{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:53Z","timestamp":1786373093116,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["K01DK101677"],"award-info":[{"award-number":["K01DK101677"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["K24DK101828"],"award-info":[{"award-number":["K24DK101828"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["F30DK116658"],"award-info":[{"award-number":["F30DK116658"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>In the United States, kidney paired donation networks have facilitated an increasing proportion of kidney transplants annually, but transplant outcome differences beyond 5 years between paired donation and other living donor kidney transplant recipients have not been well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      Using registry-linked data, we compared National Kidney Registry (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =2363) recipients to control kidney transplant recipients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =54,497) (February 2008 to December 2017). We estimated the risk of death-censored graft failure and mortality using inverse probability of treatment weighted Cox regression. The parsimonious model adjusted for recipient factors (age, sex, black, race, body mass index \u226530 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , diabetes, previous transplant, preemptive transplant, public insurance, hepatitis C, eGFR, antibody depleting induction therapy, year of transplant), donor factors (age, sex, Hispanic ethnicity, body mass index \u226530 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and transplant factors (zero HLA mismatch).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      National Kidney Registry recipients were more likely to be women, black, older, on public insurance, have panel reactive antibodies &gt;80%, spend longer on dialysis, and be previous transplant recipients. National Kidney Registry recipients were followed for a median 3.7 years (interquartile range, 2.1\u20135.6; maximum 10.9 years). National Kidney Registry recipients had similar graft failure (5% versus 6%; log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.2) and mortality (9% versus 10%; log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.4) incidence compared with controls during follow-up. After adjustment for donor, recipient, and transplant factors, there no detectable difference in graft failure (adjusted hazard ratio, 0.95; 95% confidence interval, 0.77 to 1.18;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.6) or mortality (adjusted hazard ratio, 0.86; 95% confidence interval, 0.70 to 1.07;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.2) between National Kidney Registry and control recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even after transplanting patients with greater risk factors for worse post-transplant outcomes, nationalized paired donation results in equivalent outcomes when compared with control living donor kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.06660619","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T19:25:13Z","timestamp":1580239513000},"page":"228-237","source":"Crossref","is-referenced-by-count":33,"title":["Patient and Kidney Allograft Survival with National Kidney Paired Donation"],"prefix":"10.2215","volume":"15","author":[{"given":"David B.","family":"Leeser","sequence":"first","affiliation":[{"name":"Department of Surgery, East Carolina University, Greenville, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-8192","authenticated-orcid":false,"given":"Alvin G.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Surgery and"},{"name":"Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0150-4043","authenticated-orcid":false,"given":"Ashton A.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Surgery and"},{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Veale","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Massie","sequence":"additional","affiliation":[{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-9638","authenticated-orcid":false,"given":"Matthew","family":"Cooper","sequence":"additional","affiliation":[{"name":"Medstar Georgetown Transplant Institute, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cornell University, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Turgeon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dell School of Medicine, University of Texas at Austin, Austin, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4849","authenticated-orcid":false,"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery and"},{"name":"Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy D.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of California, Los Angeles, Los Angeles, California;"},{"name":"Terasaki Research Institute, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Flechner","sequence":"additional","affiliation":[{"name":"Department of Urology, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"issue":"Suppl 1","key":"B2-20230813","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/ajt.14557","article-title":"OPTN\/SRTR 2016 annual data report: Kidney.","volume":"18","author":"Hart","year":"2018","journal-title":"Am J Transplant"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1111\/j.1600-6143.2012.04156.x","article-title":"Chain transplantation: Initial experience of a large multicenter program.","volume":"12","author":"Melcher","year":"2012","journal-title":"Am J Transplant"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1600-6143.2010.03386.x","article-title":"Transporting live donor kidneys for kidney paired donation: Initial national results.","volume":"11","author":"Segev","year":"2011","journal-title":"Am J Transplant"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1111\/j.1600-6143.2012.04070.x","article-title":"Single-center kidney paired donation: The Methodist San Antonio experience.","volume":"12","author":"Bingaman","year":"2012","journal-title":"Am J Transplant"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/ajt.14597","article-title":"Shipping living donor kidneys and transplant recipient outcomes.","volume":"18","author":"Treat","year":"2018","journal-title":"Am J Transplant"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1111\/ajt.14744","article-title":"The first 9 years of kidney paired donation through the National Kidney Registry: Characteristics of donors and recipients compared with National Live Donor Transplant Registries.","volume":"18","author":"Flechner","year":"2018","journal-title":"Am J Transplant"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/ajt.14689","article-title":"Kidney exchange match rates in a large multicenter clearinghouse.","volume":"18","author":"Holscher","year":"2018","journal-title":"Am J Transplant"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/ajt.12777","article-title":"Big data in organ transplantation: Registries and administrative claims.","volume":"14","author":"Massie","year":"2014","journal-title":"Am J Transplant"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.6607","article-title":"Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies.","volume":"34","author":"Austin","year":"2015","journal-title":"Stat Med"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"702","DOI":"10.7326\/M17-2451","article-title":"The drug overdose epidemic and deceased-donor transplantation in the United States: A National Registry Study.","volume":"168","author":"Durand","year":"2018","journal-title":"Ann Intern Med"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0140-6736(14)62484-3","article-title":"Living kidney donation: Outcomes, ethics, and uncertainty.","volume":"385","author":"Reese","year":"2015","journal-title":"Lancet"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1111\/ajt.15046","article-title":"Temporal changes in the composition of a large multicenter kidney exchange clearinghouse: Do the hard-to-match accumulate?","volume":"18","author":"Holscher","year":"2018","journal-title":"Am J Transplant"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.06660619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:42:15Z","timestamp":1786369335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.06660619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.06660619","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]}}}