{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T20:59:07Z","timestamp":1794344347759,"version":"4.9.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK102511"],"award-info":[{"award-number":["K23DK102511"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Patients receiving maintenance hemodialysis (HD) have a high incidence of cardiac events, including arrhythmia and sudden death. Intradialytic hypotension (IDH) is a common complication of HD and is associated with development of reduced myocardial perfusion, a potential risk factor for arrhythmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      We analyzed data from the Monitoring in Dialysis study, which used implantable loop recorders to detect and continuously monitor electrocardiographic data from patients on maintenance HD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =66 from the United States and India) over a 6-month period (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =4720 sessions). Negative binomial mixed effects regression was used to test the association of IDH\n                      <jats:sub>20<\/jats:sub>\n                      (decline in systolic BP &gt;20 mm Hg from predialysis systolic BP) and IDH\n                      <jats:sub>0\u201320<\/jats:sub>\n                      (decline in systolic BP 0\u201320 mm Hg from predialysis systolic BP) with clinically significant arrhythmia (bradycardia\u226440 bpm for \u22656 seconds, asystole\u22653 seconds, ventricular tachycardia \u2265130 bpm for \u226530 seconds, or patient-marked events) during HD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of participants was 58 (25th\u201375th percentile, 49\u201366) years; 70% were male; and 65% were from the United States. IDH occurred in 2251 (48%) of the 4720 HD sessions analyzed, whereas IDH\n                      <jats:sub>0\u201320<\/jats:sub>\n                      occurred during 1773 sessions (38%). The number of sessions complicated by least one intradialytic clinically significant arrhythmia was 27 (1.2%) where IDH\n                      <jats:sub>20<\/jats:sub>\n                      occurred and 15 (0.8%) where IDH\n                      <jats:sub>0\u201320<\/jats:sub>\n                      occurred. Participants who experienced IDH\n                      <jats:sub>20<\/jats:sub>\n                      (versus not) had a nine-fold greater rate of developing an intradialytic clinically significant arrhythmia (incidence rate ratio, 9.4; 95% confidence interval, 3.0 to 29.4), whereas IDH\n                      <jats:sub>0\u201320<\/jats:sub>\n                      was associated with a seven-fold higher rate (incidence rate ratio, 7.2; 95% confidence interval, 2.1 to 25.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IDH is common in patients on maintenance HD and is associated with a greater risk of developing intradialytic clinically significant arrhythmia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.06810619","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T13:55:20Z","timestamp":1588859720000},"page":"805-812","source":"Crossref","is-referenced-by-count":40,"title":["Intradialytic Hypotension and Cardiac Arrhythmias in Patients Undergoing Maintenance Hemodialysis"],"prefix":"10.2215","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct01779856","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-0533","authenticated-orcid":false,"given":"Finnian R.","family":"Mc Causland","sequence":"first","affiliation":[{"name":"Renal Division and Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim A.","family":"Tumlin","sequence":"additional","affiliation":[{"name":"NephroNet Clinical Research Consortium, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir","family":"Roy-Chaudhury","sequence":"additional","affiliation":[{"name":"UNC Kidney Center, Chapel Hill, North Carolina"},{"name":"WG (Bill) Hefner VA Medical Center, Salisbury, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Koplan","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru I.","family":"Costea","sequence":"additional","affiliation":[{"name":"University of Cincinnati School of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Kher","sequence":"additional","affiliation":[{"name":"Medanta Kidney and Urology Institute, Medanta, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Williamson","sequence":"additional","affiliation":[{"name":"Southeastern Clinical Research Institute, Augusta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Pokhariyal","sequence":"additional","affiliation":[{"name":"Manipal Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Charytan","sequence":"additional","affiliation":[{"name":"New York University School of Medicine and NYU Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the MiD Investigators and 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