{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:38:02Z","timestamp":1786372682813,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Background and objectives<\/jats:title>\n Two recent studies reported increased risk of ESRD after kidney donation. In both, the majority of ESRD was seen in those donating to a relative. Confounding this observation is that, in the absence of donation, relatives of those with ESRD are at increased risk for ESRD. Understanding the pathogenesis and risk factors for postdonation ESRD is critical for both donor selection and counseling.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n \n We hypothesized that if familial relationship was an important consideration in pathogenesis, the donor and linked recipient would share ESRD etiology. We obtained information from the Organ Procurement and Transplantation Network (OPTN) on all living kidney donors subsequently waitlisted for a kidney transplant in the United States between January 1, 1996 and November 30, 2015, to determine (\n 1<\/jats:italic>\n ) the donor\u2013recipient relationship and (\n 2<\/jats:italic>\n ) whether related donor\u2013recipient pairs had similar causes of ESRD.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We found that a significant amount of information, potentially available at the time of listing, was not reported to the OPTN. Of 441 kidney donors listed for transplant, only 169 had information allowing determination of interval from donation to listing, and only 99 (22% of the total) had information on the donor\u2013recipient relationship and ESRD etiology. Of the 99 donors, 87 were related to their recipient. Strikingly, of the 87, only a minority (23%) of donor\u2013recipient pairs shared ESRD etiology. Excluding hypertension, only 8% shared etiology.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A better understanding of ESRD in donors requires complete and detailed data collection, as well as a method to capture all ESRD end points. This study highlights the absence of critical information that is urgently needed to provide a meaningful understanding of ESRD after kidney donation. We found that of living related donors listed for transplant, where both donor and recipient cause of ESRD is recorded, only a minority share ESRD etiology with their recipient.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.11421116","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T20:31:01Z","timestamp":1488400261000},"page":"663-668","source":"Crossref","is-referenced-by-count":23,"title":["A Case-Based Analysis of Whether Living Related Donors Listed for Transplant Share ESRD Causes with Their Recipients"],"prefix":"10.2215","volume":"12","author":[{"given":"Arthur J.","family":"Matas","sequence":"first","affiliation":[{"name":"Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Hays","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Transplant Clinic, University of Wisconsin Hospital and Clinics, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan N.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Medicine, University of Minnesota, Minneapolis, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/01.tp.0000250728.73268.e3","article-title":"Incidence of end-stage renal disease among live kidney donors.","volume":"82","author":"Fehrman-Ekholm","year":"2006","journal-title":"Transplantation"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa0804883","article-title":"Long-term consequences of kidney donation.","volume":"360","author":"Ibrahim","year":"2009","journal-title":"N Engl J Med"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/TP.0b013e318192dc95","article-title":"Short- and long-term donor outcomes after kidney donation: Analysis of 601 cases over a 35-year period at Japanese single center.","volume":"87","author":"Okamoto","year":"2009","journal-title":"Transplantation"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ndt\/gfr303","article-title":"Overall and cardiovascular mortality in Norwegian kidney donors compared to the background population.","volume":"27","author":"Mj\u00f8en","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1432-2277.2012.01439.x","article-title":"Very long-term follow-up of living kidney donors.","volume":"25","author":"Fournier","year":"2012","journal-title":"Transpl Int"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors.","volume":"86","author":"Mj\u00f8en","year":"2014","journal-title":"Kidney 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end-stage renal disease in African Americans.","volume":"21","author":"Freedman","year":"1993","journal-title":"Am J Kidney Dis"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1681\/ASN.V971270","article-title":"Familial aggregation of renal disease in a population-based case-control study.","volume":"9","author":"Lei","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0272-6386(96)90356-X","article-title":"Kidney disease in the first-degree relatives of African-Americans with hypertensive end-stage renal disease.","volume":"27","author":"Bergman","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0272-6386(98)70135-0","article-title":"Higher risk for renal failure in first-degree relatives of white patients with end-stage renal disease: A population-based study.","volume":"32","author":"O\u2019Dea","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2215\/CJN.01680214","article-title":"Familial clustering of ESRD in the Norwegian population.","volume":"9","author":"Skrunes","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"B16-20230813","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/j.ajkd.2015.01.032","article-title":"Living kidney donors and ESRD.","volume":"66","author":"Ross","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"B17-20230813","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2014030302","article-title":"Kidney transplant outcomes for prior living organ donors.","volume":"26","author":"Potluri","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B18-20230813","article-title":"Patterns of end-stage renal disease caused by diabetes, hypertension, and glomerulonephritis in live kidney 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