{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:50Z","timestamp":1792818950711,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Background and objectives<\/jats:title>\n Large studies on long-term kidney outcome in patients with anti-glomerular basement membrane (anti-GBM) GN are lacking. This study aimed to identify clinical and histopathologic parameters that predict kidney outcome in these patients.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n This retrospective analysis included a total of 123 patients with anti-GBM GN between 1986 and 2015 from six centers worldwide. Their kidney biopsy samples were classified according to the histopathologic classification for ANCA-associated GN. Clinical data such as details of treatment were retrieved from clinical records. The primary outcome parameter was the occurrence of ESRD. Kidney survival was analyzed using the log-rank test and Cox regression analyses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The 5-year kidney survival rate was 34%, with an improved rate observed among patients diagnosed after 2007 (\n P<\/jats:italic>\n =0.01). In patients with anti-GBM GN, histopathologic class and kidney survival were associated (\n P<\/jats:italic>\n <0.001). Only one of 15 patients with a focal class biopsy sample (\u226550% normal glomeruli) developed ESRD. Patients with a sclerotic class biopsy sample (\u226550% globally sclerotic glomeruli) and patients with 100% cellular crescents did not recover from dialysis dependency at presentation. In multivariable analysis, dialysis dependency at presentation (hazard ratio [HR], 3.17; 95% confidence interval [95% CI], 1.59 to 6.32), percentage of normal glomeruli (HR, 0.97; 95% CI, 0.95 to 0.99), and extent of interstitial infiltrate (HR, 2.02; 95% CI, 1.17 to 3.50) were predictors of ESRD during follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dialysis dependency, low percentage of normal glomeruli, and large extent of interstitial infiltrate are associated with poor kidney outcome in anti-GBM GN. Kidney outcome has improved during recent years; the success rate doubled after 2007.<\/jats:p>\n <\/jats:sec>\n \n Podcast<\/jats:title>\n This article contains a podcast at https:\/\/www.asn-online.org\/media\/podcast\/CJASN\/2017_11_21_CJASNPodcast_18_1_v.mp3<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.04290417","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T20:25:29Z","timestamp":1511295929000},"page":"63-72","source":"Crossref","is-referenced-by-count":90,"title":["Predicting Outcome in Patients with Anti-GBM Glomerulonephritis"],"prefix":"10.2215","volume":"13","author":[{"given":"Emma E.","family":"van Daalen","sequence":"first","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Charles","family":"Jennette","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"McAdoo","sequence":"additional","affiliation":[{"name":"Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Pusey","sequence":"additional","affiliation":[{"name":"Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Alba","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Poulton","sequence":"additional","affiliation":[{"name":"Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Wolterbeek","sequence":"additional","affiliation":[{"name":"Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Goldschmeding","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Alchi","sequence":"additional","affiliation":[{"name":"Renal Department, Royal Berkshire Hospital, Reading, Berkshire, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak R.","family":"de Zoysa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, North Shore Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beula","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Nephrology, North Shore Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan 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