{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:45:39Z","timestamp":1793357139066,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJASN"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Background and objectives<\/jats:title>\n Preoperative arterial function is associated with arteriovenous fistula (AVF) development. Because arterial pathology may correlate with its function, preexisting arterial intimal hyperplasia may be associated with AVF development.<\/jats:p>\n <\/jats:sec>\n \n Design, setting, participants, & measurements<\/jats:title>\n Vascular specimens obtained from 125 patients (with minimal 2 mm arterial diameter and 2.5 mm venous diameter) undergoing AVF creation were quantified for arterial intimal hyperplasia, arterial medial fibrosis, arterial microcalcification, and venous intimal hyperplasia. A 6-week postoperative ultrasound quantified AVF diameter, blood flow, and stenosis. Clinical AVF maturation was assessed using a predefined protocol. In a prospective cohort study design, we investigated the association of preexisting arterial intimal hyperplasia with the postoperative AVF diameter, blood flow, stenosis, and clinical maturation failure, after controlling for baseline demographics, comorbidities, and preoperative vein diameter. Additional analyses evaluated whether other vascular pathologies interacted with arterial intimal hyperplasia in affecting AVF outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median intimal thickness of the native artery was 22.0\n \u03bc<\/jats:italic>\n m (interquartile range, 14.8\u201337.1\n \u03bc<\/jats:italic>\n m). The median postoperative AVF diameter was 4.8 (interquartile range, 3.7\u20136.8) mm, blood flow was 796 (interquartile range, 413\u20131036) ml\/min, and stenosis was present in 37 out of 98 patients with ultrasound data (38%). AVF nonmaturation occurred in 37 out of 125 patients (30%). Preexisting arterial intimal thickness was not significantly associated with AVF blood flow (\u221212 ml\/min; 95% confidence interval [95% CI], \u221255 to 30 ml\/min), diameter (\u22120.04 mm; 95% CI, \u22120.21 to 0.14 mm), stenosis (odds ratio, 0.93; 95% CI, 0.75 to 1.14), or clinical maturation failure (odds ratio, 1.07; 95% CI, 0.90 to 1.28), all per 10\n \u03bc<\/jats:italic>\n m increase. There was no significant interaction of preexisting arterial intimal thickness and postoperative AVF outcomes with arterial medial fibrosis, arterial microcalcification, or venous intimal hyperplasia.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Preexisting arterial intimal hyperplasia is not associated with the 6-week AVF blood flow, diameter or stenosis, or clinical maturation when the preoperative arterial diameter is \u22652 mm.<\/jats:p>\n <\/jats:sec>","DOI":"10.2215\/cjn.13431217","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T09:55:29Z","timestamp":1535018129000},"page":"1358-1363","source":"Crossref","is-referenced-by-count":13,"title":["Association of Preexisting Arterial Intimal Hyperplasia with Arteriovenous Fistula Outcomes"],"prefix":"10.2215","volume":"13","author":[{"given":"Michael","family":"Allon","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio H.","family":"Litovsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Divisions of Epidemiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha","family":"Le","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred K.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"},{"name":"Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah; and"},{"name":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ting","family":"Shiu","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Internal Medicine, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"B1-20230813","doi-asserted-by":"crossref","first-page":"786","DOI":"10.2215\/CJN.00860207","article-title":"Current management of vascular access.","volume":"2","author":"Allon","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"B2-20230813","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1148\/radiol.2015150385","article-title":"Arteriovenous fistula development in the first 6 weeks after creation.","volume":"279","author":"Robbin","year":"2016","journal-title":"Radiology"},{"key":"B3-20230813","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1046\/j.1523-1755.2003.00210.x","article-title":"Aggressive treatment of early fistula failure.","volume":"64","author":"Beathard","year":"2003","journal-title":"Kidney Int"},{"key":"B4-20230813","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2215\/CJN.02910608","article-title":"Outcomes of brachiocephalic fistulas, transposed brachiobasilic fistulas, and upper arm grafts.","volume":"4","author":"Maya","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"B5-20230813","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.2215\/CJN.01860216","article-title":"New insights into dialysis vascular access: Impact of preexisting arterial and venous pathology on AVF and AVG outcomes.","volume":"11","author":"Vazquez-Padron","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"B6-20230813","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/ajkd.2003.50051","article-title":"Preexisting intimal hyperplasia of radial artery is associated with early failure of radiocephalic arteriovenous fistula in hemodialysis patients.","volume":"41","author":"Kim","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"B7-20230813","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.2215\/CJN.02740313","article-title":"Preoperative venous intimal hyperplasia, postoperative arteriovenous fistula stenosis, and clinical fistula outcomes.","volume":"8","author":"Allon","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"B8-20230813","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1053\/j.ajkd.2016.02.044","article-title":"Pre-existing and postoperative intimal hyperplasia and arteriovenous outcomes.","volume":"68","author":"Tabbara","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"B9-20230813","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1681\/ASN.2016121355","article-title":"Intimal hyperplasia, stenosis, and arteriovenous fistula maturation failure in the hemodialysis fistula maturation study.","volume":"28","author":"Cheung","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B10-20230813","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2215\/CJN.00500116","article-title":"Preoperative vascular medial fibrosis and arteriovenous fistula development.","volume":"11","author":"Shiu","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"B11-20230813","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1148\/radiology.217.1.r00oc2883","article-title":"US vascular mapping before hemodialysis access placement.","volume":"217","author":"Robbin","year":"2000","journal-title":"Radiology"},{"key":"B12-20230813","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1046\/j.1523-1755.2001.00031.x","article-title":"Effect of preoperative sonographic mapping on vascular access outcomes in hemodialysis patients.","volume":"60","author":"Allon","year":"2001","journal-title":"Kidney Int"},{"key":"B13-20230813","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1148\/radiol.2251011367","article-title":"Hemodialysis arteriovenous fistula maturity: US evaluation.","volume":"225","author":"Robbin","year":"2002","journal-title":"Radiology"},{"key":"B14-20230813","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1053\/j.ajkd.2011.04.018","article-title":"Medial fibrosis, vascular calcification, intimal hyperplasia, and arteriovenous fistula maturation.","volume":"58","author":"Allon","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"B15-20230813","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ehj.2003.11.002","article-title":"Sirolimus-eluting stents inhibit neointimal hyperplasia in diabetic patients. 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