{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:14:14Z","timestamp":1792080854310,"version":"4.4.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81470956"],"award-info":[{"award-number":["No. 81470956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81500543"],"award-info":[{"award-number":["No. 81500543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Patients with monoclonal gammopathy and concomitant kidney diseases are frequently found in clinical practice. Some of them are diagnosed with monoclonal gammopathy of renal significance (MGRS) due to the presence of monoclonal Ig\u2013related kidney injuries. This study aimed to investigate the histopathologic spectrum and clinical characteristics associated with MGRS in a large cohort of patients with monoclonal gammopathy and biopsy-proven kidney diseases from a single Chinese nephrology referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, setting, participants, &amp; measurements<\/jats:title>\n                    <jats:p>Patients who presented with monoclonal gammopathy (monoclonal spike on serum and\/or urine immunofixation tests) and underwent kidney biopsy in the Peking University First Hospital from January 1, 1999 to December 31, 2020 were enrolled in this retrospective study. Patients with malignant hematologic diseases were excluded. Clinical and laboratory data were collected from the electronic medical record system. Comparisons of patients with and without MGRS and with and without amyloidosis were performed. The clinical characteristics associated with MGRS were identified using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 700 patients with monoclonal gammopathy and kidney biopsy were identified. Thirteen patients with repeat kidney biopsies were analyzed separately. For the remaining 687 patients with one kidney biopsy, 261 patients (38%) had MGRS lesions, and the rest (426 patients, 62%) had non-MGRS kidney diseases. Ig-related amyloidosis accounted for the most MGRS cases (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =164, 63%), followed by monoclonal Ig deposition disease (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =23, 9%) and thrombotic microangiopathy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =22, 8%). In the non-MGRS group, membranous nephropathy was the most common diagnosis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =171, 40%). In the multivariable logistic regression model, the presence of abnormal serum free light chain ratio, older age, and greater proteinuria were independently associated with MGRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Monoclonal Ig amyloidosis is the leading cause of MGRS in Chinese patients with monoclonal gammopathy. The presence of abnormal free light chain ratio, older age, and greater proteinuria were associated with MGRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2215\/cjn.12890921","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T10:20:13Z","timestamp":1645698013000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Kidney Histopathologic Spectrum and Clinical Indicators Associated with MGRS"],"prefix":"10.2215","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-7031","authenticated-orcid":false,"given":"Zi-hao","family":"Yong","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People\u2019s Republic of China"},{"name":"Institute of Nephrology, Peking University, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, People\u2019s Republic of China"},{"name":"Peking-Tsinghua Center for Life Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-juan","family":"Yu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People\u2019s Republic of China"},{"name":"Institute of Nephrology, Peking University, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University First Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-de","family":"Zhou","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People\u2019s Republic of China"},{"name":"Institute of Nephrology, Peking University, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People\u2019s Republic of China"},{"name":"Institute of Nephrology, Peking University, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, People\u2019s Republic of China"},{"name":"Laboratory of Electron Microscopy, Pathological Centre, Peking University First Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People\u2019s Republic of China"},{"name":"Institute of Nephrology, Peking University, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, People\u2019s Republic of China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, People\u2019s Republic of China"},{"name":"Peking-Tsinghua Center for Life Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"B1-20241015","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0002-9343(78)90522-3","article-title":"Monoclonal gammopathy of undetermined significance. 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