{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:36:14Z","timestamp":1790368574344,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Because little is known about long-term treatment-related nephrotoxicity, the aim was to determine risk factors for renal impairment long after childhood cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>\n                      Data from 763 adult childhood cancer survivors (414 men) were obtained during regular visits at the late-effects clinic between 2003 and 2009. Median follow-up time was 18.3 years (range=5.0\u201358.2). Glomerular function was assessed by estimated GFR (using the Modification of Diet in Renal Disease formula), urinary albumin creatinine ratio, and tubular function by urinary\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      -microglobulin creatinine ratio. The association with treatment factors was analyzed with covariance analysis for estimated GFR and logistic regression for urinary albumin and urinary\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      -microglobulin creatinine ratios.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Survivors treated with nephrectomy and abdominal irradiation had significantly lower estimated GFR than survivors not treated with nephrectomy\/abdominal irradiation (estimated mean=90 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      versus 106,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Estimated GFR was significantly lower in survivors after treatment with high-dose ifosfamide (88 versus 98,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) and high-dose cisplatin (83 versus 101,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004) compared with survivors not treated with these regimen. Nephrectomy combined with abdominal radiotherapy (odds ratio=3.14, 95% confidence interval=1.02; 9.69) and high-dose cisplatin (odds ratio=5.19, 95% confidence interval=1.21; 22.21) was associated with albuminuria. High-dose ifosfamide (odds ratio=6.19, 95% confidence interval=2.45; 15.67) was associated with increased urinary\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      -microglobulin creatinine ratio. Hypertension was present in 23.4% of survivors and 31.4% of renal tumor survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with unilateral nephrectomy, abdominal radiotherapy, cisplatin, and ifosfamide was associated with lower estimated GFR. Persisting tubular damage was related to ifosfamide treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.09980912","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T01:10:20Z","timestamp":1360890620000},"page":"922-929","source":"Crossref","is-referenced-by-count":105,"title":["Long-Term Nephrotoxicity in Adult Survivors of Childhood Cancer"],"prefix":"10.2215","volume":"8","author":[{"given":"Ilona A.","family":"Dekkers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Blijdorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlien","family":"Cransberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia M.","family":"Pluijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J.","family":"Neggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20230811","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3322\/caac.21149","article-title":"Cancer treatment and survivorship statistics, 2012.","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"R2-7-20230811","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/canjclin.55.1.10","article-title":"Cancer statistics, 2005.","volume":"55","author":"Jemal","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"R3-7-20230811","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1200\/JCO.2008.21.1425","article-title":"Late mortality among 5-year survivors of childhood cancer: A summary from the Childhood Cancer Survivor Study.","volume":"27","author":"Armstrong","year":"2009","journal-title":"J Clin Oncol"},{"key":"R4-7-20230811","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer.","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"R5-7-20230811","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/pbc.21695","article-title":"Renal late effects in patients treated for cancer in childhood: A report from the Children\u2019s Oncology Group.","volume":"51","author":"Jones","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"R6-7-20230811","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002280100319","article-title":"Pharmacokinetics of cisplatin and relation to nephrotoxicity in paediatric patients.","volume":"57","author":"Erdlenbruch","year":"2001","journal-title":"Eur J Clin Pharmacol"},{"key":"R7-7-20230811","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/1097-0142(19951215)76:12<2557::AID-CNCR2820761223>3.0.CO;2-9","article-title":"A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults.","volume":"76","author":"Ho","year":"1995","journal-title":"Cancer"},{"key":"R8-7-20230811","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00008480-199504000-00016","article-title":"Renal toxicity of cancer chemotherapeutic agents in children: Ifosfamide and cisplatin.","volume":"7","author":"Jones","year":"1995","journal-title":"Curr