{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:08:53Z","timestamp":1793394533689,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Acute pancreatitis is a common disorder of the pancreas. It is the most frequent gastrointestinal cause for hospitalization and one of the leading causes of in-hospital deaths. Its severity ranges from mild self-limited disease to severe acute necrotizing pancreatitis characterized by systemic complications and multiorgan failure. Severe acute pancreatitis develops in about 20% of patients with acute pancreatitis and may be associated with multiorgan failure (respiratory, cardiovascular, and kidney). AKI is a frequent complication of severe acute pancreatitis and develops late in the course of the disease, usually after the failure of other organs. It carries a very poor prognosis, particularly if kidney replacement therapy is required, with mortality rates exceeding 75%. The exact pathophysiology of AKI in acute pancreatitis remains unclear but appears to result from initial volume depletion followed by complex vascular and humoral factors. Here, we provide an overview of the epidemiology, pathogenesis, causes, and management of AKI in patients with severe acute pancreatitis.<\/jats:p>","DOI":"10.2215\/cjn.13191118","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T16:45:48Z","timestamp":1558543548000},"page":"1106-1115","source":"Crossref","is-referenced-by-count":158,"title":["AKI Associated with Acute Pancreatitis"],"prefix":"10.2215","volume":"14","author":[{"given":"Tareq I.","family":"Nassar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajeh Y.","family":"Qunibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis--2012: Revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/ajg.2013.218","article-title":"American college of gastroenterology guideline: Management of acute pancreatitis","volume":"108","author":"Tenner","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.pan.2018.10.002","article-title":"Acute pancreatitis: Trends in outcomes and the role of acute kidney injury in mortality- A propensity-matched analysis","volume":"18","author":"Devani","year":"2018","journal-title":"Pancreatology"},{"key":"B4-20230813","first-page":"1079","article-title":"Acute renal failure in patients with acute pancreatitis: Prevalence, risk factors, and outcome","volume":"8","author":"Tran","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3109\/08860229609047686","article-title":"Acute renal failure complicating severe acute pancreatitis","volume":"18","author":"Kes","year":"1996","journal-title":"Ren Fail"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jcrc.2009.07.009","article-title":"Risk factors and outcome of acute renal failure in patients with severe acute pancreatitis","volume":"25","author":"Li","year":"2010","journal-title":"J Crit Care"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/03009734.2010.547636","article-title":"Acute renal failure in severe pancreatitis: A population-based study","volume":"116","author":"Lin","year":"2011","journal-title":"Ups J Med Sci"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/nep.12439","article-title":"Effect of acute kidney injury on mortality and hospital stay in patient with severe acute pancreatitis","volume":"20","author":"Zhou","year":"2015","journal-title":"Nephrology (Carlton)"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.3748\/wjg.v23.i29.5431","article-title":"Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis","volume":"23","author":"Gougol","year":"2017","journal-title":"World J Gastroenterol"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/j.gastro.2007.01.055","article-title":"Acute pancreatitis: Bench to the bedside","volume":"132","author":"Pandol","year":"2007","journal-title":"Gastroenterology"},{"key":"B11-20230813","first-page":"F969","article-title":"Renal failure in dogs with experimental acute pancreatitis: Role of hypovolemia","volume":"251","author":"Levy","year":"1986","journal-title":"Am J Physiol"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF02470871","article-title":"Renal function in experimentally induced acute pancreatitis in dogs: How it is affected by the nephrotoxic substance in pancreatic exudate from ascitic fluid","volume":"21","author":"Satake","year":"1991","journal-title":"Jpn J Surg"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10620-007-9866-5","article-title":"The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: A review of current knowledge","volume":"53","author":"Zhang","year":"2008","journal-title":"Dig Dis Sci"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/00365526909180153","article-title":"Experimental acute pancreatitis in dogs. 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