{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:42:59Z","timestamp":1786372979408,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Premature cardiovascular (CV) events, especially sudden cardiac death, are common in ESRD patients and associated with uremic cardiomyopathy. Identification of high-risk patients is difficult. Microvolt T-wave alternans (MTWA) is a noninvasive method of detecting variability in electrocardiogram (ECG) T-wave morphology and is a promising technique for identifying patients at high risk of ventricular tachyarrhythmias. MTWA results of ESRD and hypertensive left ventricular hypertrophy (LVH) patients were assessed to determine the prevalence of abnormal results and associations with uremic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>In this single-center observational study, 200 ESRD and 30 LVH patients underwent assessment including CV history, ECG, cardiac magnetic resonance imaging, and an MTWA exercise test. MTWA results were classified as \u201cnegative\u201d or \u201cabnormal\u201d on the basis of previously published reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An abnormal MTWA result was more common in ESRD compared with LVH patients (57.5%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      26.7%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). In ESRD patients, MTWA was significantly associated with uremic cardiomyopathy, clinical history of atherosclerosis (coronary, cerebral, peripheral) and diabetes mellitus, older age, and hemodialysis therapy. Independent associations with an abnormal MTWA result were older age, macrovascular disease, increased left ventricle (LV) mass, and LV dilation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Features of uremic cardiomyopathy are associated with an abnormal MTWA result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.06370710","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:50:00Z","timestamp":1290127800000},"page":"519-527","source":"Crossref","is-referenced-by-count":20,"title":["Microvolt T-Wave Alternans in End-Stage Renal Disease Patients\u2014Associations with Uremic Cardiomyopathy"],"prefix":"10.2215","volume":"6","author":[{"given":"Rajan K.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick B.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crawford","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Steedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Dargie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Cobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Jardine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-10-20230811","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ndt\/11.7.1277","article-title":"Outcome and risk factors for left ventricular disorders in chronic uraemia","volume":"11","author":"Parfrey","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"R3-10-20230811","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1093\/ndt\/gfn038","article-title":"Cause-specific mortality of dialysis patients after coronary revascularization: Why don't dialysis patients have better survival after coronary intervention?","volume":"23","author":"Herzog","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"R4-10-20230811","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1046\/j.1523-1755.1999.00391.x","article-title":"Sudden and cardiac death rates in hemodialysis patients","volume":"55","author":"Bleyer","year":"1999","journal-title":"Kidney Int"},{"key":"R5-10-20230811","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.HYP.0000022063.50739.60","article-title":"Norepinephrine and concentric hypertrophy in patients with end-stage renal disease","volume":"40","author":"Zoccali","year":"2002","journal-title":"Hypertension"},{"key":"R6-10-20230811","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1053\/j.ajkd.2005.04.006","article-title":"Mild hyperphosphatemia and mortality in hemodialysis patients","volume":"46","author":"Rodriguez-Benot","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"R7-10-20230811","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1440-1797.2006.00541.x","article-title":"Inflammation in end-stage renal disease: The hidden enemy","volume":"11","author":"Stenvinkel","year":"2006","journal-title":"Nephrology (Carlton"},{"key":"R8-10-20230811","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa0810177","article-title":"Rosuvastatin and cardiovascular events in patients undergoing hemodialysis","volume":"360","author":"Fellstrom","year":"2009","journal-title":"N Engl J Med"},{"key":"R9-10-20230811","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0735-1097(03)00241-9","article-title":"Carvedilol increases two-year survival in dialysis patients with dilated cardiomyopathy: A prospective, placebo-controlled trial","volume":"41","author":"Cice","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R10-10-20230811","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/sj.ki.5001657","article-title":"Prevention of cardiovascular events in end-stage renal disease: Results of a randomized trial of fosinopril and implications for future studies","volume":"70","author":"Zannad","year":"2006","journal-title":"Kidney Int"},{"key":"R11-10-20230811","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0002-9149(97)00694-2","article-title":"Electrical alternans during rest and exercise as predictors of vulnerability to ventricular arrhythmias","volume":"80","author":"Estes","year":"1997","journal-title":"Am J Cardiol"},{"key":"R12-10-20230811","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.hrthm.2005.07.020","article-title":"How to analyze T-wave alternans","volume":"2","author":"Richter","year":"2005","journal-title":"Heart Rhythm"},{"key":"R13-10-20230811","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1046\/j.1540-8167.2002.00502.x","article-title":"Interpretation and classification of microvolt T wave alternans tests","volume":"13","author":"Bloomfield","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"R14-10-20230811","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jacc.2005.11.026","article-title":"Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction","volume":"47","author":"Bloomfield","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R15-10-20230811","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jacc.2005.03.059","article-title":"Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: