{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:35:22Z","timestamp":1791038122487,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening.<\/jats:p>","DOI":"10.2215\/cjn.11571017","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T09:20:11Z","timestamp":1522747211000},"page":"1605-1611","source":"Crossref","is-referenced-by-count":244,"title":["Nephrotoxicity and Chinese Herbal Medicine"],"prefix":"10.2215","volume":"13","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;"},{"name":"International Renal Research Institute of Vicenza and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xie","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza and"},{"name":"Department of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maojuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell H.","family":"Rosner","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[{"name":"International Renal Research Institute of Vicenza and"},{"name":"Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4065\/82.5.561","article-title":"Use of herbs among adults based on evidence-based indications: Findings from the National Health Interview Survey","volume":"82","author":"Bardia","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"B3-20230813","first-page":"S27","article-title":"The art and science of traditional medicine. 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