{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:38:59Z","timestamp":1786498739974,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Sequential echocardiography is routinely performed in patients with ESRD listed for transplantation. The benefit of this labor- and time-intensive measure, however, remains unclear. Thus, this study elucidated the various obtained routine echocardiography parameters that best predicted mortality and graft survival after renal transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>This study investigated 553 first renal transplant recipients listed in the Austrian Dialysis and Transplant Registry between 1992 and 2011 who had echocardiographic analysis at transplantation and survived at least 1 year. Cox proportional hazards models with the purposeful selection algorithms for covariables were used to identify predictors of mortality and graft loss. A Fine and Gray model was used to evaluate cause-specific death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow-up of 7.14 years, 81 patients died, and 59 patients experienced graft loss after the first year. The Kaplan\u2013Meier analysis showed that 85% of patients with a left atrial diameter below the median of 53 mm were alive 10 years after transplantation, whereas only 70% of those patients with a left atrial diameter equal to or above the median had survived (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). In the multivariable model, left atrial diameter (per millimeter) independently predicted overall mortality (hazard ratio, 1.06; 95% confidence interval, 1.03 to 1.08;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and cause-specific cardiac death (hazard ratio, 1.04; 95% confidence interval, 1.00 to 1.08;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04). Functional graft loss was predicted by the right atrial diameter (hazard ratio, 1.04; 95% confidence interval, 1.02 to 1.07;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The left atrial diameter determined at transplantation predicted overall and cardiac mortality. Patients with widely enlarged left atria exhibit a considerably reduced life expectancy. It remains to be determined, however, whether renal transplantation is futile in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.04300413","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:03:12Z","timestamp":1378425792000},"page":"2100-2105","source":"Crossref","is-referenced-by-count":18,"title":["Left Atrial Diameter and Survival among Renal Allograft Recipients"],"prefix":"10.2215","volume":"8","author":[{"given":"Alexander","family":"Kainz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Goliasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Wiesbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Nesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Mascherbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Kramar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wilflingseder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Oberbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20230811","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/ndt\/16.8.1545","article-title":"Causes of death after renal transplantation.","volume":"16","author":"Briggs","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"R2-11-20230811","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ki.1989.192","article-title":"Impact of left ventricular hypertrophy on survival in end-stage renal disease.","volume":"36","author":"Silberberg","year":"1989","journal-title":"Kidney Int"},{"key":"R3-11-20230811","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"R4-11-20230811","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/j.ajkd.2009.12.033","article-title":"Association of left atrial volume with mortality among ESRD patients with left ventricular hypertrophy referred for kidney transplantation.","volume":"55","author":"Patel","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"R5-11-20230811","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med"},{"key":"R6-11-20230811","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.transproceed.2005.06.022","article-title":"Effects of successful renal transplantation on left ventricular mass.","volume":"37","author":"Montanaro","year":"2005","journal-title":"Transplant Proc"},{"key":"R7-11-20230811","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.transproceed.2004.12.201","article-title":"Cardiovascular effects of successful renal transplantation: A 30-month study on left ventricular morphology, systolic and diastolic functions.","volume":"37","author":"Dudziak","year":"2005","journal-title":"Transplant Proc"},{"key":"R8-11-20230811","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1681\/ASN.2005090955","article-title":"Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation.","volume":"17","author":"Heinze","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R10-11-20230811","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/HJH.0b013e3281fc975a","article-title":"2007 guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).","volume":"25","author":"Mancia","year":"2007","journal-title":"J Hypertens"},{"key":"R11-11-20230811","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk.","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"key":"R12-11-20230811","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1751-0473-3-17","article-title":"Purposeful selection of