{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:05:34Z","timestamp":1790111134162,"version":"4.0.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>The major goals of the Kidney Precision Medicine Project (KPMPP) are to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. In this clinical-pathologic-molecular correlation, we describe the case of a 38-year-old woman without any history of CKD who underwent a research kidney biopsy in the setting of AKI suspected to be due to nonsteroidal anti-inflammatory use after cesarean section delivery. The participant's histopathology was consistent with mild acute tubular injury, without significant interstitial fibrosis or tubular atrophy. This diagnosis was supported by analysis of the glomerular and tubulointerstitial proteomes. The proteomic interrogation revealed a molecular landscape that demonstrated differences in kidney prostaglandin synthesis that may be in response to nonsteroidal anti-inflammatory drugs and signs of intrarenal inflammation and fibrosis that were not evident by histopathology alone.<\/jats:p>","DOI":"10.2215\/cjn.09260822","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T14:10:17Z","timestamp":1667830217000},"page":"402-410","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of Nonsteroidal Anti-Inflammatory Drug\u2013Attributed Acute Kidney Injury"],"prefix":"10.2215","volume":"18","author":[{"given":"Samir V.","family":"Parikh","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sethu","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Knight","sequence":"additional","affiliation":[{"name":"The American Association of Kidney Patients, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi Z.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Division of Renal Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Rovin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Menez","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Kidney Precision Medicine Project","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"issue":"2","key":"B1-20250824","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ekir.2020.11.032","article-title":"Establishing a case for anti-complement therapy in membranous nephropathy","volume":"6","author":"Ayoub","year":"2021","journal-title":"Kidney Int Rep."},{"issue":"5","key":"B2-20250824","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/modpathol.2011.205","article-title":"Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli","volume":"25","author":"Satoskar","year":"2012","journal-title":"Mod Pathol."},{"issue":"1","key":"B3-20250824","doi-asserted-by":"crossref","first-page":"17179","DOI":"10.1038\/s41598-020-73847-x","article-title":"Differentiating Staphylococcus infection-associated glomerulonephritis and primary IgA nephropathy: a mass spectrometry-based exploratory study","volume":"10","author":"Satoskar","year":"2020","journal-title":"Sci Rep."},{"issue":"4","key":"B4-20250824","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/rheumatology\/keu408","article-title":"Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis","volume":"54","author":"Ungprasert","year":"2015","journal-title":"Rheumatology (Oxford)."},{"issue":"1","key":"B5-20250824","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","article-title":"Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int."},{"issue":"4","key":"B6-20250824","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0002-9440(10)63384-6","article-title":"Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules","volume":"165","author":"Kamijo","year":"2004","journal-title":"Am J Pathol."},{"issue":"1","key":"B7-20250824","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/cc12503","article-title":"Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury","volume":"17","author":"Kashani","year":"2013","journal-title":"Crit Care."},{"issue":"9466","key":"B8-20250824","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery","volume":"365","author":"Mishra","year":"2005","journal-title":"Lancet."},{"issue":"10","key":"B9-20250824","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1681\/ASN.2005030236","article-title":"Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit","volume":"16","author":"Parikh","year":"2005","journal-title":"J Am Soc Nephrol."},{"issue":"3","key":"B10-20250824","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1373\/jalm.2017.023325","article-title":"Biomarkers for early detection of acute kidney injury","volume":"2","author":"Rizvi","year":"2017","journal-title":"J Appl Lab Med."},{"issue":"1","key":"B11-20250824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/anr.1780320102","article-title":"The mechanisms of action of nonsteroidal antiinflammatory drugs","volume":"32","author":"Abramson","year":"1989","journal-title":"Arthritis Rheum."},{"issue":"9","key":"B12-20250824","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1056\/NEJM198403013100905","article-title":"Renal syndromes associated with nonsteroidal antiinflammatory drugs","volume":"310","author":"Clive","year":"1984","journal-title":"N Engl J Med."},{"issue":"1","key":"B13-20250824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ki.1987.164","article-title":"The clinical significance of inhibition of renal prostaglandin synthesis","volume":"32","author":"Patrono","year":"1987","journal-title":"Kidney Int."},{"issue":"7","key":"B14-20250824","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3390\/ph3072291","article-title":"Nonsteroidal anti-inflammatory drugs and the kidney","volume":"3","author":"H\u00f6rl","year":"2010","journal-title":"Pharmaceuticals (Basel)."},{"issue":"12","key":"B15-20250824","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/70995","article-title":"Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing","volume":"5","author":"Jones","year":"1999","journal-title":"Nat Med."},{"issue":"1","key":"B16-20250824","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1172\/JCI200318018","article-title":"Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells","volume":"112","author":"Peti-Peterdi","year":"2003","journal-title":"J Clin Invest."},{"issue":"41","key":"B17-20250824","doi-asserted-by":"crossref","first-page":"26586","DOI":"10.18632\/oncotarget.25005","article-title":"Prostaglandins in the pathogenesis of kidney diseases","volume":"9","author":"Li","year":"2018","journal-title":"Oncotarget."},{"issue":"3","key":"B18-20250824","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.ackd.2013.01.012","article-title":"Renal physiology of pregnancy","volume":"20","author":"Cheung","year":"2013","journal-title":"Adv Chronic Kidney Dis."},{"issue":"9","key":"B19-20250824","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1369\/0022155419849388","article-title":"Extracellular matrix in kidney fibrosis: more than just a scaffold","volume":"67","author":"B\u00fclow","year":"2019","journal-title":"J Histochem Cytochem."},{"issue":"1","key":"B20-20250824","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1755-1536-7-4","article-title":"The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?","volume":"7","author":"Genovese","year":"2014","journal-title":"Fibrogenesis Tissue Repair."},{"issue":"9","key":"B21-20250824","doi-asserted-by":"crossref","first-page":"e44891","DOI":"10.1371\/journal.pone.0044891","article-title":"Increased renal versican expression is associated with progression of chronic kidney disease","volume":"7","author":"Rudnicki","year":"2012","journal-title":"PLoS One."},{"issue":"3","key":"B22-20250824","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.kint.2020.08.039","article-title":"Rationale and design of the Kidney Precision Medicine Project","volume":"99","author":"de Boer","year":"2021","journal-title":"Kidney Int."},{"issue":"4","key":"B23-20250824","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2215\/CJN.10350721","article-title":"Molecular signatures of diabetic kidney disease hiding in a patient with hypertension-related kidney disease: A clinical pathologic molecular correlation","volume":"17","author":"Patel","year":"2021","journal-title":"Clin J Am Soc Nephrol."}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.09260822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:43:50Z","timestamp":1786369430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2215\/CJN.09260822"}},"subtitle":["A Clinical Pathologic Molecular Correlation"],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.09260822","relation":{},"ISSN":["1555-9041","1555-905X"],"issn-type":[{"value":"1555-9041","type":"print"},{"value":"1555-905X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]}}}