{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:18Z","timestamp":1792176018378,"version":"4.4.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Candidates with AKI including hepatorenal syndrome often recover renal function after successful liver transplantation (LT). This study examined the incidence and risk factors associated with renal nonrecovery within 6 months of LT alone among those receiving acute renal replacement therapy (RRT) before LT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>Scientific Registry of Transplant Recipients data were linked with Centers for Medicare and Medicaid Services ESRD data for 2112 adult deceased-donor LT-alone recipients who received acute RRT for \u226490 days before LT (February 28, 2002 to August 31, 2010). Primary outcome was renal nonrecovery (post-LT ESRD), defined as transition to chronic dialysis or waitlisting or receipt of kidney transplant within 6 months of LT. Cumulative incidence of renal nonrecovery was calculated using competing risk analysis. Cox regression identified recipient and donor predictors of renal nonrecovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cumulative incidence of renal nonrecovery after LT alone among those receiving the pre-LT acute RRT was 8.9%. Adjusted renal nonrecovery risk increased by 3.6% per day of pre-LT RRT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Age at LT per 5 years (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02), previous-LT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), and pre-LT diabetes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) were significant risk factors of renal nonrecovery. Twenty-one percent of recipients died within 6 months of LT. Duration of pretransplant RRT did not predict 6-month post-transplant mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among recipients on acute RRT before LT who survived after LT alone, the majority recovered their renal function within 6 months of LT. Longer pre-LT RRT duration, advanced age, diabetes, and re-LT were significantly associated with increased risk of renal nonrecovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.09600912","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T10:04:57Z","timestamp":1362132297000},"page":"1135-1142","source":"Crossref","is-referenced-by-count":77,"title":["Short-Term Pretransplant Renal Replacement Therapy and Renal Nonrecovery after Liver Transplantation Alone"],"prefix":"10.2215","volume":"8","author":[{"given":"Pratima","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Goodrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Guidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Schaubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Merion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20230811","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1600-6143.2006.01526.x","article-title":"Continued influence of preoperative renal function on outcome of orthotopic liver transplant (OLTX) in the US: Where will MELD lead us?","volume":"6","author":"Gonwa","year":"2006","journal-title":"Am J Transplant"},{"key":"R2-12-20230811","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1111\/j.1600-6143.2008.02416.x","article-title":"Proceedings of Concensus Conference on Simultaneous Liver Kidney Transplantation 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MELD.","volume":"37","author":"Moreau","year":"2003","journal-title":"Hepatology"},{"key":"R9-12-20230811","first-page":"440","article-title":"Pretransplant predictors of recovery of renal function after liver transplantation.","volume":"16","author":"Northup","year":"2010","journal-title":"Liver Transpl"},{"key":"R10-12-20230811","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1600-6143.2006.01277.x","article-title":"Analytical methods and database design: Implications for transplant researchers, 2005.","volume":"6","author":"Levine","year":"2006","journal-title":"Am J Transplant"},{"key":"R13-12-20230811","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/lt.21367","article-title":"Transplantation: Impact of pretransplant renal insufficiency.","volume":"14","author":"Bahirwani","year":"2008","journal-title":"Liver 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after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation.","volume":"11","author":"Campbell","year":"2005","journal-title":"Liver Transpl"},{"key":"R18-12-20230811","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/lt.21821","article-title":"Renal outcomes after liver transplantation in the model for end-stage liver disease era.","volume":"15","author":"Sharma","year":"2009","journal-title":"Liver Transpl"},{"key":"R19-12-20230811","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1111\/j.1600-6143.2012.04176.x","article-title":"Simultaneous liver-kidney transplantation: A survey of US transplant centers.","volume":"12","author":"Nadim","year":"2012","journal-title":"Am J Transplant"},{"key":"R20-12-20230811","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1111\/j.1600-6143.2012.04190.x","article-title":"Simultaneous liver-kidney transplantation summit: Current state and future 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