variables in logistic regression.","volume":"3","author":"Bursac","year":"2008","journal-title":"Source Code Biol Med"},{"key":"R13-11-20230811","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0169-2607(97)00043-6","article-title":"Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions.","volume":"54","author":"Heinzl","year":"1997","journal-title":"Comput Methods Programs Biomed"},{"key":"R14-11-20230811","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","article-title":"Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values.","volume":"53","author":"Levey","year":"2007","journal-title":"Clin Chem"},{"key":"R15-11-20230811","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2215\/CJN.00920805","article-title":"Incidence, predictors, and associated outcomes of atrial fibrillation after kidney transplantation.","volume":"1","author":"Lentine","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"R16-11-20230811","first-page":"783","article-title":"Serial echocardiographic changes in patients on hemodialysis: An evaluation of guideline implementation.","volume":"19","author":"Covic","year":"2006","journal-title":"J Nephrol"},{"key":"R17-11-20230811","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.amjcard.2008.11.061","article-title":"Risk stratification of mortality in patients with heart failure and left ventricular ejection fraction >35%.","volume":"103","author":"Cygankiewicz","year":"2009","journal-title":"Am J Cardiol"},{"key":"R18-11-20230811","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1097\/TP.0b013e31828dbbbe","article-title":"Do echocardiographic parameters predict mortality in patients with end-stage renal disease?","volume":"95","author":"Stallworthy","year":"2013","journal-title":"Transplantation"},{"key":"R19-11-20230811","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.transproceed.2011.05.006","article-title":"Contribution of anemia and hypertension to left ventricular hypertrophy during the initial 2 years after renal transplantation.","volume":"43","author":"Ibernon","year":"2011","journal-title":"Transplant Proc"},{"key":"R20-11-20230811","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0002-9149(01)01460-6","article-title":"M-mode echocardiographic predictors of six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study).","volume":"87","author":"Gardin","year":"2001","journal-title":"Am J Cardiol"},{"key":"R21-11-20230811","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00392-010-0222-y","article-title":"Assessment of left atrial volume: A focus on echocardiographic methods and clinical implications.","volume":"100","author":"Khoo","year":"2011","journal-title":"Clin Res Cardiol"},{"key":"R22-11-20230811","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1751-7133.2011.00275.x","article-title":"Worsening renal function and prognosis in pulmonary hypertension patients hospitalized for right heart failure.","volume":"18","author":"Mielniczuk","year":"2012","journal-title":"Congest Heart Fail"},{"key":"R23-11-20230811","doi-asserted-by":"crossref","first-page":"e33902","DOI":"10.1371\/journal.pone.0033902","article-title":"Clinical impact of atrial fibrillation in patients with pulmonary hypertension.","volume":"7","author":"Rottlaender","year":"2012","journal-title":"PLoS One"},{"key":"R24-11-20230811","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1432-2277.2012.01428.x","article-title":"Hemoglobin variability after renal transplantation is associated with mortality.","volume":"25","author":"Kainz","year":"2012","journal-title":"Transpl Int"},{"key":"R25-11-20230811","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.2215\/CJN.04660511","article-title":"Echocardiographic parameters are independently associated with rate of renal function decline and progression to dialysis in patients with chronic kidney disease.","volume":"6","author":"Chen","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R26-11-20230811","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2215\/CJN.01400308","article-title":"Renal transplantation is not associated with regression of left ventricular hypertrophy: A magnetic resonance study.","volume":"3","author":"Patel","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"R27-11-20230811","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0041-1345(02)03962-3","article-title":"Clinical and echocardiographic evaluation of renal allograft recipients in the first year after transplantation.","volume":"35","author":"Iqbal","year":"2003","journal-title":"Transplant Proc"},{"key":"R28-11-20230811","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/j.transproceed.2006.10.044","article-title":"Cardiac functional and morphologic changes of renal allograft recipients in the early posttransplant period.","volume":"38","author":"Iqbal","year":"2006","journal-title":"Transplant Proc"},{"key":"R29-11-20230811","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ahj.2005.04.031","article-title":"Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: The Strong Heart Study (SHS).","volume":"151","author":"Kizer","year":"2006","journal-title":"Am Heart J"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201312000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:37:13Z","timestamp":1786369033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201312000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.04300413","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}