{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:57:54Z","timestamp":1792205874931,"version":"4.4.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Background and objectives<\/jats:title>\n For many women pregnancy is the first contact with health services, thus providing an opportunity to identify renal disease. This study compares causes and long-term renal outcomes of biopsy-proven renal disease identified during pregnancy or within 1 year postpartum, with nonpregnant women.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n Native renal biopsies (1997\u20132012), in women of childbearing age (16 to <50 years), from 21 hospitals were studied. The pregnancy-related diagnosis group included those women with abnormal urinalysis\/raised creatinine identified during pregnancy or within 1 year postpartum. Pregnancy-related and control biopsies were matched for age and ethnicity (black versus nonblack).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and seventy-three pregnancy-related biopsies (19 antenatal, 154 postpregnancy) were identified and matched with 1000 controls. FSGS was more common in pregnancy-related biopsies (32.4%) than controls (9.7%) (\n P<\/jats:italic>\n <0.001) but there were no differences in Columbia classification. Women with a pregnancy-related diagnosis were younger (32.1 versus 34.2 years;\n P<\/jats:italic>\n =0.004) and more likely to be black (26.0% versus 13.3%;\n P<\/jats:italic>\n <0.001) than controls, although there were no differences in ethnicities in women with FSGS. The pregnancy-related group (excluding antenatal biopsies) was more likely to have a decline in Chronic Kidney Disease Epidemiology Collaboration eGFR in the follow-up period than the control group (odds ratio, 1.67; 95% confidence interval, 1.03 to 2.71;\n P<\/jats:italic>\n =0.04), and this decline appeared to be more rapid (\u22121.33 versus \u22120.56 ml\/min per 1.73 m\n 2<\/jats:sup>\n per year, respectively;\n P<\/jats:italic>\n =0.045). However, there were no differences between groups in those who required RRT or who died.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Pregnancy is an opportunity to detect kidney disease. FSGS is more common in women who have been pregnant than in controls, and disease identified in pregnancy or within 1 year postpartum is more likely to show a subsequent decline in renal function. Further work is required to determine whether pregnancy initiates, exacerbates, or reveals renal disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.05610516","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T22:21:54Z","timestamp":1481322114000},"page":"408-416","source":"Crossref","is-referenced-by-count":23,"title":["A Multicenter Cohort Study of Histologic Findings and Long-Term Outcomes of Kidney Disease in Women Who Have Been Pregnant"],"prefix":"10.2215","volume":"12","author":[{"given":"Philip","family":"Webster","sequence":"first","affiliation":[{"name":"Imperial College Renal and Transplant Centre, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom;"},{"name":"Department of Medicine, Imperial College London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Webster","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Women\u2019s Health Academic Centre, King\u2019s College London and King\u2019s Health Partners, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Terence","family":"Cook","sequence":"additional","affiliation":[{"name":"Imperial College Renal and Transplant Centre, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom;"},{"name":"Department of Medicine, Imperial College London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Horsfield","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Guy\u2019s and St. Thomas\u2019 National Health Service Foundation Trust, London, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Seed","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Women\u2019s Health Academic Centre, King\u2019s College London and King\u2019s Health Partners, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vaz","sequence":"additional","affiliation":[{"name":"Imperial College Renal and Transplant Centre, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Santos","sequence":"additional","affiliation":[{"name":"Imperial College Renal and Transplant Centre, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lydon","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Women\u2019s Health Academic Centre, King\u2019s College London and King\u2019s Health Partners, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Homsy","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Women\u2019s Health Academic Centre, King\u2019s College London and King\u2019s Health Partners, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Lightstone","sequence":"additional","affiliation":[{"name":"Imperial College Renal and Transplant Centre, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom;"},{"name":"Department of Medicine, Imperial College London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Bramham","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Women\u2019s Health Academic Centre, King\u2019s College London and King\u2019s Health Partners, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2015.230","article-title":"A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010.","volume":"88","author":"Mills","year":"2015","journal-title":"Kidney Int"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate.","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0030-1268712","article-title":"Performance of estimated glomerular filtration rate prediction equations in preeclamptic patients.","volume":"28","author":"Alper","year":"2011","journal-title":"Am J 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Transplant"},{"key":"B17-20230813","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ndt\/gfl711","article-title":"Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.","volume":"22","author":"Garovic","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"B18-20230813","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1177\/1933719109338630","article-title":"Decreased nephrin and GLEPP-1, but increased VEGF, Flt-1, and nitrotyrosine, expressions in kidney tissue sections from women with preeclampsia.","volume":"16","author":"Zhao","year":"2009","journal-title":"Reprod Sci"},{"key":"B19-20230813","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000046097","article-title":"Urinary podocytes in primary focal segmental 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meta-analysis.","volume":"345","author":"Morris","year":"2012","journal-title":"BMJ"},{"key":"B32-20230813","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0002-9378(11)91692-5","article-title":"Natural history of chronic proteinuria complicating pregnancy.","volume":"167","author":"Stettler","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"B33-20230813","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/1471-0528.12111","article-title":"Kidney biopsy in pregnancy: Evidence for counselling? 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