{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:43:45Z","timestamp":1786373025397,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background and objectives<\/jats:title>\n Studies using high-resolution peripheral quantitative computed tomography showed progressive abnormalities in cortical and trabecular microarchitecture and biomechanical competence over the first year after kidney transplantation. However, high-resolution peripheral computed tomography is a research tool lacking wide availability. In contrast, the trabecular bone score is a novel and widely available tool that uses gray-scale variograms of the spine image from dual-energy x-ray absorptiometry to assess trabecular quality. There are no studies assessing whether trabecular bone score characterizes bone quality in kidney transplant recipients.<\/jats:p>\n <\/jats:sec>\n \n Design, settings, participants, & measurements<\/jats:title>\n Between 2009 and 2010, we conducted a study to assess changes in peripheral skeletal microarchitecture, measured by high-resolution peripheral computed tomography, during the first year after transplantation in 47 patients managed with early corticosteroid\u2013withdrawal immunosuppression. All adult first-time transplant candidates were eligible. Patients underwent imaging with high-resolution peripheral computed tomography and dual-energy x-ray absorptiometry pretransplantation and 3, 6, and 12 months post-transplantation. We now test if, during the first year after transplantation, trabecular bone score assesses the evolution of bone microarchitecture and biomechanical competence as determined by high-resolution peripheral computed tomography.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At baseline and follow-up, among the 72% and 78%, respectively, of patients having normal bone mineral density by dual-energy x-ray absorptiometry, 53% and 50%, respectively, were classified by trabecular bone score as having high fracture risk. At baseline, trabecular bone score correlated with spine, hip, and ultradistal radius bone mineral density by dual-energy x-ray absorptiometry and cortical area, density, thickness, and porosity; trabecular density, thickness, separation, and heterogeneity; and stiffness and failure load by high-resolution peripheral computed tomography. Longitudinally, each percentage increase in trabecular bone score was associated with increases in trabecular number (0.35%\u00b11.4%); decreases in trabecular thickness (\u22120.45%\u00b10.15%), separation (\u22120.40%\u00b10.15%), and network heterogeneity (\u22120.48%\u00b10.20%); and increases in failure load (0.22%\u00b10.09%) by high-resolution peripheral computed tomography (all\n P<\/jats:italic>\n <0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Trabecular bone score may be a useful method to assess and monitor bone quality and strength and classify fracture risk in kidney transplant recipients.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.09850916","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T20:21:12Z","timestamp":1490646072000},"page":"644-652","source":"Crossref","is-referenced-by-count":36,"title":["Spine Trabecular Bone Score as an Indicator of Bone Microarchitecture at the Peripheral Skeleton in Kidney Transplant Recipients"],"prefix":"10.2215","volume":"12","author":[{"given":"Matthew","family":"Luckman","sequence":"first","affiliation":[{"name":"Institute of Human Nutrition and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Hans","sequence":"additional","affiliation":[{"name":"Center of Bone Diseases, Bone and Joint Department, Medical University of Lausanne, Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cortez","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle K.","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Agarawal","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Nikkel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, University of Rochester, Rochester, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kaiser Oakland Medical Center, Oakland, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward X.","family":"Guo","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, Columbia University, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Nickolas","sequence":"additional","affiliation":[{"name":"Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1681\/ASN.2013080851","article-title":"Kidney transplantation with early corticosteroid withdrawal: Paradoxical effects at the central and peripheral skeleton.","volume":"25","author":"Iyer","year":"2014","journal-title":"J Am Soc 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