{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:40:09Z","timestamp":1786372809698,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>CKD is characterized by remarkably high hospitalization and readmission rates. Our study aim was to test a medication therapy management intervention to reduce subsequent acute care utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>The CKD Medication Intervention Trial was a single-blind (investigators), randomized clinical trial conducted at Providence Health Care in Spokane, Washington. Patients with CKD stages 3\u20135 not treated by dialysis who were hospitalized for acute illness were recruited. The intervention was designed to improve posthospitalization care by medication therapy management. A pharmacist delivered the intervention as a single home visit within 7 days of discharge. The intervention included these fundamental elements: comprehensive medication review, medication action plan, and a personal medication list. The primary outcome was a composite of acute care utilization (hospital readmissions and emergency department and urgent care visits) for 90 days after hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics of participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =141) included the following: age, 69\u00b111 (mean\u00b1SD) years old\u037e women, 48% (67 of 141)\u037e diabetes, 56% (79 of 141)\u037e hypertension, 83% (117 of 141)\u037e eGFR, 41\u00b114 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      (serum creatinine\u2013based Chronic Kidney Disease Epidemiology Collaboration equation)\u037e and urine albumin-to-creatinine ratio median, 43 mg\/g (interquartile range, 8\u2013528) creatinine. The most common primary diagnoses for hospitalization were the following: cardiovascular events, 36% (51 of 141); infections, 18% (26 of 141); and kidney diseases, 12% (17 of 141). The primary outcome occurred in 32 of 72 (44%) of the medication intervention group and 28 of 69 (41%) of those in usual care (log rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.72). For only hospital readmission, the rate was 19 of 72 (26%) in the medication intervention group and 18 of 69 (26%) in the usual care group (log rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.95). There was no between-group difference in achievement of guideline-based goals for use of renin-angiotensin system inhibition or for BP, hemoglobin, phosphorus, or parathyroid hormone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute care utilization after hospitalization was not reduced by a pharmacist-led medication therapy management intervention at the transition from hospital to home.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.06790617","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T20:20:28Z","timestamp":1514924428000},"page":"231-241","source":"Crossref","is-referenced-by-count":44,"title":["Medication Therapy Management after Hospitalization in CKD"],"prefix":"10.2215","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct01459770","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Katherine R.","family":"Tuttle","sequence":"first","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"},{"name":"Institute of Translational Health Sciences and"},{"name":"School of Medicine, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-0117","authenticated-orcid":false,"given":"Radica Z.","family":"Alicic","sequence":"additional","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"},{"name":"School of Medicine, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Short","sequence":"additional","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Neumiller","sequence":"additional","affiliation":[{"name":"Colleges of Pharmacy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Gates","sequence":"additional","affiliation":[{"name":"Colleges of Pharmacy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn B.","family":"Daratha","sequence":"additional","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"},{"name":"Nursing, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestina","family":"Barbosa-Leiker","sequence":"additional","affiliation":[{"name":"Nursing, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling M.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"},{"name":"School of Medicine, University of Washington, Seattle, Washington;"},{"name":"Medicine, Washington State University, Seattle, Washington; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi S.","family":"Chaytor","sequence":"additional","affiliation":[{"name":"Medicine, Washington State University, Seattle, Washington; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad P.","family":"Dieter","sequence":"additional","affiliation":[{"name":"Providence Health Care, Nephrology Division, Kidney Research Institute, Spokane, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Setter","sequence":"additional","affiliation":[{"name":"Colleges of Pharmacy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia 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