{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:03:51Z","timestamp":1793315031053,"version":"4.5.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Left ventricular assist devices (LVADs) are common and implantation carries risk of AKI. LVADs are used as a bridge to heart transplantation or as destination therapy. Patients with refractory heart failure that develop chronic cardiorenal syndrome and CKD often improve after LVAD placement. Nevertheless, reversibility of CKD is hard to predict. After LVAD placement, significant GFR increases may be followed by a late return to near baseline GFR levels, and in some patients, a decline in GFR. In this review, we discuss changes in GFR after LVAD placement, the incidence of AKI and associated mortality after LVAD placement, the management of AKI requiring RRT, and lastly, we review salient features about cardiorenal syndrome learned from the LVAD experience. In light of the growing number of patients using LVADs as a destination therapy, it is important to understand the effect of these devices on the kidney. Additional research and long-term data are required to better understand the relationship between the LVAD and the kidney.<\/jats:p>","DOI":"10.2215\/cjn.04670417","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T20:20:15Z","timestamp":1508962815000},"page":"348-355","source":"Crossref","is-referenced-by-count":63,"title":["Left Ventricular Assist Devices and the Kidney"],"prefix":"10.2215","volume":"13","author":[{"given":"Daniel W.","family":"Ross","sequence":"first","affiliation":[{"name":"Division of Kidney Diseases and Hypertension, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerin R.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimda","family":"Wanchoo","sequence":"additional","affiliation":[{"name":"Division of Kidney Diseases and Hypertension, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Majure","sequence":"additional","affiliation":[{"name":"Department of Cardiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Jauhar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold A.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Hofstra Northwell School of Medicine, Northwell Health, North Shore University Hospital, Manhasset, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massini","family":"Merzkani","sequence":"additional","affiliation":[{"name":"Division of Kidney Diseases and Hypertension, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenar 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