{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:40:58Z","timestamp":1786372858970,"version":"build-2736575974"},"reference-count":78,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Over the past decade, genetic association studies have uncovered numerous determinants of kidney function in the general, diabetic, hypertensive, CKD, ESRD, and GN-based study populations (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , IgA nephropathy, membranous nephropathy, FSGS). These studies have led to numerous novel and unanticipated findings, which are helping improve our understanding of factors and pathways affecting both normal and pathologic kidney function. In this review, we report on major discoveries and advances resulting from this rapidly progressing research domain. We also predict some of the next steps the nephrology community should embrace to accelerate the identification of genetic and molecular processes leading to kidney dysfunction, pathophysiologically based disease subgroups, and specific therapeutic targets, as we attempt to transition toward a more precision-based medicine approach.\n                  <\/jats:p>","DOI":"10.2215\/cjn.09030817","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T20:25:37Z","timestamp":1513283137000},"page":"140-152","source":"Crossref","is-referenced-by-count":22,"title":["Lessons from CKD-Related Genetic Association Studies\u2013Moving Forward"],"prefix":"10.2215","volume":"13","author":[{"given":"Sophie","family":"Limou","sequence":"first","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie Unit\u00e9 Mixte de Recherche 1064, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 de Nantes, Nantes, France;"},{"name":"Institut de Transplantation Urologie et N\u00e9phrologie, Centre Hospitalier Universitaire Nantes, Nantes, France;"},{"name":"Ecole Centrale de Nantes, Nantes, France;"},{"name":"Basic Science Program, Basic Research Laboratory, National Cancer Institute\/National Institutes of Health, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Vince","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie Unit\u00e9 Mixte de Recherche 1064, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 de Nantes, Nantes, France;"},{"name":"Institut de Transplantation Urologie et N\u00e9phrologie, Centre Hospitalier Universitaire Nantes, Nantes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Parsa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland; and"},{"name":"Department of Medicine, Baltimore VA Medical Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"e0158765","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease - a systematic review and meta-analysis.","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","article-title":"Chronic kidney disease and cardiovascular risk: Epidemiology, mechanisms, and 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