Opin Pediatr"},{"key":"R9-7-20230811","first-page":"286","article-title":"Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor.","volume":"16","author":"Raney","year":"1994","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"R10-7-20230811","first-page":"1636","article-title":"Risk factors for nephrotoxicity after ifosfamide treatment in children: A UKCCSG Late Effects Group study.","volume":"82","author":"Skinner","year":"2000","journal-title":"Br J Cancer"},{"key":"R11-7-20230811","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/MPH.0b013e3181f8cac0","article-title":"Nephrotoxicity\u2014what do we know and what don\u2019t we know?","volume":"33","author":"Skinner","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"R12-7-20230811","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1681\/ASN.2004030203","article-title":"Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999.","volume":"16","author":"Foley","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R13-7-20230811","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1046\/j.1523-1755.2003.00838.x","article-title":"Level of kidney function as a risk factor for cardiovascular outcomes in the elderly.","volume":"63","author":"Manjunath","year":"2003","journal-title":"Kidney Int"},{"key":"R14-7-20230811","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1046\/j.1523-1755.2002.00522.x","article-title":"Cardiovascular disease risk status in elderly persons with renal insufficiency.","volume":"62","author":"Shlipak","year":"2002","journal-title":"Kidney Int"},{"key":"R15-7-20230811","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis.","volume":"375","author":"Matsushita","year":"2010","journal-title":"Lancet"},{"key":"R16-7-20230811","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ki.2010.536","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts.","volume":"79","author":"van der Velde","year":"2011","journal-title":"Kidney Int"},{"key":"R17-7-20230811","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"R18-7-20230811","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation.","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"R19-7-20230811","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-139-2-200307150-00013","article-title":"National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification.","volume":"139","author":"Levey","year":"2003","journal-title":"Ann Intern Med"},{"key":"R20-7-20230811","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","article-title":"Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values.","volume":"53","author":"Levey","year":"2007","journal-title":"Clin Chem"},{"key":"R21-7-20230811","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.ki.5002374","article-title":"Age- and gender-specific reference values of estimated GFR in Caucasians: The Nijmegen Biomedical Study.","volume":"72","author":"Wetzels","year":"2007","journal-title":"Kidney Int"},{"key":"R22-7-20230811","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archinte.1987.00370050135022","article-title":"Quantitation of proteinuria by the use of protein-to-creatinine ratios in single urine samples.","volume":"147","author":"Schwab","year":"1987","journal-title":"Arch Intern Med"},{"key":"R23-7-20230811","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1111\/j.1523-1755.2005.09805.x","article-title":"The kidney, a cardiovascular risk marker, and a new target for therapy.","volume":"98","author":"de Zeeuw","year":"2005","journal-title":"Kidney Int Suppl"},{"key":"R24-7-20230811","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/mpo.10336","article-title":"Chronic ifosfamide nephrotoxicity in children.","volume":"41","author":"Skinner","year":"2003","journal-title":"Med Pediatr Oncol"},{"key":"R25-7-20230811","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0022-3476(85)80098-6","article-title":"Renal toxicity of cisplatin in children.","volume":"106","author":"Womer","year":"1985","journal-title":"J Pediatr"},{"key":"R26-7-20230811","first-page":"3767","article-title":"Comparative study of the acute nephrotoxicity from standard dose cisplatin ifosfamide and high-dose chemotherapy with carboplatin and ifosfamide.","volume":"20","author":"Hartmann","year":"2000","journal-title":"Anticancer Res"},{"key":"R27-7-20230811","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s004670050585","article-title":"Renal involvement in children with malignancies.","volume":"13","author":"Rossi","year":"1999","journal-title":"Pediatr Nephrol"},{"key":"R28-7-20230811","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.2215\/CJN.09620911","article-title":"Renal dysfunction and elevated blood pressure in long-term childhood cancer survivors.","volume":"7","author":"Knijnenburg","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"R29-7-20230811","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/sj.ki.5000141","article-title":"Renal albumin absorption in physiology and pathology.","volume":"69","author":"Birn","year":"2006","journal-title":"Kidney Int"},{"key":"R30-7-20230811","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/212546a0","article-title":"Albumin