{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:51Z","timestamp":1786373091105,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012331","name":"Flanders Innovation and Entrepreneurship","doi-asserted-by":"crossref","award":["IWT.150199"],"award-info":[{"award-number":["IWT.150199"]}],"id":[{"id":"10.13039\/100012331","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C32\/17\/049"],"award-info":[{"award-number":["C32\/17\/049"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["1143919N"],"award-info":[{"award-number":["1143919N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["1844019N"],"award-info":[{"award-number":["1844019N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["1842919N"],"award-info":[{"award-number":["1842919N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>In preclinical studies, ischemia-reperfusion injury and older donor age are associated with graft inflammation in the early phase after transplantation. In human kidney transplantation, impaired allograft function in the first days after transplantation is often adjudicated to donor- and procedure-related characteristics, such as donor age, donor type, and ischemia times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>In a cohort of 984 kidney recipients, 329 indication biopsies were performed within the first 14 days after transplantation. The histologic picture of these biopsies and its relationship with alloimmune risk factors and donor- and procedure-related characteristics were studied, as well as the association with graft failure. Multivariable Cox models were applied to quantify the cause-specific hazard ratios for early rejection and early inflammatory scores, adjusted for potential confounders. For quantification of hazard ratios of early events for death-censored graft failure, landmark analyses starting from day 15 were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Early indication biopsy specimens displayed microvascular inflammation score \u22652 in 30% and tubulointerstitial inflammation score \u22652 in 49%. Rejection was diagnosed in 186 of 329 (57%) biopsies and associated with the presence of pretransplant donor-specific HLA antibodies and the number of HLA mismatches, but not nonimmune risk factors in multivariable Cox proportional hazards analysis. In multivariable Cox proportional hazards analysis, delayed graft function, the graft dysfunction that prompted an early indication biopsy, HLA mismatches, and pretransplant donor-specific HLA antibodies were significantly associated with a higher risk for death-censored graft failure, whereas early acute rejection was not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Indication biopsies performed early after kidney transplantation display inflammatory changes related to alloimmune risk factors. Nonimmune risk factors for ischemia-reperfusion injury, such as cold and warm ischemia time, older donor age, and donor type, were not identified as strong risk factors for early inflammation after human kidney transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.04230320","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T01:10:15Z","timestamp":1597108215000},"page":"1484-1493","source":"Crossref","is-referenced-by-count":9,"title":["The Histological Picture of Indication Biopsies in the First 2 Weeks after Kidney Transplantation"],"prefix":"10.2215","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-9157","authenticated-orcid":false,"given":"Elisabet","family":"Van Loon","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Lerut","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Pathology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-4669","authenticated-orcid":false,"given":"Aleksandar","family":"Senev","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Coemans","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Public Health and Primary Care, Leuven Biostatistics and Statistical Bioinformatics Centre, Katholieke Universiteit Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethard","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Jochmans","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Sainz Barriga","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"De Vusser","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaryllis H.","family":"Van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sprangers","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Immunology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule","family":"Emonds","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Pathology, University Hospitals Leuven, Leuven, Belgium"},{"name":"Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-0792","authenticated-orcid":false,"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium"},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ki.2015.88","article-title":"Kidney donation after circulatory death (DCD): State of the art","volume":"88","author":"Summers","year":"2015","journal-title":"Kidney Int"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/ajt.13968","article-title":"Local expansion of donation after circulatory death 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