{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:44:37Z","timestamp":1786373077054,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Cardiovascular disease is the most common cause of death in CKD. This study evaluated whether electrocardiogram (ECG) abnormalities are predictors of cardiovascular death in CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      The Cardiovascular Health Study limited database (1989\u20132005) was used to identify a cohort with CKD at baseline (estimated GFR &lt; 60 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ). The patients were categorized as having major, minor, or no ECG abnormalities. Rates of adjudicated cardiovascular events and mortality were compared among the groups using proportional hazards regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1192 participants had CKD at baseline; mean age \u00b1 SD was 74.7\u00b16.2 years. Of these patients, 452 (38.8%) had major, 346 (29.7%) had minor, and 367 (31.5%) had no ECG abnormalities. Participants with estimated GFR &lt; 60 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      were more likely to have ECG abnormalities at baseline (adjusted prevalence odds ratio, 1.23 [95% confidence interval (CI), 1.06\u20131.43]) than those with GFR \u2265 60 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . During mean follow-up of 10.3\u00b13.8 years, 814 (68.3%) participants died. Compared with participants without ECG abnormalities, participants with major abnormalities had the highest risk for cardiovascular events and death; adjusted hazard ratios were 2.15 (95% CI, 1.56\u20132.98) and 2.27 (95% CI, 1.56\u20133.30), respectively. For minor ECG abnormalities, hazard ratios were 1.24 (95% CI, 0.91\u20131.70) and 1.48 (95% CI, 1.00\u20132.18), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with CKD, major ECG abnormalities are frequently present and predict a significantly higher risk for death and adverse cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.07440711","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T01:46:05Z","timestamp":1333071965000},"page":"949-956","source":"Crossref","is-referenced-by-count":29,"title":["Electrocardiogram Abnormalities and Cardiovascular Mortality in Elderly Patients with CKD"],"prefix":"10.2215","volume":"7","author":[{"given":"Mirela","family":"Dobre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Brateanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-12-20230811","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med"},{"key":"R3-12-20230811","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/ki.2011.223","article-title":"Cardiovascular disease in chronic kidney disease. 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