{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:42:25Z","timestamp":1790764945630,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","funder":[{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Although most patients receiving maintenance dialysis exhibit initial seroresponse to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, concerns exist regarding the durability of this antibody response. This study evaluated seroresponse over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients on maintenance dialysis, from a midsize national dialysis provider, who received a complete SARS-CoV-2 vaccine series and had at least one antibody titer checked after full vaccination. IgG spike antibodies (anti-spike IgG) titers were assessed monthly with routine laboratory tests after vaccination; the semiquantitative assay reported a range between zero and \u226520 Index. Descriptive analyses compared trends over time by history of coronavirus disease 2019 (COVID-19) and vaccine type. Time-to-event analyses examined the outcome of loss of seroresponse (anti-spike IgG &lt;1 Index or development of COVID-19). Cox regression adjusted for additional clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1870 patients receiving maintenance dialysis, 1569 had no prior COVID-19. Patients without prior COVID-19 had declining titers over time. Among 443 recipients of BNT162b2 (Pfizer), median (interquartile range) anti-spike IgG titer declined from \u226520 (5.89 to \u226520) in month 1 after full vaccination to 1.96 (0.60\u20135.88) by month 6. Among 778 recipients of mRNA-1273 (Moderna), anti-spike IgG titer declined from \u226520 (interquartile range, \u226520 to \u226520) in month 1 to 7.99 (2.61 to \u226520) by month 6. The 348 recipients of Ad26.COV2.S (Janssen) had a lower titer response than recipients of an mRNA vaccine over all time periods. In time-to-event analyses, recipients of Ad26.COV2.S and mRNA-1273 had the shortest and longest time to loss of seroresponse, respectively. The maximum titer reached in the first 2 months after full vaccination was associated with durability of the anti-spike IgG seroresponse; patients with anti-spike IgG titer 1\u201319.99 had a shorter time to loss of seroresponse compared with patients with anti-spike IgG titer \u226520 (hazard ratio, 15.5; 95% confidence interval, 11.7 to 20.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients receiving maintenance dialysis, vaccine-induced seroresponse wanes over time across vaccine types. Early titers after full vaccination are associated with the durability of seroresponse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.12250921","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T11:30:25Z","timestamp":1644492625000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":53,"title":["Seroresponse to SARS-CoV-2 Vaccines among Maintenance Dialysis Patients over 6 Months"],"prefix":"10.2215","volume":"17","author":[{"given":"Caroline M.","family":"Hsu","sequence":"first","affiliation":[{"name":"Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold J.","family":"Manley","sequence":"additional","affiliation":[{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon N.","family":"Aweh","sequence":"additional","affiliation":[{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Ladik","sequence":"additional","affiliation":[{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Frament","sequence":"additional","affiliation":[{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Miskulin","sequence":"additional","affiliation":[{"name":"Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Argyropoulos","sequence":"additional","affiliation":[{"name":"University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Abreo","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Sciences Center, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chin","sequence":"additional","affiliation":[{"name":"University of California, Davis, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald","family":"Gladish","sequence":"additional","affiliation":[{"name":"Nephrology of North Alabama, Decatur, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loay","family":"Salman","sequence":"additional","affiliation":[{"name":"Albany Medical College, Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Johnson","sequence":"additional","affiliation":[{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo K.","family":"Lacson","sequence":"additional","affiliation":[{"name":"Tufts Medical Center, Boston, Massachusetts"},{"name":"Dialysis Clinic Inc., Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"B2-20241015","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N Engl J Med"},{"key":"B3-20241015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N Engl J 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History"}},{"value":"2022-01-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}