donor Profile Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall results indicated that the donor constitution has small or moderate effect on post-transplant clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.03810319","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T14:35:11Z","timestamp":1572618911000},"page":"1781-1787","source":"Crossref","is-referenced-by-count":10,"title":["Quantifying Donor Effects on Transplant Outcomes Using Kidney Pairs from Deceased Donors"],"prefix":"10.2215","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6438-9583","authenticated-orcid":false,"given":"Kathleen F.","family":"Kerr","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Morenz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-0514","authenticated-orcid":false,"given":"Heather","family":"Thiessen-Philbrook","sequence":"additional","affiliation":[{"name":"Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-9168","authenticated-orcid":false,"given":"Steven G.","family":"Coca","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-2412","authenticated-orcid":false,"given":"F. Perry","family":"Wilson","sequence":"additional","affiliation":[{"name":"Program of Applied Translational Research, Department of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-069X","authenticated-orcid":false,"given":"Peter P.","family":"Reese","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-7385","authenticated-orcid":false,"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/01.ASN.0000042164.03115.B8","article-title":"Donor tissue characteristics influence cadaver kidney transplant function and graft survival but not rejection.","volume":"14","author":"Gourishankar","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1681\/ASN.2008070715","article-title":"\u201cNature versus nurture\u201d study of deceased-donor pairs in kidney transplantation.","volume":"20","author":"Louvar","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/j.1600-6143.2009.02692.x","article-title":"Fate of the mate: The influence of delayed graft function in renal transplantation on the mate recipient.","volume":"9","author":"Johnson","year":"2009","journal-title":"Am J Transplant"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1432-2277.2012.01517.x","article-title":"Concordance of outcomes of pairs of kidneys transplanted into different recipients.","volume":"25","author":"Traynor","year":"2012","journal-title":"Transpl Int"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1469-1809.1949.tb02451.x","article-title":"The genetical structure of populations.","volume":"15","author":"Wright","year":"1951","journal-title":"Ann Eugen"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2307\/2406485","article-title":"Variance of gene frequencies.","volume":"23","author":"Cockerham","year":"1969","journal-title":"Evolution"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1469-1809.2006.00267.x","article-title":"The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: A cautionary note.","volume":"70","author":"Zou","year":"2006","journal-title":"Ann Hum Genet"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1098\/rsbl.2008.0244","article-title":"Evidence of disassortative mating in a Tanganyikan cichlid fish and its role in the maintenance of intrapopulation dimorphism.","volume":"4","author":"Takahashi","year":"2008","journal-title":"Biol Lett"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/clpt.2010.233","article-title":"Enrichment of clinical study populations.","volume":"88","author":"Temple","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/1740774517723588","article-title":"Evaluating biomarkers for prognostic enrichment of clinical trials.","volume":"14","author":"Kerr","year":"2017","journal-title":"Clin Trials"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMra1507080","article-title":"Improving the supply and quality of deceased-donor organs for transplantation.","volume":"378","author":"Tullius","year":"2018","journal-title":"N Engl J Med"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1681\/ASN.2015010023","article-title":"New solutions to reduce discard of kidneys donated for transplantation.","volume":"27","author":"Reese","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1097\/TP.0000000000001238","article-title":"Predictors of deceased donor kidney discard in the United States.","volume":"101","author":"Marrero","year":"2017","journal-title":"Transplantation"},{"key":"B15-20230813","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.kint.2018.02.016","article-title":"Factors leading to the discard of deceased donor kidneys in the United States.","volume":"94","author":"Mohan","year":"2018","journal-title":"Kidney Int"},{"key":"B16-20230813","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/TP.0000000000001539","article-title":"Diagnosing the decades-long rise in the deceased donor kidney discard rate in the United States.","volume":"101","author":"Stewart","year":"2017","journal-title":"Transplantation"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.03810319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:42:08Z","timestamp":1786369328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.03810319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.03810319","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,1]]}}}