{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:49Z","timestamp":1790068729849,"version":"4.0.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) patients have an increased risk for intracranial aneurysms (IAs). The importance of screening for unruptured IAs (UIAs) depends on their risks for growth and rupture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>ADPKD patients with UIAs found by presymptomatic screening with magnetic resonance angiography (MRA) during 1989 to 2009 were followed initially at 6 months and annually, and less frequently after demonstration of stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-five saccular aneurysms were detected in 38 patients from 36 families. Most were small (median diameter 3.5 mm) and in the anterior circulation (84%). Median age at diagnosis was 49 years. During cumulative imaging follow-up of 243 years, one\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      UIA was detected and increased in size from 2 to 4.4 mm over 144 months and two UIAs grew from 4.5 to 5.9 mm and 4.7 to 6.2 mm after 69 and 184 months, respectively. Seven patients did not have imaging follow-up. No change was detected in the remaining 28 patients. During cumulative clinical follow-up of 316 years, no aneurysm ruptured. Five patients died from unrelated causes and two were lost to follow-up after 8 and 120 months. Three patients underwent surgical clipping.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most UIAs detected by presymptomatic screening in ADPKD patients are small and in the anterior circulation. Growth and rupture risks are not higher than those of UIAs in the general population. These data support very selective screening for UIAs in ADPKD patients, and widespread screening is not indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.09731110","type":"journal-article","created":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T23:41:41Z","timestamp":1304638901000},"page":"1274-1285","source":"Crossref","is-referenced-by-count":111,"title":["Extended Follow-Up of Unruptured Intracranial Aneurysms Detected by Presymptomatic Screening in Patients with Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.2215","volume":"6","author":[{"given":"Maria V.","family":"Irazabal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Huston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Kubly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Sundsbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente E.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20230811","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1681\/ASN.V131269","article-title":"Management of cerebral aneurysms in autosomal dominant polycystic kidney disease: Unruptured asymptomatic intracranial aneurysms","volume":"13","author":"Pirson","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R2-9-20230811","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00002142-200106000-00005","article-title":"Magnetic resonance angiography at 3.0 Tesla: Initial clinical experience","volume":"12","author":"Campeau","year":"2001","journal-title":"Top Magn Reson Imaging"},{"key":"R3-9-20230811","first-page":"84","article-title":"Improved image quality of intracranial aneurysms: 3.0-T versus 1.5-T time-of-flight MR angiography","volume":"25","author":"Gibbs","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"R5-9-20230811","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers","year":"2003","journal-title":"Lancet"},{"key":"R6-9-20230811","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S0140-6736(03)13773-7","article-title":"Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype","volume":"361","author":"Rossetti","year":"2003","journal-title":"Lancet"},{"key":"R7-9-20230811","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1523-1755.2004.00572.x","article-title":"Follow-up of intracranial aneurysms in autosomal-dominant polycystic kidney disease","volume":"65","author":"Gibbs","year":"2004","journal-title":"Kidney Int"},{"key":"R8-9-20230811","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1681\/ASN.V7102135","article-title":"Follow-up of intracranial aneurysms in autosomal dominant polycystic kidney disease by magnetic resonance angiography","volume":"7","author":"Huston","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"R9-9-20230811","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1681\/ASN.2006121387","article-title":"Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease","volume":"18","author":"Rossetti","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R10-9-20230811","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1681\/ASN.V84616","article-title":"Vascular expression of polycystin","volume":"8","author":"Griffin","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"R11-9-20230811","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1097\/01.ASN.0000080185.38113.A3","article-title":"Analysis of the polycystins in aortic vascular smooth muscle cells","volume":"14","author":"Qian","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R12-9-20230811","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1211","article-title":"Vascular expression of polycystin 2","volume":"12","author":"Torres","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"R13-9-20230811","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1073\/pnas.94.12.6397","article-title":"Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein","volume":"94","author":"Ibraghimov-Beskrovnaya","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R14-9-20230811","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/hmg\/ddh336","article-title":"Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease","volume":"13","author":"Lantinga-van Leeuwen","year":"2004","journal-title":"Hum Mol Genet"},{"key":"R15-9-20230811","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddg190","article-title":"Pkd2 haploinsufficiency alters intracellular calcium in vascular smooth muscle cells","volume":"12","author":"Qian","year":"2003","journal-title":"Hum Mol Genet"},{"key":"R16-9-20230811","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1056\/NEJM199209243271303","article-title":"Intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"327","author":"Chapman","year":"1992","journal-title":"N Engl J Med"},{"key":"R17-9-20230811","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1681\/ASN.V3121871","article-title":"Value of magnetic resonance angiography for the detection of intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"3","author":"Huston","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"R18-9-20230811","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1148\/radiology.191.1.8134594","article-title":"Occult intracranial aneurysms in polycystic kidney disease: Screening with MR angiography","volume":"191","author":"Ruggieri","year":"1994","journal-title":"Radiology"},{"key":"R19-9-20230811","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1474-4422(05)00993-2","article-title":"Intracranial