A meta-analysis","volume":"46","author":"Gehi","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R16-10-20230811","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1542-474X.2004.93543.x","article-title":"Microvolt T-wave alternans as predictor of electrophysiological testing results in professional competitive athletes","volume":"9","author":"Furlanello","year":"2004","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"R17-10-20230811","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.jacc.2005.11.079","article-title":"Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy","volume":"47","author":"Chow","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R18-10-20230811","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.1540-8159.2007.00849.x","article-title":"Relationship between abnormal microvolt T-wave alternans and poor glycemic control in type 2 diabetic patients","volume":"30","author":"Molon","year":"2007","journal-title":"Pacing Clin Electrophysiol"},{"key":"R20-10-20230811","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1475-097X.2004.00583.x","article-title":"Determinants of hypertension and left ventricular function in end stage renal failure: A pilot study using cardiovascular magnetic resonance imaging","volume":"24","author":"Stewart","year":"2004","journal-title":"Clin Physiol Funct Imaging"},{"key":"R21-10-20230811","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jmri.10262","article-title":"Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences","volume":"17","author":"Alfakih","year":"2003","journal-title":"J Magn Reson Imaging"},{"key":"R22-10-20230811","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.jacc.2007.09.004","article-title":"Prognostic value of T-wave alternans in patients with heart failure due to nonischemic cardiomyopathy: Results of the ALPHA Study","volume":"50","author":"Salerno-Uriarte","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"R23-10-20230811","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1161\/CIRCULATIONAHA.106.177276","article-title":"Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: A scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology","volume":"114","author":"Kern","year":"2006","journal-title":"Circulation"},{"key":"R24-10-20230811","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/ndt\/gfh611","article-title":"Atherosclerosis and vascular calcification are independent predictors of left ventricular hypertrophy in chronic haemodialysis patients","volume":"20","author":"Yildiz","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R25-10-20230811","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0085-2538(15)50904-6","article-title":"Survival of dialysis patients after cardiac arrest and the impact of implantable cardioverter defibrillators","volume":"68","author":"Herzog","year":"2005","journal-title":"Kidney Int"},{"key":"R26-10-20230811","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.hrthm.2006.06.013","article-title":"Renal dialysis as a risk factor for appropriate therapies and mortality in implantable cardioverter-defibrillator recipients","volume":"3","author":"Robin","year":"2006","journal-title":"Heart Rhythm"},{"key":"R27-10-20230811","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jacc.2008.08.018","article-title":"Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial Infarction Patients) trial","volume":"52","author":"Chow","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R28-10-20230811","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1161\/CIRCULATIONAHA.107.748962","article-title":"Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: Primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy","volume":"118","author":"Gold","year":"2008","journal-title":"Circulation"},{"key":"R29-10-20230811","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1038\/sj.jhh.1001254","article-title":"Microvolt T wave alternans in patients with hypertension and left ventricular hypertrophy","volume":"15","author":"Francis","year":"2001","journal-title":"J Hum Hypertens"},{"key":"R30-10-20230811","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2215\/CJN.02020408","article-title":"Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis","volume":"4","author":"Krane","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"R31-10-20230811","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1161\/01.CIR.99.10.1385","article-title":"Mechanism linking T-wave alternans to the genesis of cardiac fibrillation","volume":"99","author":"Pastore","year":"1999","journal-title":"Circulation"},{"key":"R32-10-20230811","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/S0735-1097(01)01597-2","article-title":"Life-threatening ventricular arrhythmias due to transient or correctable causes: High risk for death in follow-up","volume":"38","author":"Wyse","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"R34-10-20230811","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/ndt\/gfi005","article-title":"Dobutamine stress echocardiography and the resting but not exercise electrocardiograph predict severe coronary artery disease in renal transplant candidates","volume":"20","author":"Sharma","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R35-10-20230811","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jacc.2006.06.044","article-title":"\u201cIndeterminate\u201d microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction","volume":"48","author":"Kaufman","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"R36-10-20230811","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ahj.2006.12.021","article-title":"Prognostic implication of redefining indeterminate microvolt T-wave alternans studies as abnormal or normal","volume":"153","author":"Chan","year":"2007","journal-title":"Am Heart J"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201103000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:40:27Z","timestamp":1786369227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201103000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.06370710","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}