{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:42:45Z","timestamp":1786372965560,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"abstract":"Summary<\/jats:title>\n \n Background and objectives<\/jats:title>\n Kidney re-transplantation (KRT) candidates are considered at high risk for graft failure. Most of these patients are kept on a chronic steroid maintenance (CSM) regimen. The safety of early steroid withdrawal (ESW) remains unanswered in KRT.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n This study was aimed at comparing the outcomes of ESW and CSM in KRT. Retrospective analysis of 113 KRT patients (ESW,\n n<\/jats:italic>\n = 59; CSM,\n n<\/jats:italic>\n = 54) was performed. All patients received rabbit anti-thymocyte globulin\/steroid induction and were maintained on mycophenolate\/tacrolimus (\u00b1steroids).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One- and 5-year patient survival for the ESW and the CSM group were not significantly different (98\n versus<\/jats:italic>\n 96% and 91\n versus<\/jats:italic>\n 88%, respectively;\n P<\/jats:italic>\n = 0.991). No significant difference was seen in the graft survival for both groups at 1 and 5 years (98\n versus<\/jats:italic>\n 93% and 80\n versus<\/jats:italic>\n 74%, respectively;\n P<\/jats:italic>\n = 0.779). Mean 1- and 5-year estimated GFR was not statistically different between the groups (\n P<\/jats:italic>\n = 0.773 and 0.790, respectively). The incidence of acute rejection at 1 year was 17 and 22% in ESW and CSM patients, respectively (\n P<\/jats:italic>\n = 0.635). Compared with the ESW group, patients in the CSM group were more likely to be hyperlipidemic (\n P<\/jats:italic>\n = 0.044), osteoporotic (\n P<\/jats:italic>\n = 0.010), post-transplant diabetics (\n P<\/jats:italic>\n = 0.051) and required more medications to control BP (\n P<\/jats:italic>\n = 0.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ESW seems to be a reasonable approach in KRT recipients because the short and intermediate patient survival, graft survival, and graft function is comparable to CSM immunosuppression.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.05110610","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T22:57:26Z","timestamp":1288911446000},"page":"404-411","source":"Crossref","is-referenced-by-count":16,"title":["Early Steroid Withdrawal in Repeat Kidney Transplantation"],"prefix":"10.2215","volume":"6","author":[{"given":"Muhammad 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