{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:33:24Z","timestamp":1791423204737,"version":"4.3.3"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U24DK100845"],"award-info":[{"award-number":["U24DK100845"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK100846"],"award-info":[{"award-number":["U01DK100846"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK100876"],"award-info":[{"award-number":["U01DK100876"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK100866"],"award-info":[{"award-number":["U01DK100866"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK100867"],"award-info":[{"award-number":["U01DK100867"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007519","name":"NephCure Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Infections contribute to patient morbidity and mortality in glomerular disease. We sought to describe the incidence of, and identify risk factors for, infection-related acute care events among Cure Glomerulonephropathy Network (CureGN) study participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>CureGN is a prospective, multicenter, cohort study of children and adults with biopsy sample\u2013proven minimal change disease, FSGS, membranous nephropathy, or IgA nephropathy\/vasculitis. Risk factors for time to first infection-related acute care events (hospitalization or emergency department visit) were identified using multivariable Cox proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1741 participants (43% female, 41% &lt;18 years, 68% White), 163 (9%) experienced infection-related acute care events over a median follow-up of 17 months (interquartile range, 9\u201326 months). Unadjusted incidence rates of infection-related acute care events were 13.2 and 6.2 events per 100 person-years among pediatric and adult participants, respectively. Among participants with versus without corticosteroid exposure at enrollment, unadjusted incidence rates were 50.6 and 28.6 per 100 person-years, respectively, during the first year of follow-up (adjusted hazard ratio for time to first infection, 1.31; 95% CI, 0.89 to 1.93), and 4.1 and 1.1 per 100 person-years, respectively, after 1 year of follow-up (hazard ratio, 2.99; 95% CI, 1.54 to 5.79). Hypoalbuminemia combined with nephrotic-range proteinuria (serum albumin \u22642.5 g\/dl and urinary protein-creatinine ratio &gt;3.5 mg\/mg), compared with serum albumin &gt;2.5 g\/dl and urinary protein-creatinine ratio \u22643.5 mg\/mg, was associated with higher risk of time to first infection (adjusted hazard ratio, 2.49; 95% CI, 1.51 to 4.12).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among CureGN participants, infection-related acute care events were common and associated with younger age, corticosteroid exposure, and hypoalbuminemia with proteinuria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.05900420","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T19:25:14Z","timestamp":1603221914000},"page":"1749-1761","source":"Crossref","is-referenced-by-count":28,"title":["Infection-Related Acute Care Events among Patients with Glomerular Disease"],"prefix":"10.2215","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-3037","authenticated-orcid":false,"given":"Dorey A.","family":"Glenn","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace D.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-1308","authenticated-orcid":false,"given":"Michelle","family":"O\u2019Shaughnessy","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Cork University Hospital Group, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bomback","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisha","family":"Gibson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-021X","authenticated-orcid":false,"given":"Larry A.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8357","authenticated-orcid":false,"given":"Susan","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Mottl","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the CureGN Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.ajkd.2009.04.005","article-title":"CKD and risk of hospitalization and death with pneumonia","volume":"54","author":"James","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1053\/j.ajkd.2016.09.018","article-title":"CKD and risk for hospitalization with infection: The Atherosclerosis Risk in Communities (ARIC) 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