{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:58Z","timestamp":1786373098071,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Relatively little is known about the long-term outcomes of different histologic types of primary glomerulonephritis in Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>From 1993 to 2006, 987 patients undergoing renal biopsy were studied, and 580 patients (mean age=44.4 years, male=58.5%) with the four most common forms of glomerulonephritis (membranous nephropathy, focal and segmental glomerulosclerosis, IgA nephropathy, and minimal change disease) were selected for analysis. Median follow-up period was 5.9 (interquartile range=5.7) years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The focal and segmental glomerulosclerosis group displayed the highest incidence of ESRD (25.8%) and the fastest decline of estimated GFR (4.6 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      per year). The IgA nephropathy group also had a higher rate of ESRD than the membranous nephropathy patients (19.2% versus 4.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). In contrast, the membranous nephropathy group exhibited an overall death rate similar to the focal and segmental glomerulosclerosis group (17.2% versus 14.4%) but higher than the IgA nephropathy and minimal change disease patients (4.6% and 3.7%, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). The most powerful predictor for ESRD was focal and segmental glomerulosclerosis, whereas the strongest predictor for all-cause mortality was membranous nephropathy with higher proteinuria. Protectors against ESRD included male sex and higher hemoglobin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most predictors for ESRD and overall mortality found in this ethnic Chinese cohort were similar to other studies. However, some risk factors linked with distinct glomerular pathologies displayed differential clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.04500511","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T01:54:42Z","timestamp":1342230882000},"page":"1401-1408","source":"Crossref","is-referenced-by-count":74,"title":["Clinical Outcomes and Predictors for ESRD and Mortality in Primary GN"],"prefix":"10.2215","volume":"7","author":[{"given":"Yu-Hsiang","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chung","family":"Lien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Chang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chou","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chin","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chih","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuei-Liong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun-Jun","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20230811","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1681\/ASN.V13suppl_1s37","article-title":"Maintenance dialysis population dynamics: Current trends and long-term implications.","volume":"13","author":"Lysaght","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R2-6-20230811","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/ndt\/17.12.2071","article-title":"ESRD patients in 2001: Global overview of patients, treatment modalities and development trends.","volume":"17","author":"Moeller","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"R3-6-20230811","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1046\/j.1523-1755.2000.07407.x","article-title":"Epidemiology of end-stage renal disease: International comparisons of dialysis.","volume":"57","author":"Francesco","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"R4-6-20230811","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1523-1755.2004.00833.x","article-title":"Clinicopathologic correlations of renal pathology in Spain.","volume":"66","author":"Rivera","year":"2004","journal-title":"Kidney Int"},{"key":"R5-6-20230811","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0272-6386(12)70293-7","article-title":"Influence of clinical and histological features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy, and membranoproliferative glomerulonephritis: Survey of the recent literature.","volume":"20","author":"D\u2019Amico","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"R6-6-20230811","first-page":"211","article-title":"Diagnosis and treatment of primary glomerular diseases. 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