{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:21:34Z","timestamp":1790914894028,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Background and objectives<\/jats:title>\n Hypertension is the most important treatable risk factor for cardiovascular outcomes. Many patients with CKD are elderly, but the ideal BP in these individuals is unknown.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n From among 339,887 patients with incident eGFR<60 ml\/min per 1.73 m\n 2<\/jats:sup>\n , we examined associations of systolic BP (SBP) and diastolic BP (DBP) with all-cause mortality, incident coronary heart disease (CHD), ischemic strokes, and ESRD from the time of developing CKD until the end of follow-up (July 26, 2013, for mortality, CHD, and stroke, and December 31, 2011, for ESRD) in multivariable-adjusted survival models categorized by patients\u2019 age.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the total cohort, 300,424 (88%) had complete data for multivariable analysis. Both SBP and DBP showed a U-shaped association with mortality. SBP displayed a linear association with CHD, stroke, and ESRD, whereas DBP showed no consistent association with either. SBP>140 mmHg was associated with higher incidence of all examined outcomes, but with an incremental attenuation of the observed risk in older compared with younger patients (\n P<\/jats:italic>\n <0.05 for interaction) The adjusted hazard ratios and 95% confidence intervals associated with SBP\u2265170 mmHg (compared with 130\u2013139 mmHg) in patients <50, 50\u201359, 60\u201369, 70\u201379, and \u226580 years were 1.95 (1.34 to 2.84), 2.01 (1.75 to 2.30), 1.68 (1.49 to 1.89), 1.39 (1.25 to 1.54), and 1.30 (1.17 to 1.44), respectively. The risk of incident CHD, stroke, and ESRD was incrementally higher with higher SBP in patients aged <80 years but showed no consistent association in those aged \u226580 years (\n P<\/jats:italic>\n <0.05 for interaction for all outcomes).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In veterans with incident CKD, SBP showed different associations in older versus younger patients. The association of higher SBP with adverse outcomes was present but markedly reduced in older individuals, especially in those aged \u226580 years. Elevated DBP showed no consistent association with vascular outcomes in patients with incident CKD.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.08660815","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T22:38:11Z","timestamp":1461278291000},"page":"821-831","source":"Crossref","is-referenced-by-count":85,"title":["Age and Outcomes Associated with BP in Patients with Incident CKD"],"prefix":"10.2215","volume":"11","author":[{"given":"Csaba P.","family":"Kovesdy","sequence":"first","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"},{"name":"Nephrology Section, Memphis Veterans Affairs Medical Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alrifai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira O.","family":"Gosmanova","sequence":"additional","affiliation":[{"name":"Nehphrology Section, Straton Veterans Affairs Medical Center, Albany, New York;"},{"name":"Department of Medicine, Albany Medical College, Albany, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Canada","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry M.","family":"Wall","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"},{"name":"Nephrology Section, Memphis Veterans Affairs Medical Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M.","family":"Hung","sequence":"additional","affiliation":[{"name":"Nephrology Section, Nashville Veterans Affairs Medical Center, Nashville, Tennessee;"},{"name":"Division of Nephrology, Vanderbilt University, Nashville, Tennessee; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Kalantar-Zadeh","sequence":"additional","affiliation":[{"name":"Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California-Irvine, Orange, 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