aneurysm screening: Indications and advice for practice","volume":"4","author":"Rinkel","year":"2005","journal-title":"Lancet Neurol"},{"key":"R20-9-20230811","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3171\/JNS\/2008\/108\/6\/1132","article-title":"Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection","volume":"108","author":"Brown","year":"2008","journal-title":"J Neurosurg"},{"key":"R21-9-20230811","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/STROKEAHA.108.519165","article-title":"Intracranial aneurysm enlargement on serial magnetic resonance angiography: Frequency and risk factors","volume":"40","author":"Burns","year":"2009","journal-title":"Stroke"},{"key":"R22-9-20230811","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3171\/jns.2004.101.6.0908","article-title":"Incidence and risk factors for the growth of unruptured cerebral aneurysms: Observation using serial computerized tomography angiography","volume":"101","author":"Matsubara","year":"2004","journal-title":"J Neurosurg"},{"key":"R23-9-20230811","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1227\/01.NEU.0000217366.02567.D2","article-title":"Risk factors for growth of unruptured intracranial aneurysms: Follow-up study by serial 0.5-T magnetic resonance angiography","volume":"58","author":"Miyazawa","year":"2006","journal-title":"Neurosurgery"},{"key":"R24-9-20230811","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/01.STR.0000199077.06390.35","article-title":"Yield of short-term follow-up CT\/MR angiography for small aneurysms detected at screening","volume":"37","author":"Wermer","year":"2006","journal-title":"Stroke"},{"key":"R25-9-20230811","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3171\/jns.1987.66.1.0023","article-title":"The significance of unruptured intracranial saccular aneurysms","volume":"66","author":"Wiebers","year":"1987","journal-title":"J Neurosurg"},{"key":"R26-9-20230811","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/STROKEAHA.108.521674","article-title":"Unruptured intracranial aneurysms: Incidence of rupture and risk factors","volume":"40","author":"Ishibashi","year":"2009","journal-title":"Stroke"},{"key":"R27-9-20230811","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3171\/jns.2000.93.3.0379","article-title":"Natural history of unruptured intracranial aneurysms: Probability of and risk factors for aneurysm rupture","volume":"93","author":"Juvela","year":"2000","journal-title":"J Neurosurg"},{"key":"R28-9-20230811","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1097\/00006123-199706000-00007","article-title":"Long-term follow-up study of unruptured intracranial aneurysms","volume":"40","author":"Yasui","year":"1997","journal-title":"Neurosurgery"},{"key":"R29-9-20230811","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neurad.2007.11.004","article-title":"Natural history, epidemiology and screening of unruptured intracranial aneurysms","volume":"35","author":"Rinkel","year":"2008","journal-title":"J Neuroradiol"},{"key":"R30-9-20230811","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1093\/brain\/awn187","article-title":"Risk of subarachnoid haemorrhage according to number of affected relatives: A population based case-control study","volume":"131","author":"Bor","year":"2008","journal-title":"Brain"},{"key":"R31-9-20230811","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/STROKEAHA.108.542571","article-title":"Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms","volume":"40","author":"Broderick","year":"2009","journal-title":"Stroke"},{"key":"R32-9-20230811","first-page":"146","article-title":"Treatment of unruptured intracranial aneurysms: A nationwide assessment of effectiveness","volume":"28","author":"Higashida","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"R33-9-20230811","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/1531-8249(200007)48:1<11::AID-ANA4>3.0.CO;2-V","article-title":"Endovascular and surgical treatment of unruptured cerebral aneurysms: Comparison of risks","volume":"48","author":"Johnston","year":"2000","journal-title":"Ann Neurol"},{"key":"R34-9-20230811","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3171\/jns.1994.81.6.0837","article-title":"Morbidity and mortality from elective surgery for asymptomatic, unruptured, intracranial aneurysms: A meta-analysis","volume":"81","author":"King","year":"1994","journal-title":"J Neurosurg"},{"key":"R35-9-20230811","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1227\/01.NEU.0000137653.93173.1C","article-title":"Treatment of unruptured cerebral aneurysms by embolization with guglielmi detachable coils: Case-fatality, morbidity, and effectiveness in preventing bleeding\u2014A systematic review of the literature","volume":"55","author":"Lanterna","year":"2004","journal-title":"Neurosurgery"},{"key":"R36-9-20230811","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/01.STR.29.8.1531","article-title":"Mortality and morbidity of surgery for unruptured intracranial aneurysms: A meta-analysis","volume":"29","author":"Raaymakers","year":"1998","journal-title":"Stroke"},{"key":"R37-9-20230811","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1161\/STROKEAHA.107.496372","article-title":"Endovascular treatment of unruptured intracranial aneurysms with Guglielmi detachable coils: Short- and long-term results of a single-centre series","volume":"39","author":"Standhardt","year":"2008","journal-title":"Stroke"},{"key":"R38-9-20230811","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1097\/00006123-200006000-00003","article-title":"What percentage of surgically clipped intracranial aneurysms have residual necks?","volume":"46","author":"Thornton","year":"2000","journal-title":"Neurosurgery"},{"key":"R39-9-20230811","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3171\/jns.1999.91.3.0396","article-title":"Late angiographic follow-up review of surgically treated aneurysms","volume":"91","author":"David","year":"1999","journal-title":"J Neurosurg"},{"key":"R40-9-20230811","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.STR.32.5.1191","article-title":"Risk of aneurysm recurrence in patients with clipped cerebral aneurysms: Results of long-term follow-up angiography","volume":"32","author":"Tsutsumi","year":"2001","journal-title":"Stroke"},{"key":"R41-9-20230811","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11910-009-0002-0","article-title":"Treatment of unruptured intracranial aneurysms: Surgery, coiling, or nothing?","volume":"9","author":"Burns","year":"2009","journal-title":"Curr Neurol Neurosci Rep"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201106000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:40:47Z","timestamp":1786369247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201106000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.09731110","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11771964.12863062","asserted-by":"object"}]},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}