{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:32:11Z","timestamp":1789824731276,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Left ventricular hypertrophy (LVH) and abnormal systolic function are present in a high proportion of children with CKD. This study evaluated changes in left ventricular (LV) geometry and systolic function in children with mild to moderate CKD as an ancillary project of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of Chronic Renal Failure in Pediatric Patients trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>Echocardiograms and ambulatory BP monitoring were performed at baseline and at 1- or 2-year follow-up in 84 patients with CKD and 24-hour mean BP above the 50th percentile and\/or receiving fixed high-dose angiotensin converting enzyme inhibition and randomized to conventional or intensified BP control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LVH prevalence decreased from 38% to 25% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05). Changes in LV mass index (LVMI) were restricted to patients with LVH at baseline (\u22127.9 g\/m\n                      <jats:sup>2.7<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.02). Changes in LVMI were independent of randomization, reduction in BP, hemoglobin, and estimated GFR. A significant increase in midwall fractional shortening was observed in the total cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05), and was greater in the intensified group compared with the conventional BP control group (12%\u00b11.9% versus 8%\u00b11.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.05). In multivariate analysis, improvement in myocardial function was associated with reduction in BP (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      =\u22120.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05), independently of LVMI reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In children with CKD, angiotensin converting enzyme inhibition with improved BP control, LVH regression, and improved systolic function was observed within 12 months. Lowering BP to the low-normal range led to a slightly more marked improvement in myocardial function but not in LVMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.08420811","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T20:13:49Z","timestamp":1351973629000},"page":"203-210","source":"Crossref","is-referenced-by-count":91,"title":["Change in Cardiac Geometry and Function in CKD Children During Strict BP Control"],"prefix":"10.2215","volume":"8","author":[{"given":"Maria Chiara","family":"Matteucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Chinali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Rinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"W\u00fchl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Zurowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Charbit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Pongiglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20230811","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.CIR.0000049744.23613.69","article-title":"Left ventricular mass and systolic performance in pediatric patients with chronic renal failure.","volume":"107","author":"Mitsnefes","year":"2003","journal-title":"Circulation"},{"key":"R2-7-20230811","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2005030276","article-title":"Left ventricular geometry in children with mild to moderate chronic renal insufficiency.","volume":"17","author":"Matteucci","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"R3-7-20230811","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1681\/ASN.2006070691","article-title":"Reduced systolic myocardial function in children with chronic renal insufficiency.","volume":"18","author":"Chinali","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R4-7-20230811","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"R5-7-20230811","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-114-5-345","article-title":"Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension.","volume":"114","author":"Koren","year":"1991","journal-title":"Ann Intern Med"},{"key":"R6-7-20230811","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1001\/jama.1995.03520440046035","article-title":"The relative effects of left ventricular hypertrophy, coronary artery disease, and ventricular dysfunction on survival among black adults.","volume":"273","author":"Liao","year":"1995","journal-title":"JAMA"},{"key":"R7-7-20230811","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/01.CIR.97.1.48","article-title":"Prognostic significance of serial changes in left ventricular mass in essential hypertension.","volume":"97","author":"Verdecchia","year":"1998","journal-title":"Circulation"},{"key":"R8-7-20230811","doi-asserted-by":"crossref","first-page":"182S","DOI":"10.1093\/ajh\/5.6.182S","article-title":"Management of essential hypertension in patients with different degrees of left ventricular hypertrophy. 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