absorption by renal proximal tubule cells.","volume":"212","author":"Maunsbach","year":"1966","journal-title":"Nature"},{"key":"R31-7-20230811","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/ndt\/14.11.2628","article-title":"Secretion of chemokines and cytokines by human tubular epithelial cells in response to proteins.","volume":"14","author":"Burton","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"R32-7-20230811","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/ndt\/gfh561","article-title":"High molecular weight plasma proteins induce apoptosis and Fas\/FasL expression in human proximal tubular cells.","volume":"20","author":"Morais","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R33-7-20230811","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000042803.28024.92","article-title":"Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells.","volume":"14","author":"Townsend","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R34-7-20230811","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2165\/00003088-200140010-00004","article-title":"Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.","volume":"40","author":"Kerbusch","year":"2001","journal-title":"Clin Pharmacokinet"},{"key":"R35-7-20230811","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/mp100329u","article-title":"New clues for nephrotoxicity induced by ifosfamide: Preferential renal uptake via the human organic cation transporter 2.","volume":"8","author":"Ciarimboli","year":"2011","journal-title":"Mol Pharm"},{"key":"R36-7-20230811","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/pbc.24118","article-title":"Rhabdomyosarcoma: Review of the Children\u2019s Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies.","volume":"59","author":"Malempati","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"R37-7-20230811","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/humrep\/den487","article-title":"Assessment of ovarian reserve in adult childhood cancer survivors using anti-M\u00fcllerian hormone.","volume":"24","author":"Lie Fong","year":"2009","journal-title":"Hum Reprod"},{"key":"R38-7-20230811","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/humrep\/deq029","article-title":"Pregnancy outcome in female childhood cancer survivors.","volume":"25","author":"Lie Fong","year":"2010","journal-title":"Hum Reprod"},{"key":"R39-7-20230811","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/mpo.10293","article-title":"Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney function.","volume":"40","author":"Hempel","year":"2003","journal-title":"Med Pediatr Oncol"},{"key":"R40-7-20230811","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/cncr.20255","article-title":"High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma.","volume":"100","author":"Widemann","year":"2004","journal-title":"Cancer"},{"key":"R41-7-20230811","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1056\/NEJM198209093071104","article-title":"Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease.","volume":"307","author":"Brenner","year":"1982","journal-title":"N Engl J Med"},{"key":"R42-7-20230811","first-page":"2371","article-title":"Long-term consequences of kidney donation.","volume":"360","author":"Dols","year":"2009","journal-title":"N Engl J Med"},{"key":"R43-7-20230811","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/sj.ki.5001819","article-title":"Proteinuria and reduced kidney function in living kidney donors: A systematic review, meta-analysis, and meta-regression.","volume":"70","author":"Garg","year":"2006","journal-title":"Kidney Int"},{"key":"R44-7-20230811","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0272-6386(12)80032-1","article-title":"Renal function up to 50 years after unilateral nephrectomy in childhood.","volume":"21","author":"Baudoin","year":"1993","journal-title":"Am J Kidney Dis"},{"key":"R45-7-20230811","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/pbc.20886","article-title":"Hypertension and prehypertension in long-term survivors of childhood and adolescent cancer.","volume":"49","author":"Haddy","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"R46-7-20230811","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1210\/jc.2006-0128","article-title":"Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: Prevalence and risk factors.","volume":"91","author":"Neville","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R47-7-20230811","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1161\/01.CIR.0000146378.65439.7A","article-title":"Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria.","volume":"110","author":"Asselbergs","year":"2004","journal-title":"Circulation"}],"container-title":["Clinical Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01277230-201306000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:43:02Z","timestamp":1786369382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01277230-201306000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2215\/cjn.09980912","relation":{},"ISSN":["1555-9041"],"issn-type":[{"value":"1555-9041","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}