{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:02:23Z","timestamp":1793361743889,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201700001I"],"award-info":[{"award-number":["HHSN268201700001I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201700002I"],"award-info":[{"award-number":["HHSN268201700002I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201700003I"],"award-info":[{"award-number":["HHSN268201700003I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201700005I"],"award-info":[{"award-number":["HHSN268201700005I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN268201700004I"],"award-info":[{"award-number":["HHSN268201700004I"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK089174"],"award-info":[{"award-number":["R01DK089174"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2020,3]]},"abstract":"\n Background and objectives<\/jats:title>\n \n Exposure to particulate matter (PM) <2.5\n \u03bc<\/jats:italic>\n m in aerodynamic diameter (PM\n 2.5<\/jats:sub>\n ) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM\n 2.5<\/jats:sub>\n exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD.\n <\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996\u20131998 through 2016. Monthly mean PM\n 2.5<\/jats:sub>\n concentrations (\n \u03bc<\/jats:italic>\n g\/m\n 3<\/jats:sup>\n ) were estimated at geocoded participant addresses using geographic information system\u2013based, spatiotemporal generalized additive mixed models\u2014including geospatial covariates such as land use\u2014and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM\n 2.5<\/jats:sub>\n , baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM\n 2.5<\/jats:sub>\n and incident CKD (defined as follow-up eGFR <60 ml\/min per 1.73 m\n 2<\/jats:sup>\n with \u226525% eGFR decline relative to baseline, CKD-related hospitalization or death based on International Classification of Diseases 9\/10 codes, or development of ESKD) associations were estimated using Cox proportional hazards regression. Modeling was stratified by study site, and stratum-specific estimates were combined using random-effects meta-analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline mean participant age was 63 (\u00b16) years and eGFR was 86 (\u00b116) ml\/min per 1.73 m\n 2<\/jats:sup>\n . There was no significant PM\n 2.5<\/jats:sub>\n -eGFR association at baseline. Each 1-\n \u03bc<\/jats:italic>\n g\/m\n 3<\/jats:sup>\n higher annual average PM\n 2.5<\/jats:sub>\n was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1-\n \u03bc<\/jats:italic>\n g\/m\n 3<\/jats:sup>\n higher annual average PM\n 2.5<\/jats:sub>\n was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Exposure to higher annual average PM\n 2.5<\/jats:sub>\n concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.08350719","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T20:35:47Z","timestamp":1582835747000},"page":"311-319","source":"Crossref","is-referenced-by-count":107,"title":["Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD"],"prefix":"10.2215","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-6926","authenticated-orcid":false,"given":"Matthew F.","family":"Blum","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Surapaneni","sequence":"additional","affiliation":[{"name":"Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanping","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff D.","family":"Yanosky","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Whitsel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;"},{"name":"Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan E.","family":"Grams","sequence":"additional","affiliation":[{"name":"Division of Nephrology,"},{"name":"Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10590500802494538","article-title":"Airborne particulate matter and human health: Toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms","volume":"26","author":"Valavanidis","year":"2008","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0048-9697(99)00513-6","article-title":"Particulate matter in the atmosphere: which particle properties are important for its effects on health?","volume":"249","author":"Harrison","year":"2000","journal-title":"Sci Total 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