{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:46:57Z","timestamp":1786373217851,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD018435"],"award-info":[{"award-number":["S10OD018435"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zell family foundation"},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK007135-46"],"award-info":[{"award-number":["5T32DK007135-46"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK103678"],"award-info":[{"award-number":["K01DK103678"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08DK109226"],"award-info":[{"award-number":["K08DK109226"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK090868"],"award-info":[{"award-number":["P30DK090868"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD), including evidence of vascular dysfunction, can begin in childhood. Curcumin is a polyphenol found in turmeric that reduces vascular dysfunction in rodent models and humans without ADPKD. It also slows kidney cystic progression in a murine model of ADPKD. We hypothesized that oral curcumin therapy would reduce vascular endothelial dysfunction and arterial stiffness in children\/young adults with ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      In a randomized, placebo-controlled, double-blind trial, 68 children\/young adults 6\u201325 years of age with ADPKD and eGFR&gt;80 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      were randomized to either curcumin supplementation (25 mg\/kg body weight per day) or placebo administered in powder form for 12 months. The coprimary outcomes were brachial artery flow-mediated dilation and aortic pulse-wave velocity. We also assessed change in circulating\/urine biomarkers of oxidative stress\/inflammation and kidney growth (height-adjusted total kidney volume) by magnetic resonance imaging. In a subgroup of participants \u226518 years, vascular oxidative stress was measured as the change in brachial artery flow-mediated dilation following an acute infusion of ascorbic acid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Enrolled participants were 18\u00b15 (mean \u00b1 SD) years, 54% were girls, baseline brachial artery flow-mediated dilation was 9.3\u00b14.1% change, and baseline aortic pulse-wave velocity was 512\u00b194 cm\/s. Fifty-seven participants completed the trial. Neither coprimary end point changed with curcumin (estimated change [95% confidence interval] for brachial artery flow-mediated dilation [percentage change]: curcumin: 1.14; 95% confidence interval, \u22120.84 to 3.13; placebo: 0.33; 95% confidence interval, \u22121.34 to 2.00; estimated difference for change: 0.81; 95% confidence interval, \u22121.21 to 2.84;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.48; aortic pulse-wave velocity [centimeters per second]: curcumin: 0.6; 95% confidence interval, \u221225.7 to 26.9; placebo: 6.5; 95% confidence interval, \u221220.4 to 33.5; estimated difference for change: \u22125.9; 95% confidence interval, \u221235.8 to 24.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.67; intent to treat). There was no curcumin-specific reduction in vascular oxidative stress or changes in mechanistic biomarkers. Height-adjusted total kidney volume also did not change as compared with placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Curcumin supplementation does not improve vascular function or slow kidney growth in children\/young adults with ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial registry name and registration number<\/jats:title>\n                    <jats:p>Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD, NCT02494141.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Podcast<\/jats:title>\n                    <jats:p>This article contains a podcast at https:\/\/www.asn-online.org\/media\/podcast\/CJASN\/2022_02_07_CJN08950621.mp3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.08950621","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T12:25:55Z","timestamp":1639484755000},"page":"240-250","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD"],"prefix":"10.2215","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02494141","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-3256","authenticated-orcid":false,"given":"Kristen L.","family":"Nowak","sequence":"first","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Farmer-Bailey","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases 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A.","family":"Cadnapaphornchai","sequence":"additional","affiliation":[{"name":"Rocky Mountain Pediatric Kidney Center, Rocky Mountain Hospital for Children at Presbyterian St. Luke\u2019s Medical Center, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"George","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, 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